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Table 1.

Mendelian ratios of the Egfl7-knockout lines

Ratios for each genotype
Observed % (n)
Expected % (n)
Genetic background (generation)Genotype
Genotype
Total number of animals analyzed (n)P values of observed vs expected (−/−) ratios(ϰ2 test)
Knockout lineAge+/++/−−/−+/++/−−/−
Insertional knockout 129svj/C57Bl/6 mixed Adult 33.1 (115) 53.3 (185) 13.5 (47) 25 (87) 50 (173) 25 (87) 347 <0.0001* 
 129svj/C57Bl/6 mixed P0-8 33.2 (68) 53.7 (110) 13.1 (27) 25 (51) 50 (103) 25 (51) 205 <0.0001* 
 129svj/C57Bl/6 mixed E9.5-15.5 24 (62) 51.2 (132) 24.8 (64) 25 (64.5) 50 (129) 25 (64.5) 258 0.9185 
Homologous recombination knockout C57Bl/6 (N5) Adult 33.9 (96) 52 (147) 14.1 (40) 25 (71) 50 (141) 25 (71) 283 <0.0001* 
 C57Bl/6 (N10) Adult 31.5 (73) 59 (137) 9.5 (22) 25 (58) 50 (116) 25 (58) 232 <0.0001* (0.0921 N10 vs N5) 
 129svj Pure Adult 36.6 (30) 48.8 (40) 14.6 (12) 25 (20.5) 50 (41) 25 (20.5) 82 0.0188* 
 C57Bl/6 (N5) P0-8 31.7 (91) 54.7 (157) 13.6 (39) 25 (72) 50 (143) 25 (72) 287 <0.0001* 
 C57Bl/6 (N0-5) E9.5-15.5 28.5 (84) 46.1 (136) 25.4 (75) 25 (74) 50 (147) 25 (74) 295 0.3104 
Ratios for each genotype
Observed % (n)
Expected % (n)
Genetic background (generation)Genotype
Genotype
Total number of animals analyzed (n)P values of observed vs expected (−/−) ratios(ϰ2 test)
Knockout lineAge+/++/−−/−+/++/−−/−
Insertional knockout 129svj/C57Bl/6 mixed Adult 33.1 (115) 53.3 (185) 13.5 (47) 25 (87) 50 (173) 25 (87) 347 <0.0001* 
 129svj/C57Bl/6 mixed P0-8 33.2 (68) 53.7 (110) 13.1 (27) 25 (51) 50 (103) 25 (51) 205 <0.0001* 
 129svj/C57Bl/6 mixed E9.5-15.5 24 (62) 51.2 (132) 24.8 (64) 25 (64.5) 50 (129) 25 (64.5) 258 0.9185 
Homologous recombination knockout C57Bl/6 (N5) Adult 33.9 (96) 52 (147) 14.1 (40) 25 (71) 50 (141) 25 (71) 283 <0.0001* 
 C57Bl/6 (N10) Adult 31.5 (73) 59 (137) 9.5 (22) 25 (58) 50 (116) 25 (58) 232 <0.0001* (0.0921 N10 vs N5) 
 129svj Pure Adult 36.6 (30) 48.8 (40) 14.6 (12) 25 (20.5) 50 (41) 25 (20.5) 82 0.0188* 
 C57Bl/6 (N5) P0-8 31.7 (91) 54.7 (157) 13.6 (39) 25 (72) 50 (143) 25 (72) 287 <0.0001* 
 C57Bl/6 (N0-5) E9.5-15.5 28.5 (84) 46.1 (136) 25.4 (75) 25 (74) 50 (147) 25 (74) 295 0.3104 

The offspring of multiple pairs of Egfl7+/−parents in different genetic background were genotyped and counted. The N values refer to how many generations the mutant mice in the 129svj/C57Bl/6 mixed background have been crossed to C57Bl/6 mice. Values in bold are statistically significant (*).

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