Vertebrate gene . | Auditory, vestibular hair cell orientation . | Neural tube closure . | Convergent extension . | Eyelid closure . | Hair patterning . | Axon growth, guidance . | Hindbrain neuron migration . | Dendritic arborization . |
---|---|---|---|---|---|---|---|---|
Bbs1† | D | - | - | - | - | - | - | - |
Bbs4† | D | D | (D) | - | - | - | - | - |
Bbs6† | D | - | (D) | - | - | - | - | - |
Celsr1 | D | D | - | D | - | - | (D) | - |
Celsr2 | - | - | - | - | - | - | D | D |
Celsr3 | - | - | - | - | - | D | - | - |
Dvl1 | D* | D* | D* | - | - | - | - | D |
Dvl2 | D* | D* | D* | - | - | - | - | - |
Dvl3 | - | D* | - | - | - | - | - | - |
Fuzzy† | - | - | D | - | - | - | - | - |
Fz3 | D* | D* | D* | (D*) | - | D | D | - |
Fz6 | D* | D* | D* | (D*) | D | - | - | - |
Inturned† | - | - | D | - | - | - | - | - |
Inversin | - | - | D | - | D | - | - | - |
Prickle-1 | - | - | D | - | - | - | D | - |
Ptk7 | D | D | - | D | - | - | - | - |
Scribble | D | D | D | - | - | - | D | - |
Vangl2 | D | D | D | D | - | - | D | - |
Widerborst | - | - | D | - | - | - | - | - |
Vertebrate gene . | Auditory, vestibular hair cell orientation . | Neural tube closure . | Convergent extension . | Eyelid closure . | Hair patterning . | Axon growth, guidance . | Hindbrain neuron migration . | Dendritic arborization . |
---|---|---|---|---|---|---|---|---|
Bbs1† | D | - | - | - | - | - | - | - |
Bbs4† | D | D | (D) | - | - | - | - | - |
Bbs6† | D | - | (D) | - | - | - | - | - |
Celsr1 | D | D | - | D | - | - | (D) | - |
Celsr2 | - | - | - | - | - | - | D | D |
Celsr3 | - | - | - | - | - | D | - | - |
Dvl1 | D* | D* | D* | - | - | - | - | D |
Dvl2 | D* | D* | D* | - | - | - | - | - |
Dvl3 | - | D* | - | - | - | - | - | - |
Fuzzy† | - | - | D | - | - | - | - | - |
Fz3 | D* | D* | D* | (D*) | - | D | D | - |
Fz6 | D* | D* | D* | (D*) | D | - | - | - |
Inturned† | - | - | D | - | - | - | - | - |
Inversin | - | - | D | - | D | - | - | - |
Prickle-1 | - | - | D | - | - | - | D | - |
Ptk7 | D | D | - | D | - | - | - | - |
Scribble | D | D | D | - | - | - | D | - |
Vangl2 | D | D | D | D | - | - | D | - |
Widerborst | - | - | D | - | - | - | - | - |
Phenotypes associated with PCP genes in vertebrates: D, defective; (D),defective, but either low penetrance or observed as an increase in the severity of the phenotype of another PCP mutation; D*, defective only in a double mutant combination (i.e. redundancy between gene family members); -, not reported as abnormal. For some of these genes, one or more of the listed characteristics may not have been examined or examined in sufficient detail to determine whether it is normal; thus, a - entry should be interpreted cautiously.
References: Bbs1, Bbs4, Bbs6(Ross et al., 2005); Celsr1 (Curtin et al.,2003); Celsr2 (Shima et al., 2004; Kimura et al.,2006; Wada et al.,2006); Celsr3 (Tisser et al., 2005; Price et al., 2006); Dvl1,Dvl2, Dvl3 (Hamblet et al.,2002; Rosso et al.,2005; Wang et al.,2005; Wang, J. et al.,2006); Fuzzy (Park et al., 2006); Fz3(Wang et al., 2002; Wang et al., 2006a; Wang et al., 2006b; Wada et al., 2006); Fz6 (Guo et al.,2004; Wang et al.,2006b; Wang et al.,2006c); Inturned(Park et al., 2006); Inversin (Otto et al.,2003; Simons et al.,2005); Prickle-1(Carreira-Barbosa et al.,2003; Veeman et al.,2003); Ptk7 (Lu et al., 2004); Scribble(Murdoch et al., 2003; Montcouquiol et al., 2003; Wada et al., 2005); Vangl2 (Greene et al.,1998; Kibar et al.,2001; Murdoch et al.,2001; Bingham et al.,2002; Jessen et al.,2002; Montcouquiol et al.,2003; Torban et al., 2004); Widerborst(Hannus et al., 2002).
Implicated in ciliary function.