Genotypea . | % surviving tail-spike cellsb . | Average no. extra cells in anterior pharynx . |
---|---|---|
A. egl-1 is partially required for tail-spike cell death | ||
Wild type | 0±0c | 0.5±0.2d |
ced-3(n717) | 100±0 | 10.6±1.5 |
ced-4(n1162) | 100±0 | 11.1±1.1 |
egl-1(n1084n3082) | 30±6 | 11.1±1.5 |
ced-13(tm536) | 0±0 | 0.1±0.4 |
ced-13(sv32) | 0±0 | 0.2±0.4 |
egl-1(n1084n3082); ced-13(tm536) | 41±4 | 11.6±1.4 |
B. egl-1 inhibits ced-9 to promote tail-spike cell death | ||
ced-3(n2427) | 0±0 | 2.1±1.2 |
ced-9(n2812); ced-3(n2427) | 0±0 | 6.5±1.1 |
ced-3(n2427); egl-1(n1084n3082) | 100±0 | 11.2±1.8 |
ced-9(n2812); ced-3(n2427); egl-1(n1084n3082) | 0±0 | 5.2±1.8 |
C. ced-9 lacks death-promoting activity in the tail-spike cell | ||
ced-3(n2436) | 59±8 | 6.3±1.7 |
ced-9(n2812); ced-3(n2436) | 63±9 | 10.5±1.8 |
D. A ced-9(gf) mutation weakly blocks tail-spike cell death | ||
ced-9(n1950gf) | 3±3 | 10.3±1.3 |
ced-9(n1950gf); ced-3(n2427) | 50±9 | 11.5±1.1 |
ced-9(n1950gf); ced-3(n2436) | 93±5 | 11.0±1.8 |
ced-5(n1812) | 3±3 | 0.2±0.5 |
ced-9(n1950gf); ced-5(n1812) | 27±8 | 10.3±1.6 |
ced-5(n1812); ced-3(n2427)e | 17±7 | 5.1±1.8 |
ced-9(n1950gf); ced-5(n1812) ced-3(n2427)e | 73±8 | 11.1±1.5 |
ced-9(n1950gf); egl-1(n1084n3082) | 33±8 | 10.3±1.7 |
Genotypea . | % surviving tail-spike cellsb . | Average no. extra cells in anterior pharynx . |
---|---|---|
A. egl-1 is partially required for tail-spike cell death | ||
Wild type | 0±0c | 0.5±0.2d |
ced-3(n717) | 100±0 | 10.6±1.5 |
ced-4(n1162) | 100±0 | 11.1±1.1 |
egl-1(n1084n3082) | 30±6 | 11.1±1.5 |
ced-13(tm536) | 0±0 | 0.1±0.4 |
ced-13(sv32) | 0±0 | 0.2±0.4 |
egl-1(n1084n3082); ced-13(tm536) | 41±4 | 11.6±1.4 |
B. egl-1 inhibits ced-9 to promote tail-spike cell death | ||
ced-3(n2427) | 0±0 | 2.1±1.2 |
ced-9(n2812); ced-3(n2427) | 0±0 | 6.5±1.1 |
ced-3(n2427); egl-1(n1084n3082) | 100±0 | 11.2±1.8 |
ced-9(n2812); ced-3(n2427); egl-1(n1084n3082) | 0±0 | 5.2±1.8 |
C. ced-9 lacks death-promoting activity in the tail-spike cell | ||
ced-3(n2436) | 59±8 | 6.3±1.7 |
ced-9(n2812); ced-3(n2436) | 63±9 | 10.5±1.8 |
D. A ced-9(gf) mutation weakly blocks tail-spike cell death | ||
ced-9(n1950gf) | 3±3 | 10.3±1.3 |
ced-9(n1950gf); ced-3(n2427) | 50±9 | 11.5±1.1 |
ced-9(n1950gf); ced-3(n2436) | 93±5 | 11.0±1.8 |
ced-5(n1812) | 3±3 | 0.2±0.5 |
ced-9(n1950gf); ced-5(n1812) | 27±8 | 10.3±1.6 |
ced-5(n1812); ced-3(n2427)e | 17±7 | 5.1±1.8 |
ced-9(n1950gf); ced-5(n1812) ced-3(n2427)e | 73±8 | 11.1±1.5 |
ced-9(n1950gf); egl-1(n1084n3082) | 33±8 | 10.3±1.7 |
aAll strains also contained the nsls25 or nsls23 C. briggsae ced-3 promoter::GFP integrated transgenes for scoring tail-spike cell survival. bBetween 20-40 L4 or L2 animals were scored for survival of pharyngeal or tail-spike cells, respectively, for each genotype. cStandard error of the mean. dMean±standard deviation. eContains unc-30(e191).