Tgfβ targets upregulated in retinoic acid-deficient foreguts
| . | WT (BMS493/Ctrl) . | . | Raldh2−/− (Ctrl/RA) . | . | . | ||
|---|---|---|---|---|---|---|---|
| Gene . | FC* . | P . | FC# . | P . | References . | ||
| Atf3 | 1.5 | 2×10−3 | 1.6 | 8×10−5 | (Kang et al., 2003; Yun et al., 2002) | ||
| Bgn | 2.5 | 1×10−4 | 2.5 | 2×10−5 | (Benson et al., 2002; Chen et al., 2002; Groth et al., 2005; Ungefroren et al., 2003) | ||
| Cd44 | 1.8 | 5×10−5 | 1.5 | 7×10−3 | (Verrecchia et al., 2001) | ||
| Cdc42 | 1.7 | 2×10−5 | 1.3 | 1×10−2 | (Verrecchia et al., 2001) | ||
| Col1a2 | 2.1 | 2×10−5 | 2.0 | 5×10−5 | (Benson et al., 2002; Kapoun et al., 2004; Okano et al., 2006; Verrecchia et al., 2001) | ||
| Col3a1 | 1.2 | 2×10−2 | 3.5 | 8×10−3 | (Benson et al., 2002; Bertelli et al., 1998; Verrecchia et al., 2001) | ||
| Csf1 | 1.7 | 3×10−3 | 1.5 | 1×10−2 | (Xie et al., 2003) | ||
| Ctgf | 3.6 | 1×10−9 | 1.3 | 3×10−2 | (Benson et al., 2002; Colwell et al., 2006; de Jong et al., 2002; Kapoun et al., 2004) | ||
| Cyr61 | 1.4 | 1×10−3 | 1.7 | 8×10−7 | (Bartholin et al., 2007; Benson et al., 2002; de Jong et al., 2002; Leivonen et al., 2005) | ||
| igfbp4 | 1.6 | 3×10−3 | 1.3 | 8×10−4 | (Benson et al., 2002; Dahlfors and Arnqvist, 2000; Verrecchia et al., 2001) | ||
| Pcolce | 1.6 | 2×10−5 | 1.4 | 4×10−4 | (Shalitin et al., 2003) | ||
| Sparc | 1.5 | 1×10−4 | 1.2 | 9×10−3 | (Benson et al., 2002; Fujita et al., 2002; Pavasant et al., 2003) | ||
| Spp1 | 8.8 | 2×10−4 | 3.3 | 2×10−2 | (Benson et al., 2002; Sodek et al., 1995) | ||
| Tgfbi | 4.1 | 2×10−10 | 8.7 | 6×10−14 | (Benson et al., 2002; LeBaron et al., 1995; Schneider et al., 2002; Skonier et al., 1994) | ||
| Timp1 | 1.4 | 6×10−3 | 1.9 | 5×10−5 | (Verrecchia et al., 2001) | ||
| Timp3 | 1.3 | 3×10−2 | 1.5 | 8×10−3 | (de Jong et al., 2002; Kapoun et al., 2004; Verrecchia et al., 2001) | ||
| . | WT (BMS493/Ctrl) . | . | Raldh2−/− (Ctrl/RA) . | . | . | ||
|---|---|---|---|---|---|---|---|
| Gene . | FC* . | P . | FC# . | P . | References . | ||
| Atf3 | 1.5 | 2×10−3 | 1.6 | 8×10−5 | (Kang et al., 2003; Yun et al., 2002) | ||
| Bgn | 2.5 | 1×10−4 | 2.5 | 2×10−5 | (Benson et al., 2002; Chen et al., 2002; Groth et al., 2005; Ungefroren et al., 2003) | ||
| Cd44 | 1.8 | 5×10−5 | 1.5 | 7×10−3 | (Verrecchia et al., 2001) | ||
| Cdc42 | 1.7 | 2×10−5 | 1.3 | 1×10−2 | (Verrecchia et al., 2001) | ||
| Col1a2 | 2.1 | 2×10−5 | 2.0 | 5×10−5 | (Benson et al., 2002; Kapoun et al., 2004; Okano et al., 2006; Verrecchia et al., 2001) | ||
| Col3a1 | 1.2 | 2×10−2 | 3.5 | 8×10−3 | (Benson et al., 2002; Bertelli et al., 1998; Verrecchia et al., 2001) | ||
| Csf1 | 1.7 | 3×10−3 | 1.5 | 1×10−2 | (Xie et al., 2003) | ||
| Ctgf | 3.6 | 1×10−9 | 1.3 | 3×10−2 | (Benson et al., 2002; Colwell et al., 2006; de Jong et al., 2002; Kapoun et al., 2004) | ||
| Cyr61 | 1.4 | 1×10−3 | 1.7 | 8×10−7 | (Bartholin et al., 2007; Benson et al., 2002; de Jong et al., 2002; Leivonen et al., 2005) | ||
| igfbp4 | 1.6 | 3×10−3 | 1.3 | 8×10−4 | (Benson et al., 2002; Dahlfors and Arnqvist, 2000; Verrecchia et al., 2001) | ||
| Pcolce | 1.6 | 2×10−5 | 1.4 | 4×10−4 | (Shalitin et al., 2003) | ||
| Sparc | 1.5 | 1×10−4 | 1.2 | 9×10−3 | (Benson et al., 2002; Fujita et al., 2002; Pavasant et al., 2003) | ||
| Spp1 | 8.8 | 2×10−4 | 3.3 | 2×10−2 | (Benson et al., 2002; Sodek et al., 1995) | ||
| Tgfbi | 4.1 | 2×10−10 | 8.7 | 6×10−14 | (Benson et al., 2002; LeBaron et al., 1995; Schneider et al., 2002; Skonier et al., 1994) | ||
| Timp1 | 1.4 | 6×10−3 | 1.9 | 5×10−5 | (Verrecchia et al., 2001) | ||
| Timp3 | 1.3 | 3×10−2 | 1.5 | 8×10−3 | (de Jong et al., 2002; Kapoun et al., 2004; Verrecchia et al., 2001) | ||
FC*, fold change ratio between the expression levels in BMS493-treated and untreated WT foreguts.
FC#, fold change ratio between the expression levels in untreated and RA-treated Raldh2−/− foreguts.