Skip to Main Content
Table 1.

Summary of the genetic experiments conducted and the resulting phenotypes

Cre used (gene deleted)Domain of expressionSingle OFT at E18.5Short OFT at E10.5Abnormal arch arteries at E10.5/E18.5AHF cell deathNCC deathAbnormal NCC localization/septation defect
Nkx2.5Cre (Shh or Smo) PE, AHF, specified myocardium, endocardium +/+ +/+ 
Wnt1-Cre (Smo) NCCs − +/+ − ?/+ 
Mef2C-Cre (Smo) AHF − −/+ − − −/+ 
TnT-Cre (Smo) Specified myocardium − − −/− ND ND ND 
Tie2-Cre (Smo) Endocardium − − −/− ND ND ND 
Cre used (gene deleted)Domain of expressionSingle OFT at E18.5Short OFT at E10.5Abnormal arch arteries at E10.5/E18.5AHF cell deathNCC deathAbnormal NCC localization/septation defect
Nkx2.5Cre (Shh or Smo) PE, AHF, specified myocardium, endocardium +/+ +/+ 
Wnt1-Cre (Smo) NCCs − +/+ − ?/+ 
Mef2C-Cre (Smo) AHF − −/+ − − −/+ 
TnT-Cre (Smo) Specified myocardium − − −/− ND ND ND 
Tie2-Cre (Smo) Endocardium − − −/− ND ND ND 

+, present; −, not present; ND, no data; ?, possibly; PE, pharyngeal endoderm; AHF, anterior heart field; NCC, neural crest cell.

Close Modal

or Create an Account

Close Modal
Close Modal