Skip to Main Content
Table 1.

Details of genes involved in the meiotic division of germ cells in the mouse

Gene (common aliases)Encoded protein and functionMouse mutant phenotype (male)Mouse mutant phenotype (female)Expression pattern in mouse fetal gonadsReferences
Cyp26b1 (CP26, P450RAI-2) Cytochrome P450, family 26, subfamily b, polypeptide 1; P450 enzyme, degrades RA to inactive metabolites Die at birth, various developmental defects, germ cells express Stra8and Scp3 ectopically and enter meiosis during fetal life Die at birth, various developmental defects, germ cells express Stra8prematurely Expressed in somatic cells of both sexes from at least 11.5 dpc then upregulated in testis and down-regulated in ovary (MacLean et al., 2001; Menke and Page, 2002; Bowles et al., 2006; White et al., 2000; Yashiro et al., 2004; MacLean et al., 2007) 
Dmc1 (Dmc1h) Homolog of yeast Disrupted meiotic cDNA 1, dosage suppressor of mck 1 homolog,meiosis-specific homolog of bacterial RecA; ssDNA and dsDNA binding protein,repairs DSBs Sterile, germ cells arrest at zygotene-like stage of meiosis I and then undergo apoptosis. Chromosomal synapsis is not initiated Sterile, germ cells arrested at pre-pachytene stage, germ cells apoptose and the ovary degenerates Expressed pre-meiotically in germ cells of both sexes at a low level, then upregulated in ovary in an A/P wave from ∼13.5 dpc (Chuma and Nakatsuji, 2001; Menke et al., 2003; Nakatsuji and Chuma, 2001;Pittman et al., 1998; Yoshida et al., 1998) 
Pou5f1 (Oct4, Oct3/4) POU domain, class 5, transcription factor; considered a master regulator of pluripotency, maintains viability of mammalian germ line Male and female null develop to blastocyst stage and die at implantation. In germ cell-specific nulls, XY and XX germ cells undergo apoptosis between 9.5 and 10.5 dpc, before colonization of the gonad  In female PGCs: repressed during meiotic prophase I. In male PGCs: expressed throughout fetal life (Bullejos and Koopman, 2004; Kehler et al., 2004; Nichols et al., 1998; Pesce et al., 1998; Wang et al., 2006) 
Stra8 Stimulated by retinoic acid, gene 8; cytoplasmic protein, required for pre-meiotic DNA replication and the subsequent events of meiotic prophase Infertile, pre-meiotic spermatocytes appear and show chromosomal condensation but do not enter prophase of meiosis I. Germ cell number reduced Infertile, germ cells develop pre-meiotic morphology but do not enter prophase of meiosis I. By birth, ovaries are severely depleted of germ cells Expressed exclusively in pre-meiotic germ cells (spermatogonia and possibly preleptotene spermatocytes). In embryonic ovary an A/P wave initiates at∼12.5 dpc (Baltus et al., 2006; Menke et al., 2003; Oulad-Abdelghani et al., 1996) 
Sycp3 (Scp3, Cor1) Synaptonemal complex protein; structural protein, main constituent of the axial elements of the synaptonemal complex Sterile, axial elements fail to form and germ cells die by apoptosis Sub-fertile, germ cell aneuploidy (trisomy or monosomy) due to defective meiotic chromosome segregation Expressed pre-meiotically in germ cells of both sexes at a low level, then upregulated in ovary in an A/P wave from ∼13.5 dpc (Bullejos and Koopman, 2004; Chuma and Nakatsuji, 2001; Nakatsuji and Chuma,2001; Yao et al., 2003; Yuan et al., 2000; Yuan et al., 2002) 
Gene (common aliases)Encoded protein and functionMouse mutant phenotype (male)Mouse mutant phenotype (female)Expression pattern in mouse fetal gonadsReferences
Cyp26b1 (CP26, P450RAI-2) Cytochrome P450, family 26, subfamily b, polypeptide 1; P450 enzyme, degrades RA to inactive metabolites Die at birth, various developmental defects, germ cells express Stra8and Scp3 ectopically and enter meiosis during fetal life Die at birth, various developmental defects, germ cells express Stra8prematurely Expressed in somatic cells of both sexes from at least 11.5 dpc then upregulated in testis and down-regulated in ovary (MacLean et al., 2001; Menke and Page, 2002; Bowles et al., 2006; White et al., 2000; Yashiro et al., 2004; MacLean et al., 2007) 
Dmc1 (Dmc1h) Homolog of yeast Disrupted meiotic cDNA 1, dosage suppressor of mck 1 homolog,meiosis-specific homolog of bacterial RecA; ssDNA and dsDNA binding protein,repairs DSBs Sterile, germ cells arrest at zygotene-like stage of meiosis I and then undergo apoptosis. Chromosomal synapsis is not initiated Sterile, germ cells arrested at pre-pachytene stage, germ cells apoptose and the ovary degenerates Expressed pre-meiotically in germ cells of both sexes at a low level, then upregulated in ovary in an A/P wave from ∼13.5 dpc (Chuma and Nakatsuji, 2001; Menke et al., 2003; Nakatsuji and Chuma, 2001;Pittman et al., 1998; Yoshida et al., 1998) 
Pou5f1 (Oct4, Oct3/4) POU domain, class 5, transcription factor; considered a master regulator of pluripotency, maintains viability of mammalian germ line Male and female null develop to blastocyst stage and die at implantation. In germ cell-specific nulls, XY and XX germ cells undergo apoptosis between 9.5 and 10.5 dpc, before colonization of the gonad  In female PGCs: repressed during meiotic prophase I. In male PGCs: expressed throughout fetal life (Bullejos and Koopman, 2004; Kehler et al., 2004; Nichols et al., 1998; Pesce et al., 1998; Wang et al., 2006) 
Stra8 Stimulated by retinoic acid, gene 8; cytoplasmic protein, required for pre-meiotic DNA replication and the subsequent events of meiotic prophase Infertile, pre-meiotic spermatocytes appear and show chromosomal condensation but do not enter prophase of meiosis I. Germ cell number reduced Infertile, germ cells develop pre-meiotic morphology but do not enter prophase of meiosis I. By birth, ovaries are severely depleted of germ cells Expressed exclusively in pre-meiotic germ cells (spermatogonia and possibly preleptotene spermatocytes). In embryonic ovary an A/P wave initiates at∼12.5 dpc (Baltus et al., 2006; Menke et al., 2003; Oulad-Abdelghani et al., 1996) 
Sycp3 (Scp3, Cor1) Synaptonemal complex protein; structural protein, main constituent of the axial elements of the synaptonemal complex Sterile, axial elements fail to form and germ cells die by apoptosis Sub-fertile, germ cell aneuploidy (trisomy or monosomy) due to defective meiotic chromosome segregation Expressed pre-meiotically in germ cells of both sexes at a low level, then upregulated in ovary in an A/P wave from ∼13.5 dpc (Bullejos and Koopman, 2004; Chuma and Nakatsuji, 2001; Nakatsuji and Chuma,2001; Yao et al., 2003; Yuan et al., 2000; Yuan et al., 2002) 

A/P; anterior/posterior; dpc, days post coitum; DSB, double-strand break;ss, single-stranded; ds, double-stranded.

Close Modal

or Create an Account

Close Modal
Close Modal