The Company of Biologists

Table 2.

Cell cycle analysis of cD1^−/− and cD2^−/− MGE compared with WT

		BrdU (1-hour pulse)	p27	pRB	Q fraction (24 hour BrdU/Ki67)	cD1	cD2
cD1^−/−	VZ	↓^{^*}	↓	↔	↑↓^{^†}	0	↑
	SVZ	↔	↑↓	↔	↓^{^†}	0	↑
cD2^−/−	VZ	↔	↑	↓	↔	↑	0
	SVZ	↓	↑	↓	↑	↔	0

		BrdU (1-hour pulse)	p27	pRB	Q fraction (24 hour BrdU/Ki67)	cD1	cD2
cD1^−/−	VZ	↓^{^*}	↓	↔	↑↓^{^†}	0	↑
	SVZ	↔	↑↓	↔	↓^{^†}	0	↑
cD2^−/−	VZ	↔	↑	↓	↔	↑	0
	SVZ	↓	↑	↓	↑	↔	0

Trend toward 15-20% reduction, not statistically significant (n=5 cD1^−/− versus 3 WT).

Indicated by increased Ki67 and equivalent BrdU labeling of cD1^−/− versus WT littermates.