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Table 1.

Experimental protocol for different groups

Group 1   TM10 transplanted at 3 weeks of age. No DMBA.  
Group 2   TM10 transplanted at 3 weeks of age and DMBA given at 8 weeks of host age.  
Group 3   TM10 transplanted at 11 weeks of host age into untreated cleared fat pads.  
Group 4   TM10 transplanted at 11 weeks of age into DMBA-treated cleared fat pads.  
Group 5   TM10 transplants that had been treated with DMBA (group 2) transplanted at 11 weeks of age into untreated cleared fat pads.  
Group 6   TM10 transplants that had been treated with DMBA (group 2) transplanted at 11 weeks into DMBA-treated cleared fat pads.  
Group 7   TM10 transplanted at 11 weeks of age (untreated fat pad — group 3), then transplanted as a whole gland into an age-matched untreated host at 12 weeks.  
Group 8   TM10 transplanted at 11 weeks (DMBA-treated fat pad — group 4), then transplanted as a whole gland into an age-matched untreated host at 12 weeks.  
Group 1   TM10 transplanted at 3 weeks of age. No DMBA.  
Group 2   TM10 transplanted at 3 weeks of age and DMBA given at 8 weeks of host age.  
Group 3   TM10 transplanted at 11 weeks of host age into untreated cleared fat pads.  
Group 4   TM10 transplanted at 11 weeks of age into DMBA-treated cleared fat pads.  
Group 5   TM10 transplants that had been treated with DMBA (group 2) transplanted at 11 weeks of age into untreated cleared fat pads.  
Group 6   TM10 transplants that had been treated with DMBA (group 2) transplanted at 11 weeks into DMBA-treated cleared fat pads.  
Group 7   TM10 transplanted at 11 weeks of age (untreated fat pad — group 3), then transplanted as a whole gland into an age-matched untreated host at 12 weeks.  
Group 8   TM10 transplanted at 11 weeks (DMBA-treated fat pad — group 4), then transplanted as a whole gland into an age-matched untreated host at 12 weeks.  

All mice had both inguinal fat pads cleared of epithelial rudiments at 3 weeks of age. Donor transplants were from TM10 hyperplastic mammary outgrowth line. Mice were palpated weekly for tumors for 52 weeks post transplantation.

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