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Table 1.

Correlation between regions of RA production in the developing chick embryo and known sites of Cyp1B1 and Raldh1-3expression

Retinoid-producing tissue*Raldh1-3 expression in tissueCyp1B1 expression in tissue
HH4/5 chick embryos   
Posterior end of embryo √ (2 and 3) √ 
HH10-12 chick embryos   
Somites 1-3 × √ 
Somites 3-8 √ (2) √ 
Heart (low) √ (2 and 3) √ 
Forebrain mesenchyme × (3: in epithelium) √ 
Midbrain mesenchyme × √ 
Hindbrain mesenchyme × √ 
Spinal neural tube × × 
HH15 chick embryos   
Branchial arches (low) × √ 
Heart (low) √ (2) √ 
Somites √ (2) √ 
Lateral plate √ (2) × 
HH20 chick embryos   
Hindbrain mesenchyme × √ 
Somites √ (2) √ 
Spinal neural tube √ (2: motor neurons and roof plate) × 
HH24 chick embryos   
Branchial arches (low) √ (2: first branchial groove) √ 
Heart (low) √ (2 and 3) √ 
Posterior limb bud × √ 
Eye √ (1, 2 and 3) √ 
Somites √ (2) √ 
Hindbrain mesenchyme × √ 
Midbrain mesenchyme × √ 
Forebrain mesenchyme √ (2: mesenchyme next to eye) √ 
Retinoid-producing tissue*Raldh1-3 expression in tissueCyp1B1 expression in tissue
HH4/5 chick embryos   
Posterior end of embryo √ (2 and 3) √ 
HH10-12 chick embryos   
Somites 1-3 × √ 
Somites 3-8 √ (2) √ 
Heart (low) √ (2 and 3) √ 
Forebrain mesenchyme × (3: in epithelium) √ 
Midbrain mesenchyme × √ 
Hindbrain mesenchyme × √ 
Spinal neural tube × × 
HH15 chick embryos   
Branchial arches (low) × √ 
Heart (low) √ (2) √ 
Somites √ (2) √ 
Lateral plate √ (2) × 
HH20 chick embryos   
Hindbrain mesenchyme × √ 
Somites √ (2) √ 
Spinal neural tube √ (2: motor neurons and roof plate) × 
HH24 chick embryos   
Branchial arches (low) √ (2: first branchial groove) √ 
Heart (low) √ (2 and 3) √ 
Posterior limb bud × √ 
Eye √ (1, 2 and 3) √ 
Somites √ (2) √ 
Hindbrain mesenchyme × √ 
Midbrain mesenchyme × √ 
Forebrain mesenchyme √ (2: mesenchyme next to eye) √ 

×, sites where RA has been described but expression of either Cyp1B1 or Raldh genes is missing.

√, sites where there is concordance between expression and RA accumulation.

The bracketed number indicates which member(s) of the Raldh family is represented in that region.

*

Data on RA distribution are taken from Maden et al.(Maden et al., 1998).

e.g. Blentic et al. (Blentic et al.,2003).

Figs 1, 3, 6 and data not shown.

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