Correlation between regions of RA production in the developing chick embryo and known sites of Cyp1B1 and Raldh1-3expression
| Retinoid-producing tissue* . | Raldh1-3 expression in tissue† . | Cyp1B1 expression in tissue‡ . |
|---|---|---|
| HH4/5 chick embryos | ||
| Posterior end of embryo | √ (2 and 3) | √ |
| HH10-12 chick embryos | ||
| Somites 1-3 | × | √ |
| Somites 3-8 | √ (2) | √ |
| Heart (low) | √ (2 and 3) | √ |
| Forebrain mesenchyme | × (3: in epithelium) | √ |
| Midbrain mesenchyme | × | √ |
| Hindbrain mesenchyme | × | √ |
| Spinal neural tube | × | × |
| HH15 chick embryos | ||
| Branchial arches (low) | × | √ |
| Heart (low) | √ (2) | √ |
| Somites | √ (2) | √ |
| Lateral plate | √ (2) | × |
| HH20 chick embryos | ||
| Hindbrain mesenchyme | × | √ |
| Somites | √ (2) | √ |
| Spinal neural tube | √ (2: motor neurons and roof plate) | × |
| HH24 chick embryos | ||
| Branchial arches (low) | √ (2: first branchial groove) | √ |
| Heart (low) | √ (2 and 3) | √ |
| Posterior limb bud | × | √ |
| Eye | √ (1, 2 and 3) | √ |
| Somites | √ (2) | √ |
| Hindbrain mesenchyme | × | √ |
| Midbrain mesenchyme | × | √ |
| Forebrain mesenchyme | √ (2: mesenchyme next to eye) | √ |
| Retinoid-producing tissue* . | Raldh1-3 expression in tissue† . | Cyp1B1 expression in tissue‡ . |
|---|---|---|
| HH4/5 chick embryos | ||
| Posterior end of embryo | √ (2 and 3) | √ |
| HH10-12 chick embryos | ||
| Somites 1-3 | × | √ |
| Somites 3-8 | √ (2) | √ |
| Heart (low) | √ (2 and 3) | √ |
| Forebrain mesenchyme | × (3: in epithelium) | √ |
| Midbrain mesenchyme | × | √ |
| Hindbrain mesenchyme | × | √ |
| Spinal neural tube | × | × |
| HH15 chick embryos | ||
| Branchial arches (low) | × | √ |
| Heart (low) | √ (2) | √ |
| Somites | √ (2) | √ |
| Lateral plate | √ (2) | × |
| HH20 chick embryos | ||
| Hindbrain mesenchyme | × | √ |
| Somites | √ (2) | √ |
| Spinal neural tube | √ (2: motor neurons and roof plate) | × |
| HH24 chick embryos | ||
| Branchial arches (low) | √ (2: first branchial groove) | √ |
| Heart (low) | √ (2 and 3) | √ |
| Posterior limb bud | × | √ |
| Eye | √ (1, 2 and 3) | √ |
| Somites | √ (2) | √ |
| Hindbrain mesenchyme | × | √ |
| Midbrain mesenchyme | × | √ |
| Forebrain mesenchyme | √ (2: mesenchyme next to eye) | √ |
×, sites where RA has been described but expression of either Cyp1B1 or Raldh genes is missing.
√, sites where there is concordance between expression and RA accumulation.
The bracketed number indicates which member(s) of the Raldh family is represented in that region.
Data on RA distribution are taken from Maden et al.(Maden et al., 1998).
e.g. Blentic et al. (Blentic et al.,2003).
Figs 1, 3, 6 and data not shown.