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Table 1.

Summary of phenotypes in the NB3-1 lineage

Protein gain or loss (+/−)RP neuron identity
Genotype*Total # of RPnRP1RP4RP3RP5Conclusion
Wild type  100 Wild type 
spdo mutant − Sanpodo 8.0 70 Spdo specifies RP sibling fates 
numb mutant − Numb 1.0 88 1  Numb specifies RP fates 
hb mutant − Hb (CNS) 163 Hb is required for RP1/RP4 identity 
UAS-hb + Hb 6.9 198 6.9  Hb is sufficient for RP1/4 identity 
Kr mutant − Kr (CNS) 2.7 152 0.7 Kr is required for RP3 identity 
UAS-Kr + Kr 4.3 147 2.3 Kr is sufficient for RP3 identity 
pdm mutant − Pdm 1/2 5.1 172 1.8 1.3 Pdm closes the RP3 temporal window 
UAS-pdm2 + Pdm2 2.9 142 0.6 0.3 Pdm represses RP3/RP5 identity 
cas mutant − Cas 5.6 183 2.6 Castor closes the RP5 temporal window 
UAS-cas + Cas 2.8 156 0.8 Cas represses RP5 identity 
Protein gain or loss (+/−)RP neuron identity
Genotype*Total # of RPnRP1RP4RP3RP5Conclusion
Wild type  100 Wild type 
spdo mutant − Sanpodo 8.0 70 Spdo specifies RP sibling fates 
numb mutant − Numb 1.0 88 1  Numb specifies RP fates 
hb mutant − Hb (CNS) 163 Hb is required for RP1/RP4 identity 
UAS-hb + Hb 6.9 198 6.9  Hb is sufficient for RP1/4 identity 
Kr mutant − Kr (CNS) 2.7 152 0.7 Kr is required for RP3 identity 
UAS-Kr + Kr 4.3 147 2.3 Kr is sufficient for RP3 identity 
pdm mutant − Pdm 1/2 5.1 172 1.8 1.3 Pdm closes the RP3 temporal window 
UAS-pdm2 + Pdm2 2.9 142 0.6 0.3 Pdm represses RP3/RP5 identity 
cas mutant − Cas 5.6 183 2.6 Castor closes the RP5 temporal window 
UAS-cas + Cas 2.8 156 0.8 Cas represses RP5 identity 

P<0.01 for all experiments.

*

All genotypes are described in Materials and methods.

Average number of each cell type present per hemi-segment based on markers described in Fig. 1.

We currently lack the markers to distinguish between RP1 and RP4 in functional analyses.

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