Summary of the general phenotypes of Sulf mutant mice
| Genotype . | % ISMS* . | % Survival . | Adult body weight . | Fertility . |
|---|---|---|---|---|
| Wild type | 29±3.3 | 100 | Normal | Normal |
| Sulf1−/− | 38±4.2† | 100 | Normal | Normal |
| Sulf2−/− | 33±0.7 | 100 | ∼90% | Normal |
| Sulf1+/−;Sulf2+/− | 34±0.7 | 100 | Normal | Normal |
| Sulf1−/−;Sulf2+/− | 46±3.1† | 100 | ND | Normal |
| Sulf1+/−;Sulf2−/− | 59† | ∼90 | 70-90% | Reduced‡ |
| Sulf1−/−;Sulf2−/− | 61±5.1† | 100 at birth, 45 at P21 | 40-70% | Much reduced§ |
| Genotype . | % ISMS* . | % Survival . | Adult body weight . | Fertility . |
|---|---|---|---|---|
| Wild type | 29±3.3 | 100 | Normal | Normal |
| Sulf1−/− | 38±4.2† | 100 | Normal | Normal |
| Sulf2−/− | 33±0.7 | 100 | ∼90% | Normal |
| Sulf1+/−;Sulf2+/− | 34±0.7 | 100 | Normal | Normal |
| Sulf1−/−;Sulf2+/− | 46±3.1† | 100 | ND | Normal |
| Sulf1+/−;Sulf2−/− | 59† | ∼90 | 70-90% | Reduced‡ |
| Sulf1−/−;Sulf2−/− | 61±5.1† | 100 at birth, 45 at P21 | 40-70% | Much reduced§ |
ND, Not determined.
The percentage of total O-35S-labeled disaccharides generated after deaminative cleavage (pH 1.5) of purified HS. The M in ISMS(IdoA2S-GlcNS6S) stands for the 2,5-anhydromannitol deamination products of GlcNS residues.
P<0.01.
Reduced in both sexes: the average litter size was 4-6, compared with the normal 8-10.
Much reduced in both sexes: the average litter size was 2-4.