External ear phenotype in Sox3; Fgfr1 double mutants
| . | Affected ear . | . | . | . | |||
|---|---|---|---|---|---|---|---|
| Genotype . | Right . | Left . | Both . | %total defect . | |||
| Fgfr1n7/+ | - | - | - | 0.0 (n=24) | |||
| Sox3+/− | - | - | - | 0.0 (n=24) | |||
| Sox3−/γ or Sox3−/− | 1 | 2 | - | 18.8 (n=16) | |||
| Sox3+/−; Fgfr1n7/+ | 2 | 4 | 2 | 20.5 (n=39) | |||
| Sox3−/γ or Sox−/−; Fgfr1n7/+ | 1 | 1 | 7 | 90 (n=10) | |||
| . | Affected ear . | . | . | . | |||
|---|---|---|---|---|---|---|---|
| Genotype . | Right . | Left . | Both . | %total defect . | |||
| Fgfr1n7/+ | - | - | - | 0.0 (n=24) | |||
| Sox3+/− | - | - | - | 0.0 (n=24) | |||
| Sox3−/γ or Sox3−/− | 1 | 2 | - | 18.8 (n=16) | |||
| Sox3+/−; Fgfr1n7/+ | 2 | 4 | 2 | 20.5 (n=39) | |||
| Sox3−/γ or Sox−/−; Fgfr1n7/+ | 1 | 1 | 7 | 90 (n=10) | |||
Defects were monitored after weaning on littermates obtained either from Fgfr1n7/+ mated with Sox3−/γ or Sox3+/−; Fgfr1n7/+ mated with Sox3−/γ. Introduction of the hypomorphic Fgfr1 allele leads to the appearance of defects in Sox3+/− females and increases their penetrance in Sox3−/γ and Sox3−/− animals.