Rescue of OB formation by Fez expression in OSNs
| Genotype of parents . | Genotype . | Both bulbs normal . | Partial rescue‡ . | One bulb normal† . | Abnormal bulbs* . |
|---|---|---|---|---|---|
| Fez+/–×Fez+/– | –/– | 0 | 0 | 3 | >100 |
| Fez+/–,Tg(#123p-Fez)1×Fez+/– | –/– | 0 | 0 | 0 | 4 |
| –/–, Tg+ | 0 | 2 | 1 | 2 | |
| Fez+/–,Tg(#123p-Fez)2×Fez+/–,Tg(#123p-Fez)2 | –/– | 0 | 0 | 0 | 1 |
| –/–, Tg+ | 1 | 0 | 0 | 0 | |
| Fez+/–,Tg(#123p-Fez)2×Fez+/– | –/– | 0 | 0 | 0 | 1 |
| –/–, Tg+ | 1 | 0 | 0 | 1 | |
| Fez+/–,Tg(#123p-Fez)3×Fez+/– | –/–, Tg+ | 1 | 0 | 0 | 0 |
| Genotype of parents . | Genotype . | Both bulbs normal . | Partial rescue‡ . | One bulb normal† . | Abnormal bulbs* . |
|---|---|---|---|---|---|
| Fez+/–×Fez+/– | –/– | 0 | 0 | 3 | >100 |
| Fez+/–,Tg(#123p-Fez)1×Fez+/– | –/– | 0 | 0 | 0 | 4 |
| –/–, Tg+ | 0 | 2 | 1 | 2 | |
| Fez+/–,Tg(#123p-Fez)2×Fez+/–,Tg(#123p-Fez)2 | –/– | 0 | 0 | 0 | 1 |
| –/–, Tg+ | 1 | 0 | 0 | 0 | |
| Fez+/–,Tg(#123p-Fez)2×Fez+/– | –/– | 0 | 0 | 0 | 1 |
| –/–, Tg+ | 1 | 0 | 0 | 1 | |
| Fez+/–,Tg(#123p-Fez)3×Fez+/– | –/–, Tg+ | 1 | 0 | 0 | 0 |
Fez+/– mice and Fez+/–transgenic mice containing a transgene composed of olfactory-sensory-specific#123 promoter-linked Fez expression units[Fez+/–,Tg(#123p-Fez)] were crossed as indicated,and mice with the indicated genotypes were obtained. Three different transgenic alleles [Tg(#123p-Fez)1, Tg(#123p-:Fez)2, etc.] were used. Mice were sacrificed on postnatal day one (P0) and formation of the olfactory bulb was examined by morphological inspection, immunostaining and in situ hybridization, as described in Fig. 9.
Mice that showed typical Fez–/– phenotypes in the olfactory bulbs
Mice in which one bulb, but not both, showed normal layer formation of the ONL, MCL, and GL+GCL
Mice in which the layer formation was rescued in part(s) of both bulbs