Phenotypic classification of Cited2-null embryos
| . | Group 1 (n=9) . | Group 2 (n=4) . | Group 3 (n=8) . | Group 4 (n=3) . |
|---|---|---|---|---|
| Right pulmonary isomerism | 9 | |||
| Right atrial isomerism | 9 | |||
| ASD | 9, common atrium | 4, foramen primum | ||
| AV junction | 9, common AV canal | 4, common AV canal, DILV | ||
| VSD | 9, membranous, muscular | 4, membranous, muscular | 6, membranous, muscular | 3, membranous, muscular |
| Outflow tract | 9, DORV, TGA | 4, DORV, PTA | 8, DORV, TGA, OA | |
| Pharyngeal arch arteries | 9, RERSA, IAA type B | 4, RERSA, IAA type B |
| . | Group 1 (n=9) . | Group 2 (n=4) . | Group 3 (n=8) . | Group 4 (n=3) . |
|---|---|---|---|---|
| Right pulmonary isomerism | 9 | |||
| Right atrial isomerism | 9 | |||
| ASD | 9, common atrium | 4, foramen primum | ||
| AV junction | 9, common AV canal | 4, common AV canal, DILV | ||
| VSD | 9, membranous, muscular | 4, membranous, muscular | 6, membranous, muscular | 3, membranous, muscular |
| Outflow tract | 9, DORV, TGA | 4, DORV, PTA | 8, DORV, TGA, OA | |
| Pharyngeal arch arteries | 9, RERSA, IAA type B | 4, RERSA, IAA type B |
A total of 28 embryos were analysed by EFIC and scored for phenotype of the cardiovascular system and lungs. Four embryos showed normal cardiovascular and pulmonary structure and the remaining 24 were classified into four groups by severity of phenotype. ASD, atrial septal defect; AV, atrioventricular; VSD,ventricular septal defects; DILV, double inlet left ventricle; DORV, double outlet left ventricle; TGA, transposition of the great arteries; PTA,persistent truncus arteriousus; OA, overriding aorta; RERSA, retro-esophogeal right subclavian artery; IAA, interrupted aortic arch.