Gene . | Gene ID . | Fold change (FCUL → FCLL) . | Protein information . |
---|---|---|---|
Acid–base and ion regulation | |||
Slc8a3 | SPU_026183 | –1.52 → –1.02 | Na+/Ca2+ exchanger |
Slc41a1 | SPU_001481 | –1.35 → –1.13 | mgtE-like Mg2+ transporter |
Scnn1a | SPU_014519 | –1.43 → –1.07 | Sodium channel |
Aqp | SPU_023979 | –1.40 → –1.09 | Aquaporin, water channel |
Slc12a2 | SPU_004877 | –1.35 → –1.12 | Na+/K+/2Cl– cotransporter |
Slco5a1 | SPU_004407 | –1.29 → –1.06 | Organic anion transporter |
Slc39a3 | SPU_002226 | –1.38 → –1.02 | Zinc transporter |
Slc24a4 | SPU_023689 | –1.37 → +1.03 | Na+/K+/Ca2+ exchanger |
Slco | SPU_007603 | –1.31 → –1.01 | Organic anion transporter |
Slc39a8 | SPU_023011 | –1.33 → +1.02 | Zinc transporter |
Atp13a4 | SPU_005539 | –1.26 → –1.03 | H+/K+-ATPase |
Slc20a2 | SPU_020699 | –1.30 → +1.02 | Na-phosphate transporter, type III |
Atp2a1 | SPU_013051 | –1.20 → –1.06 | Ca2+-ATPase |
Slc5a8 | SPU_012573 | –1.30 → –1.06 | Na+-iodide related transporter |
Slc5a5 | SPU_021781 | –1.36 → +1.02 | Na+-iodide symporter |
Aqp* | SPU_021388 | +1.46 → +1.07 | Aquaporin, water channel and potentially CO2 |
Apoptosis | |||
Caspase 8-like2a | SPU_008540 | –1.27 → –1.04 | Cysteine protease, cell extrinsic pathway of apoptosis |
Caspase 8-like2b | SPU_022177 | –1.29 → 1.00 | Cysteine protease, cell extrinsic pathway of apoptosis |
Caspase 8-like3* | SPU_016039 | –1.28 → –1.18 | Cysteine protease, cell extrinsic pathway of apoptosis |
Caspase 8-like5 | SPU_024371 | –1.36 → +1.05 | Cysteine protease, cell extrinsic pathway of apoptosis |
Caspase 3/7-like | SPU_002280 | –1.33 → –1.05 | Cysteine protease, last caspase in pathway before cell death |
caspase N2a | SPU_009497 | –1.26 → –1.03 | Cysteine protease, N for novel |
caspase N2f | SPU_026743 | –1.32 → –1.01 | Cysteine protease, N for novel |
caspase N3a | SPU_017523 | –1.46 → +1.02 | Cysteine protease, N for novel |
caspase N6a | SPU_006866 | –1.37 → +1.02 | Cysteine protease, N for novel |
caspase N6b | SPU_027596 | –1.27 → –1.03 | Cysteine protease, N for novel |
ICE like-1a | SPU_002921 | –1.75 → +1.26 | Interleukin-converting enzyme, cysteine protease |
ICE like-2 | SPU_021141 | –1.28 → –1.08 | Interleukin-converting enzyme, cysteine protease |
ICE like-3 | SPU_011872 | –1.32 → –1.04 | Interleukin-converting enzyme, cysteine protease |
ICE like-4 | SPU_012722 | –1.34 → –1.08 | Interleukin-converting enzyme, cysteine protease |
Tnfsf-like3 | SPU_015654 | –1.32 → –1.02 | Tumor necrosis factor subfamily like 3, ligand for TNFR with death domain |
Tnfsf-like1 | SPU_009528 | –1.38 → +1.04 | Tumor necrosis factor subfamily like 1, ligand for TNFR lacking death domain |
Tnfrsf1a | SPU_012211 | –1.38 → +1.01 | Tumor necrosis factor receptor (TNFR) superfamily 1, trigger apoptosis upon binding of Ligand (TNF) |
Tnfrsf-like1 | SPU_010230 | –1.28 → –1.06 | TNFR |
Tnfrsf-cl1 | SPU_010180 | –1.36 → 1.00 | TNFR, lacks death domain |
HVEM/Eda2r-like 1 | SPU_024584 | –1.37 → +1.01 | TNFR, lacks death domain |
Troy/Eda2r-like 2 | SPU_020740 | –1.42 → +1.05 | TNFR, lacks death domain |
TRAF3 | SPU_026495 | –1.64 → +1.09 | Tnf receptor-associated factor 3, adaptor without death domain |
TRAF4 | SPU_008332 | –1.38 → –1.02 | Adaptor without death domain |
TRAF6 | SPU_028898 | –1.47 → +1.08 | Adaptor without death domain |
BIRC2b | SPU_014057 | –1.39 → –1.05 | Baculoviral IAP repeat-containing 2, anti-apoptotic |
BOK | SPU_021416 | –1.33 → –1.05 | Bcl2-related ovarian killer, pro-apoptotic |
IAP1 | SPU_014350 | –1.39 → +1.04 | Inhibitor of apoptosis 1, anti-apoptotic |
Mil2 | SPU_001916 | –1.40 → +1.05 | Bcl-2 protein, pro-apoptotic |
Slc22a13 | SPU_017736 | –1.35 → +1.02 | Organic anion transporter, involved in apoptosis |
Slc22a15 | SPU_019637 | –1.24 → –1.05 | Organic anion transporter, involved in apoptosis |
Biomineralization | |||
MSP130* | SPU_013821 | –1.42 → –1.05 | Primary mesenchyme cell (PMC)-specific protein, cell surface |
MSP130-related 6 | SPU_014492 | –1.31 → –1.02 | PMC-specific protein |
Runt-2 | SPU_007852 | –1.34 → –1.09 | Transcription factor, triggers differentiation of skeletogenic cells |
Alx1 | SPU_022817 | –1.37 → –1.05 | PMC-specific protein, required for skeleton formation |
serine rich protein 12 | SPU_015338 | –1.31 → –1.01 | Glycoprotein that binds calcium |
SPARC-like | SPU_012548 | –1.46→ +1.10 | Secreted protein acidic and rich in cysteine, binds Ca2+ |
Casr | SPU_0017585 | –1.26→ –1.04 | Calcium receptor |
CA-4 likeB | SPU_022346 | –1.38 → +1.04 | Carbonic anhydrase, catalyzes reversible hydration of CO2 to bicarbonate and protons |
CA-10 like | SPU_0004135 | –1.31→ 1.00 | Carbonic anhydrase |
CA-8 likeB | SPU_026483 | –1.23→ –1.06 | Carbonic anhydrase |
CA-12 likeB | SPU_025722 | –1.21→ –1.06 | Carbonic anhydrase |
CA-7 likeA | SPU_012518 | +1.55→ +1.03 | Carbonic anhydrase, extracellular |
Cell cycle | |||
Cdc23/Apc8 | SPU_012696 | –1.72 → –1.24 | Cell division cycle 23, ubiquitin-proteolysis pathway |
Slc29a4 | SPU_008397 | –1.47 → –1.10 | Nucleoside transporter |
Slc28a2 | SPU_025779 | –1.38 → –1.01 | Na+-coupled nucleoside transporter |
Apc11 | SPU_021695 | –1.28 → –1.07 | Anaphase promoting complex 11, ubiquitin-proteolysis pathway |
Myt1 | SPU_008280 | –1.32 → –1.04 | Tyrosine kinase, inhibits cylin dependent kinase 1 |
PFAIRE | SPU_003654 | –1.46 → +1.07 | Cyclin dependent kinase |
Neka | SPU_017790 | –1.41 → +1.07 | NIMA related kinase, mitotic kinase |
SMC1 | SPU_021629 | +1.46 → +1.05 | Structural maintenance of chromosome 1, condensin/cohesin complexes |
SMC4* | SPU_013617 | +1.31 → 1.00 | Structural maintenance of chromosome 4, condensin/cohesin complexes |
Cellular stress defensome | |||
Protein homeostasis | |||
Hsp100B | SPU_006012 | –1.44 → +1.04 | 100kDa heat shock protein, molecular chaperone |
Hsp701B | SPU_005808 | –1.36 → +1.01 | 70kDa heat shock protein, molecular chaperone |
Hsp701F | SPU_013289 | –1.26 → –1.04 | 70kDa heat shock protein, molecular chaperone |
Hsp703A | SPU_014864 | –1.33 → 1.00 | 70kDa heat shock protein, molecular chaperone |
Hsp70–like | SPU_021458 | –1.32 → +1.03 | 70kDa heat shock protein, molecular chaperone |
Hsp20.1 | SPU_001357 | –1.19 → –1.12 | 20kDa heat shock protein, molecular chaperone |
Hsp20.2 | SPU_020294 | –1.32 → 1.00 | 20kDa heat shock protein, molecular chaperone |
UBXD1 | SPU_012427 | –1.33 → –1.02 | UBX domain containing 1, Ub-proteasome pathway |
ubiquitin | SPU_015276 | +1.38 → +1.15 | Ubiquitin-proteasome pathway, signaling |
Hsp40A* | SPU_016562 | +1.39 → +1.08 | 40kDa heat shock protein, co-chaperone of Hsp70 |
Antioxidant defense | |||
Maf | SPU_025888 | –1.36 → –1.07 | Transcription factor, oxidative stress-responsive |
MGST-2 | SPU_008286 | –1.48 → +1.08 | Glutathione S-transferase, microsomal |
GST-12 | SPU_023664 | –1.32 → 1.00 | Glutathione S-transferase, cytosolic |
Gpx1 | SPU_004397 | –1.42 → +1.05 | Glutathione peroxidase 7 |
Toxicant, metal and xenobiotic defense | |||
Akr1a-like | SPU_027986 | –1.31 → –1.10 | Aldo-keto reductase |
Akr1b-like2 | SPU_016996 | –1.33 → –1.10 | Aldo-keto reductase |
Akr1b-like3 | SPU_018466 | –1.54 → +1.14 | Aldo-keto reductase |
Cyp2-like9* | SPU_003606 | –1.36 → –1.07 | Cytochrome P450 monooxygenase, iron homeostasis |
Cyp3-like8 | SPU_016056 | –1.38 → –1.01 | Cytochrome P450 monooxygenase |
Cyp4-like5 | SPU_007558 | –1.37 → +1.02 | Cytochrome P450 monooxygenase |
Cyp2-like14 | SPU_006574 | –1.21 → –1.08 | Cytochrome P450 monooxygenase |
Fmo5 | SPU_022596 | –1.26 → –1.08 | Flavin-containing monooxygenase 5 |
Fmo3 | SPU_022597 | –1.35 → +1.02 | Flavin-containing monooxygenase 3 |
ABCC9i | SPU_018527 | –1.39 → –1.02 | ATP-binding cassette superfamily, efflux transporter |
ABCG2 | SPU_024785 | –1.37 → 1.00 | ATP-binding cassette superfamily, efflux transporter |
Aldh3a1 | SPU_009853 | –1.32 → 1.00 | Aldehyde dehydrogenase |
Nat-like | SPU_012976 | –1.20 → –1.09 | N-acyltransferase-like |
NR1H6a | SPU_017404 | –1.31 → –1.09 | Nuclear receptor subfamily 1 H member 6a |
Ark1b-like4 | SPU_028344 | +1.46 → +1.05 | Aldo-keto reductase |
Fth1 | SPU_004876 | +1.52 → +1.07 | Heavy chain of ferritin, iron storage |
Fmo2 | SPU_014947 | +1.21 → +1.09 | Flavin-containing monooxygenase 2 |
Adrenergic stress response | |||
nAChR α7 | SPU_013095 | –1.37 → –1.01 | Acetylcholine receptor, nicotinic |
nAChR α9 | SPU_005670 | –1.36 → +1.00 | Acetylcholine receptor, nicotinic |
nAChR α4 | SPU_019711 | –1.56 → +1.17 | Acetylcholine receptor, nicotinic |
mAChR M5 | SPU_016177 | –1.45 → +1.07 | Acetylcholine receptor, muscarinic |
mAChR M4 | SPU_019228 | –1.30 → –1.02 | Acetylcholine receptor, muscarinic |
Slc22a3 | SPU_006524 | –1.39 → –1.04 | Monoamine transporter, extraneuronal |
Slc6a2 | SPU_022506 | –1.35 → +1.05 | Sodium-dependent noradrenaline transporter |
calcineurin | SPU_018404 | –1.25 → –1.08 | Activates transcription of interleukin 2 |
SNAP-25 | SPU_006859 | –1.27 → –1.02 | Synaptosome-associated protein |
Development | |||
FoxB | SPU_004551 | –1.20 → –1.10 | Forkhead box B, transcription factor |
Trh | SPU_014249 | –1.29 → 1.00 | Neuronal PAS domain protein |
early-histone-H2a | SPU_002577 | +1.62 → +1.03 | Involved in nucleosome assembly |
FoxQ2 | SPU_019002 | +1.43 → +1.30 | Forkhead box Q2, involved in axis specification |
Not | SPU_002129 | +1.42 → +1.03 | Transcription factor involved in differentiation |
PKS-like* | SPU_002895 | +1.41 → +1.05 | Polyketide synthase, pigment synthesis |
Eve | SPU_012253 | +1.39 → +1.08 | Even-skipped, body morphogenesis |
Hes | SPU_021608 | +1.28 → +1.14 | Hairy/enhancer of split, role in skeletogenic GRN |
Otx | SPU_010424 | +1.40 → –1.04 | Orthodenticle homeobox, role in endomesoderm GRN |
Kinome | |||
FAK | SPU_019686 | –1.30 → –1.11 | Focal adhesion kinase, cytoskeletal kinase |
KIS | SPU_027616 | –1.32 → –1.09 | Kinase interacting stathmin, cytoskeletal kinase |
MLCKb | SPU_000442 | –1.37 → –1.04 | Myosin light chain kinase, cytoskeletal kinase |
projectin | SPU_013917 | –1.33 → –1.06 | Cytoskeletal kinase |
MAPKAPK5a | SPU_013910 | –1.24 → –1.14 | Mitogen-activated protein kinase signaling |
JAK2 | SPU_020082 | –1.47 → +1.06 | Janus kinase 2, receptor signaling |
JAK1 | SPU_022495 | –1.34 → –1.02 | Janus kinase 1, receptor signaling |
titin | SPU_005613 | –1.23 → –1.11 | Cytoskeletal kinase |
RIPK1-4A | SPU_005215 | –1.27 → –1.06 | Receptor-interacting protein kinase, death kinase |
LIMK | SPU_022207 | –1.56 → +1.17 | LIM domain kinase, cytoskeletal kinase |
ULK3 | SPU_017980 | –1.26 → –1.05 | Unc-51-like kinase 3, cytoskeletal kinase |
Metabolism | |||
Energy metabolism | |||
Slc25a5* | SPU_004813 | –1.92 → –1.17 | ADP, ATP carrier protein 2, energy transfer |
Slc25a21 | SPU_006682 | –1.41 → +1.06 | Mitochondrial oxodicarboxylate carrier, energy transfer |
Atp5b | SPU_005296 | +1.51 → –1.01 | ATP synthase, H+ transporting, F1 complex |
Carbohydrate metabolism | |||
glycosidase | SPU_010831 | –1.38 → –1.08 | Glycosidase, degrades complex carbohydrates |
β-d-xylosidase | SPU_021638 | –1.34 → 1.00 | β-d-xylosidase, glycosidase |
Ldh-d | SPU_026206 | –1.24 → –1.08 | Lactate dehydrogenase d, anaerobic glycolysis |
Mdh-1 | SPU_023277 | –1.33 → +1.05 | Malate dehydrogenase 1, citric acid cycle |
Pgm | SPU_024573 | –1.29 → –1.01 | Phosphoglycerate mutase, glycolysis |
Pgm2-like1 | SPU_028876 | –1.51 → +1.13 | Phosphoglycerate mutase 2-like 1, glycolysis |
Slc5a9 | SPU_021455 | –1.31 → –1.11 | Na+/glucose cotransporter |
Slc5a2 | SPU_003667 | –1.35 → +1.03 | Na+/glucose transporter, low affinity |
Slc5a12 | SPU_018791 | –1.39 → +1.07 | Na+/glucose cotransporter |
Slc2a5 | SPU_027868 | –1.31 → 1.00 | Glucose/fructose transporter |
Slc2a13 | SPU_017752 | –1.30 → +1.01 | H+ myo-inositol symporter, glucose transport |
Slc37a3 | SPU_011768 | –1.37 → +1.02 | Glycerol-3-phosphate transporter |
Slc16a12 | SPU_004404 | –1.33 → –1.08 | Monocarboxylate transporter |
Slc16a6 | SPU_016408 | –1.77 → +1.33 | Monocarboxylate transporter |
Slc16a4 | SPU_009336 | –1.53 → +1.17 | Monocarboxylate transporter |
Slc35a4 | SPU_019603 | –1.30 → 1.00 | UDP-galactose transporter |
Amino acid metabolism | |||
amidase-like | SPU_005666 | –1.32 → –1.03 | Amidase, hydrolase acting on C–N bonds |
amidase-like | SPU_002810 | –1.59 → +1.18 | Amidase, hydrolase acting on C–N bonds |
amidase-like | SPU_017354 | –1.29 → –1.03 | Amidase, hydrolase acting on C–N bonds |
aulfite reductase | SPU_019708 | –1.55 → +1.14 | Sulfite reductase, selenoamino acid metabolism |
Slc7a9 | SPU_021169 | –1.45 → –1.18 | Cationic amino acid transporter |
Slc7a1 | SPU_028697 | –1.24 → –1.12 | Cationic amino acid transporter |
Slc7a6 | SPU_004504 | –1.25 → –1.09 | Cationic amino acid transporter |
Slc7a5 | SPU_016082 | –1.47 → +1.08 | Cationic amino acid transporter, L-type |
Slc43a3 | SPU_002402 | –1.33 → –1.06 | FOAP-13, Na+-independent amino acid transporter |
Slc36a1 | SPU_022045 | –1.43 → +1.06 | Proton-coupled amino acid transporter |
Slc15a2 | SPU_012690 | –1.25 → –1.08 | H+/peptide transporter |
Slc15a4 | SPU_028146 | –1.51 → +1.09 | Peptide/histidine transporter |
Slc7a11 | SPU_007905 | –1.41 → +1.05 | Cystine/glutamate transporter |
Slc32a1 | SPU_025947 | –1.35 → –1.01 | GABA and glycine transporter |
Dur3 | SPU_011497 | –1.49 → +1.08 | Urea transporter |
Slc3a1 | SPU_013735 | +1.30 → +1.04 | Dibasic and neutral amino acid transport |
Lipid metabolism | |||
Acss1 | SPU_018270 | –1.38 → +1.03 | Acyl-CoA synthetase, lipid biosynthesis |
Slc5a7 | SPU_020026 | –1.36 → 1.00 | Choline transporter, high affinity |
Slc10a2 | SPU_023059 | –1.29 → –1.04 | Na+ bile salt transporter |
Slc10a1 | SPU_003103 | –1.38 → +1.06 | Na+ bile salt transporter |
Vitamin metabolism | |||
Slc5a6 | SPU_023702 | –1.36 → –1.01 | Na+-dependent vitamin transporter |
Nucleotide metabolism | |||
PRPS | SPU_009841 | –1.20 → –1.08 | Phosphoribosyl pyrophosphate synthetase |
Protein synthesis – translational control | |||
elF3j* | SPU_013398 | –1.48 → –1.32 | Translation factor – initiation |
elF2Bβ* | SPU_004173 | –1.40 → –1.20 | Translation factor – initiation |
elF5Bϵ | SPU_015443 | –1.28 → –1.04 | Translation factor – initiation |
elF4E-BP | SPU_005957 | –1.63 → +1.17 | Translation factor – initiation |
elF5B | SPU_001393 | –1.67 → 1.06 | Translation factor – initiation |
elF2Bα | SPU_024859 | –1.65 → 1.07 | Translation factor – initiation |
UPF3 | SPU_000502 | –1.32 → –1.07 | Up-frameshift protein, translation factor – termination |
Gene . | Gene ID . | Fold change (FCUL → FCLL) . | Protein information . |
---|---|---|---|
Acid–base and ion regulation | |||
Slc8a3 | SPU_026183 | –1.52 → –1.02 | Na+/Ca2+ exchanger |
Slc41a1 | SPU_001481 | –1.35 → –1.13 | mgtE-like Mg2+ transporter |
Scnn1a | SPU_014519 | –1.43 → –1.07 | Sodium channel |
Aqp | SPU_023979 | –1.40 → –1.09 | Aquaporin, water channel |
Slc12a2 | SPU_004877 | –1.35 → –1.12 | Na+/K+/2Cl– cotransporter |
Slco5a1 | SPU_004407 | –1.29 → –1.06 | Organic anion transporter |
Slc39a3 | SPU_002226 | –1.38 → –1.02 | Zinc transporter |
Slc24a4 | SPU_023689 | –1.37 → +1.03 | Na+/K+/Ca2+ exchanger |
Slco | SPU_007603 | –1.31 → –1.01 | Organic anion transporter |
Slc39a8 | SPU_023011 | –1.33 → +1.02 | Zinc transporter |
Atp13a4 | SPU_005539 | –1.26 → –1.03 | H+/K+-ATPase |
Slc20a2 | SPU_020699 | –1.30 → +1.02 | Na-phosphate transporter, type III |
Atp2a1 | SPU_013051 | –1.20 → –1.06 | Ca2+-ATPase |
Slc5a8 | SPU_012573 | –1.30 → –1.06 | Na+-iodide related transporter |
Slc5a5 | SPU_021781 | –1.36 → +1.02 | Na+-iodide symporter |
Aqp* | SPU_021388 | +1.46 → +1.07 | Aquaporin, water channel and potentially CO2 |
Apoptosis | |||
Caspase 8-like2a | SPU_008540 | –1.27 → –1.04 | Cysteine protease, cell extrinsic pathway of apoptosis |
Caspase 8-like2b | SPU_022177 | –1.29 → 1.00 | Cysteine protease, cell extrinsic pathway of apoptosis |
Caspase 8-like3* | SPU_016039 | –1.28 → –1.18 | Cysteine protease, cell extrinsic pathway of apoptosis |
Caspase 8-like5 | SPU_024371 | –1.36 → +1.05 | Cysteine protease, cell extrinsic pathway of apoptosis |
Caspase 3/7-like | SPU_002280 | –1.33 → –1.05 | Cysteine protease, last caspase in pathway before cell death |
caspase N2a | SPU_009497 | –1.26 → –1.03 | Cysteine protease, N for novel |
caspase N2f | SPU_026743 | –1.32 → –1.01 | Cysteine protease, N for novel |
caspase N3a | SPU_017523 | –1.46 → +1.02 | Cysteine protease, N for novel |
caspase N6a | SPU_006866 | –1.37 → +1.02 | Cysteine protease, N for novel |
caspase N6b | SPU_027596 | –1.27 → –1.03 | Cysteine protease, N for novel |
ICE like-1a | SPU_002921 | –1.75 → +1.26 | Interleukin-converting enzyme, cysteine protease |
ICE like-2 | SPU_021141 | –1.28 → –1.08 | Interleukin-converting enzyme, cysteine protease |
ICE like-3 | SPU_011872 | –1.32 → –1.04 | Interleukin-converting enzyme, cysteine protease |
ICE like-4 | SPU_012722 | –1.34 → –1.08 | Interleukin-converting enzyme, cysteine protease |
Tnfsf-like3 | SPU_015654 | –1.32 → –1.02 | Tumor necrosis factor subfamily like 3, ligand for TNFR with death domain |
Tnfsf-like1 | SPU_009528 | –1.38 → +1.04 | Tumor necrosis factor subfamily like 1, ligand for TNFR lacking death domain |
Tnfrsf1a | SPU_012211 | –1.38 → +1.01 | Tumor necrosis factor receptor (TNFR) superfamily 1, trigger apoptosis upon binding of Ligand (TNF) |
Tnfrsf-like1 | SPU_010230 | –1.28 → –1.06 | TNFR |
Tnfrsf-cl1 | SPU_010180 | –1.36 → 1.00 | TNFR, lacks death domain |
HVEM/Eda2r-like 1 | SPU_024584 | –1.37 → +1.01 | TNFR, lacks death domain |
Troy/Eda2r-like 2 | SPU_020740 | –1.42 → +1.05 | TNFR, lacks death domain |
TRAF3 | SPU_026495 | –1.64 → +1.09 | Tnf receptor-associated factor 3, adaptor without death domain |
TRAF4 | SPU_008332 | –1.38 → –1.02 | Adaptor without death domain |
TRAF6 | SPU_028898 | –1.47 → +1.08 | Adaptor without death domain |
BIRC2b | SPU_014057 | –1.39 → –1.05 | Baculoviral IAP repeat-containing 2, anti-apoptotic |
BOK | SPU_021416 | –1.33 → –1.05 | Bcl2-related ovarian killer, pro-apoptotic |
IAP1 | SPU_014350 | –1.39 → +1.04 | Inhibitor of apoptosis 1, anti-apoptotic |
Mil2 | SPU_001916 | –1.40 → +1.05 | Bcl-2 protein, pro-apoptotic |
Slc22a13 | SPU_017736 | –1.35 → +1.02 | Organic anion transporter, involved in apoptosis |
Slc22a15 | SPU_019637 | –1.24 → –1.05 | Organic anion transporter, involved in apoptosis |
Biomineralization | |||
MSP130* | SPU_013821 | –1.42 → –1.05 | Primary mesenchyme cell (PMC)-specific protein, cell surface |
MSP130-related 6 | SPU_014492 | –1.31 → –1.02 | PMC-specific protein |
Runt-2 | SPU_007852 | –1.34 → –1.09 | Transcription factor, triggers differentiation of skeletogenic cells |
Alx1 | SPU_022817 | –1.37 → –1.05 | PMC-specific protein, required for skeleton formation |
serine rich protein 12 | SPU_015338 | –1.31 → –1.01 | Glycoprotein that binds calcium |
SPARC-like | SPU_012548 | –1.46→ +1.10 | Secreted protein acidic and rich in cysteine, binds Ca2+ |
Casr | SPU_0017585 | –1.26→ –1.04 | Calcium receptor |
CA-4 likeB | SPU_022346 | –1.38 → +1.04 | Carbonic anhydrase, catalyzes reversible hydration of CO2 to bicarbonate and protons |
CA-10 like | SPU_0004135 | –1.31→ 1.00 | Carbonic anhydrase |
CA-8 likeB | SPU_026483 | –1.23→ –1.06 | Carbonic anhydrase |
CA-12 likeB | SPU_025722 | –1.21→ –1.06 | Carbonic anhydrase |
CA-7 likeA | SPU_012518 | +1.55→ +1.03 | Carbonic anhydrase, extracellular |
Cell cycle | |||
Cdc23/Apc8 | SPU_012696 | –1.72 → –1.24 | Cell division cycle 23, ubiquitin-proteolysis pathway |
Slc29a4 | SPU_008397 | –1.47 → –1.10 | Nucleoside transporter |
Slc28a2 | SPU_025779 | –1.38 → –1.01 | Na+-coupled nucleoside transporter |
Apc11 | SPU_021695 | –1.28 → –1.07 | Anaphase promoting complex 11, ubiquitin-proteolysis pathway |
Myt1 | SPU_008280 | –1.32 → –1.04 | Tyrosine kinase, inhibits cylin dependent kinase 1 |
PFAIRE | SPU_003654 | –1.46 → +1.07 | Cyclin dependent kinase |
Neka | SPU_017790 | –1.41 → +1.07 | NIMA related kinase, mitotic kinase |
SMC1 | SPU_021629 | +1.46 → +1.05 | Structural maintenance of chromosome 1, condensin/cohesin complexes |
SMC4* | SPU_013617 | +1.31 → 1.00 | Structural maintenance of chromosome 4, condensin/cohesin complexes |
Cellular stress defensome | |||
Protein homeostasis | |||
Hsp100B | SPU_006012 | –1.44 → +1.04 | 100kDa heat shock protein, molecular chaperone |
Hsp701B | SPU_005808 | –1.36 → +1.01 | 70kDa heat shock protein, molecular chaperone |
Hsp701F | SPU_013289 | –1.26 → –1.04 | 70kDa heat shock protein, molecular chaperone |
Hsp703A | SPU_014864 | –1.33 → 1.00 | 70kDa heat shock protein, molecular chaperone |
Hsp70–like | SPU_021458 | –1.32 → +1.03 | 70kDa heat shock protein, molecular chaperone |
Hsp20.1 | SPU_001357 | –1.19 → –1.12 | 20kDa heat shock protein, molecular chaperone |
Hsp20.2 | SPU_020294 | –1.32 → 1.00 | 20kDa heat shock protein, molecular chaperone |
UBXD1 | SPU_012427 | –1.33 → –1.02 | UBX domain containing 1, Ub-proteasome pathway |
ubiquitin | SPU_015276 | +1.38 → +1.15 | Ubiquitin-proteasome pathway, signaling |
Hsp40A* | SPU_016562 | +1.39 → +1.08 | 40kDa heat shock protein, co-chaperone of Hsp70 |
Antioxidant defense | |||
Maf | SPU_025888 | –1.36 → –1.07 | Transcription factor, oxidative stress-responsive |
MGST-2 | SPU_008286 | –1.48 → +1.08 | Glutathione S-transferase, microsomal |
GST-12 | SPU_023664 | –1.32 → 1.00 | Glutathione S-transferase, cytosolic |
Gpx1 | SPU_004397 | –1.42 → +1.05 | Glutathione peroxidase 7 |
Toxicant, metal and xenobiotic defense | |||
Akr1a-like | SPU_027986 | –1.31 → –1.10 | Aldo-keto reductase |
Akr1b-like2 | SPU_016996 | –1.33 → –1.10 | Aldo-keto reductase |
Akr1b-like3 | SPU_018466 | –1.54 → +1.14 | Aldo-keto reductase |
Cyp2-like9* | SPU_003606 | –1.36 → –1.07 | Cytochrome P450 monooxygenase, iron homeostasis |
Cyp3-like8 | SPU_016056 | –1.38 → –1.01 | Cytochrome P450 monooxygenase |
Cyp4-like5 | SPU_007558 | –1.37 → +1.02 | Cytochrome P450 monooxygenase |
Cyp2-like14 | SPU_006574 | –1.21 → –1.08 | Cytochrome P450 monooxygenase |
Fmo5 | SPU_022596 | –1.26 → –1.08 | Flavin-containing monooxygenase 5 |
Fmo3 | SPU_022597 | –1.35 → +1.02 | Flavin-containing monooxygenase 3 |
ABCC9i | SPU_018527 | –1.39 → –1.02 | ATP-binding cassette superfamily, efflux transporter |
ABCG2 | SPU_024785 | –1.37 → 1.00 | ATP-binding cassette superfamily, efflux transporter |
Aldh3a1 | SPU_009853 | –1.32 → 1.00 | Aldehyde dehydrogenase |
Nat-like | SPU_012976 | –1.20 → –1.09 | N-acyltransferase-like |
NR1H6a | SPU_017404 | –1.31 → –1.09 | Nuclear receptor subfamily 1 H member 6a |
Ark1b-like4 | SPU_028344 | +1.46 → +1.05 | Aldo-keto reductase |
Fth1 | SPU_004876 | +1.52 → +1.07 | Heavy chain of ferritin, iron storage |
Fmo2 | SPU_014947 | +1.21 → +1.09 | Flavin-containing monooxygenase 2 |
Adrenergic stress response | |||
nAChR α7 | SPU_013095 | –1.37 → –1.01 | Acetylcholine receptor, nicotinic |
nAChR α9 | SPU_005670 | –1.36 → +1.00 | Acetylcholine receptor, nicotinic |
nAChR α4 | SPU_019711 | –1.56 → +1.17 | Acetylcholine receptor, nicotinic |
mAChR M5 | SPU_016177 | –1.45 → +1.07 | Acetylcholine receptor, muscarinic |
mAChR M4 | SPU_019228 | –1.30 → –1.02 | Acetylcholine receptor, muscarinic |
Slc22a3 | SPU_006524 | –1.39 → –1.04 | Monoamine transporter, extraneuronal |
Slc6a2 | SPU_022506 | –1.35 → +1.05 | Sodium-dependent noradrenaline transporter |
calcineurin | SPU_018404 | –1.25 → –1.08 | Activates transcription of interleukin 2 |
SNAP-25 | SPU_006859 | –1.27 → –1.02 | Synaptosome-associated protein |
Development | |||
FoxB | SPU_004551 | –1.20 → –1.10 | Forkhead box B, transcription factor |
Trh | SPU_014249 | –1.29 → 1.00 | Neuronal PAS domain protein |
early-histone-H2a | SPU_002577 | +1.62 → +1.03 | Involved in nucleosome assembly |
FoxQ2 | SPU_019002 | +1.43 → +1.30 | Forkhead box Q2, involved in axis specification |
Not | SPU_002129 | +1.42 → +1.03 | Transcription factor involved in differentiation |
PKS-like* | SPU_002895 | +1.41 → +1.05 | Polyketide synthase, pigment synthesis |
Eve | SPU_012253 | +1.39 → +1.08 | Even-skipped, body morphogenesis |
Hes | SPU_021608 | +1.28 → +1.14 | Hairy/enhancer of split, role in skeletogenic GRN |
Otx | SPU_010424 | +1.40 → –1.04 | Orthodenticle homeobox, role in endomesoderm GRN |
Kinome | |||
FAK | SPU_019686 | –1.30 → –1.11 | Focal adhesion kinase, cytoskeletal kinase |
KIS | SPU_027616 | –1.32 → –1.09 | Kinase interacting stathmin, cytoskeletal kinase |
MLCKb | SPU_000442 | –1.37 → –1.04 | Myosin light chain kinase, cytoskeletal kinase |
projectin | SPU_013917 | –1.33 → –1.06 | Cytoskeletal kinase |
MAPKAPK5a | SPU_013910 | –1.24 → –1.14 | Mitogen-activated protein kinase signaling |
JAK2 | SPU_020082 | –1.47 → +1.06 | Janus kinase 2, receptor signaling |
JAK1 | SPU_022495 | –1.34 → –1.02 | Janus kinase 1, receptor signaling |
titin | SPU_005613 | –1.23 → –1.11 | Cytoskeletal kinase |
RIPK1-4A | SPU_005215 | –1.27 → –1.06 | Receptor-interacting protein kinase, death kinase |
LIMK | SPU_022207 | –1.56 → +1.17 | LIM domain kinase, cytoskeletal kinase |
ULK3 | SPU_017980 | –1.26 → –1.05 | Unc-51-like kinase 3, cytoskeletal kinase |
Metabolism | |||
Energy metabolism | |||
Slc25a5* | SPU_004813 | –1.92 → –1.17 | ADP, ATP carrier protein 2, energy transfer |
Slc25a21 | SPU_006682 | –1.41 → +1.06 | Mitochondrial oxodicarboxylate carrier, energy transfer |
Atp5b | SPU_005296 | +1.51 → –1.01 | ATP synthase, H+ transporting, F1 complex |
Carbohydrate metabolism | |||
glycosidase | SPU_010831 | –1.38 → –1.08 | Glycosidase, degrades complex carbohydrates |
β-d-xylosidase | SPU_021638 | –1.34 → 1.00 | β-d-xylosidase, glycosidase |
Ldh-d | SPU_026206 | –1.24 → –1.08 | Lactate dehydrogenase d, anaerobic glycolysis |
Mdh-1 | SPU_023277 | –1.33 → +1.05 | Malate dehydrogenase 1, citric acid cycle |
Pgm | SPU_024573 | –1.29 → –1.01 | Phosphoglycerate mutase, glycolysis |
Pgm2-like1 | SPU_028876 | –1.51 → +1.13 | Phosphoglycerate mutase 2-like 1, glycolysis |
Slc5a9 | SPU_021455 | –1.31 → –1.11 | Na+/glucose cotransporter |
Slc5a2 | SPU_003667 | –1.35 → +1.03 | Na+/glucose transporter, low affinity |
Slc5a12 | SPU_018791 | –1.39 → +1.07 | Na+/glucose cotransporter |
Slc2a5 | SPU_027868 | –1.31 → 1.00 | Glucose/fructose transporter |
Slc2a13 | SPU_017752 | –1.30 → +1.01 | H+ myo-inositol symporter, glucose transport |
Slc37a3 | SPU_011768 | –1.37 → +1.02 | Glycerol-3-phosphate transporter |
Slc16a12 | SPU_004404 | –1.33 → –1.08 | Monocarboxylate transporter |
Slc16a6 | SPU_016408 | –1.77 → +1.33 | Monocarboxylate transporter |
Slc16a4 | SPU_009336 | –1.53 → +1.17 | Monocarboxylate transporter |
Slc35a4 | SPU_019603 | –1.30 → 1.00 | UDP-galactose transporter |
Amino acid metabolism | |||
amidase-like | SPU_005666 | –1.32 → –1.03 | Amidase, hydrolase acting on C–N bonds |
amidase-like | SPU_002810 | –1.59 → +1.18 | Amidase, hydrolase acting on C–N bonds |
amidase-like | SPU_017354 | –1.29 → –1.03 | Amidase, hydrolase acting on C–N bonds |
aulfite reductase | SPU_019708 | –1.55 → +1.14 | Sulfite reductase, selenoamino acid metabolism |
Slc7a9 | SPU_021169 | –1.45 → –1.18 | Cationic amino acid transporter |
Slc7a1 | SPU_028697 | –1.24 → –1.12 | Cationic amino acid transporter |
Slc7a6 | SPU_004504 | –1.25 → –1.09 | Cationic amino acid transporter |
Slc7a5 | SPU_016082 | –1.47 → +1.08 | Cationic amino acid transporter, L-type |
Slc43a3 | SPU_002402 | –1.33 → –1.06 | FOAP-13, Na+-independent amino acid transporter |
Slc36a1 | SPU_022045 | –1.43 → +1.06 | Proton-coupled amino acid transporter |
Slc15a2 | SPU_012690 | –1.25 → –1.08 | H+/peptide transporter |
Slc15a4 | SPU_028146 | –1.51 → +1.09 | Peptide/histidine transporter |
Slc7a11 | SPU_007905 | –1.41 → +1.05 | Cystine/glutamate transporter |
Slc32a1 | SPU_025947 | –1.35 → –1.01 | GABA and glycine transporter |
Dur3 | SPU_011497 | –1.49 → +1.08 | Urea transporter |
Slc3a1 | SPU_013735 | +1.30 → +1.04 | Dibasic and neutral amino acid transport |
Lipid metabolism | |||
Acss1 | SPU_018270 | –1.38 → +1.03 | Acyl-CoA synthetase, lipid biosynthesis |
Slc5a7 | SPU_020026 | –1.36 → 1.00 | Choline transporter, high affinity |
Slc10a2 | SPU_023059 | –1.29 → –1.04 | Na+ bile salt transporter |
Slc10a1 | SPU_003103 | –1.38 → +1.06 | Na+ bile salt transporter |
Vitamin metabolism | |||
Slc5a6 | SPU_023702 | –1.36 → –1.01 | Na+-dependent vitamin transporter |
Nucleotide metabolism | |||
PRPS | SPU_009841 | –1.20 → –1.08 | Phosphoribosyl pyrophosphate synthetase |
Protein synthesis – translational control | |||
elF3j* | SPU_013398 | –1.48 → –1.32 | Translation factor – initiation |
elF2Bβ* | SPU_004173 | –1.40 → –1.20 | Translation factor – initiation |
elF5Bϵ | SPU_015443 | –1.28 → –1.04 | Translation factor – initiation |
elF4E-BP | SPU_005957 | –1.63 → +1.17 | Translation factor – initiation |
elF5B | SPU_001393 | –1.67 → 1.06 | Translation factor – initiation |
elF2Bα | SPU_024859 | –1.65 → 1.07 | Translation factor – initiation |
UPF3 | SPU_000502 | –1.32 → –1.07 | Up-frameshift protein, translation factor – termination |
Data are presented as the upper (FCUL) and lower (FCLL) limits of fold change
Genes that were also within the group of mRNA transcripts that changed significantly in response to Moderate CO2 conditions