Genes differentially expressed in human skin fibroblasts in UVB-induced SIPS
| Gene . | Name . | UVB/CTL . | Function . | GenBank . |
|---|---|---|---|---|
| IGF-BP3 | insulin growth factor binding protein 3 | ↑ 2,7 | growth factor | X64875 |
| HSP70 | heat shock 70 kD protein 1 | ↑ 2,5 | defense system | AB023420 |
| HMOX | heme-oxygenase | ↑ 2,4 | defense system | NM_002133 |
| IL-1B | interleukin 1 beta | ↑ 2,4 | cytokine | M15330 |
| OSTE | osteonectin | ↑ 2,4 | extracellular matrix | NM_003118 |
| ODC | ornithine decarboxylase 1 | ↑ 2,3 | cell cycle | NM_002539 |
| HSP90A | heat shock 90 kD protein 1 alpha | ↑ 2,3 | defense system | X15183 |
| COL1A1 | collagen 1 alpha-1 | ↑ 2,2 | extracellular matrix | NM_000088 |
| MAX | MAX protein | ↑ 2,2 | cell cycle | NM_002382 |
| CTGF | connective tissue growth factor | ↑ 2,1 | cell cycle | U14750 |
| PCNA | proliferating cell nuclear antigen | ↑ 2,1 | control of DNA replication | NM002592 |
| TPA | plasminogen activator tissue | ↑ 2,1 | extracellular matrix | NM_000930 |
| CCND-1 | cyclin D1 | ↑ 2,1 | cell cycle | NM_053056 |
| MMP-1 | matrix metalloproteinase 1 | ↑ 2,1 | degradation of extracellular matrix | NM_002421 |
| MT2A | metallothionein 2A | ↑ 2 | defense system | V00594 |
| APO J | apolipoprotein J | ↑ 2 | defense system | J02908 |
| COL3A1 | collagen 3 alpha-1 | ↑ 2 | extracellular matrix | NM_000090 |
| HSP40 | heat shock 40 kD protein 1 | ↑ 2 | defense system | D49547 |
| MEK-1 | mitogen activated protein kinase kinase 1 | ↑ 2 | cell cycle | L11284 |
| p21 | cyclin dependent kinase inhibitor 1A | ↑ 1,9 | cell cycle | U03106 |
| NRG-1 | neuregulin | ↑ 1,9 | cell cycle | M94165 |
| FN1 | fibronectin | ↑ 1,9 | extracellular matrix | X02761 |
| TGFβRII | transforming growth factor-beta receptor II | ↑ 1,9 | growth factor | D50685 |
| Il-11 | interleukin 11 | ↑ 1,8 | cytokine | NM_000641 |
| MMP-2 | matrix metalloproteinase 2 | ↑ 1,8 | degradation of extracellular matrix | NM_004530 |
| ANX-1 | annexin 1 | ↑ 1,8 | anti-inflammatory | NM_000700 |
| HSP70B | heat shock 70 kD protein 6 | ↑ 1,8 | defense system | NM_002155 |
| IGF-BP5 | insulin growth factor binding protein 5 | ↑ 1,8 | growth factor | M65062 |
| JNK-2 | mitogen activated protein kinase 9 | ↑ 1,8 | defense system | U09759 |
| CANX | calnexin | ↑ 1,8 | cell cycle | NM_001746 |
| HSP27 | heat shock 27 kD protein 1 | ↑ 1,8 | defense system | AB020027 |
| EF1A | eucaryotic translation elongation factor-alpha | ↑ 1,7 | protein synthesis | AY043301 |
| PRX VI | peroxiredoxin VI | ↑ 1,7 | defense system | NM_004905 |
| MDM2 | MDM2 | ↑ 1,7 | cell cycle | NM_002392 |
| GPX | glutathion peroxidase | ↑ 1,6 | defense system | M21304 |
| H2BS | histone 2B member B/S consensus | ↑ 1,6 | cell cycle | NM_080593 |
| CCNH | cyclin H | ↑ 1,6 | cell cycle | NM_001239 |
| FMOD | fibromodulin | ↓ 0,6 | extracellular matrix | NM_002023 |
| ICAM-1 | intracellular adhesion molecule 1 | ↓ 0,3 | extracellular matrix | J031032 |
| Gene . | Name . | UVB/CTL . | Function . | GenBank . |
|---|---|---|---|---|
| IGF-BP3 | insulin growth factor binding protein 3 | ↑ 2,7 | growth factor | X64875 |
| HSP70 | heat shock 70 kD protein 1 | ↑ 2,5 | defense system | AB023420 |
| HMOX | heme-oxygenase | ↑ 2,4 | defense system | NM_002133 |
| IL-1B | interleukin 1 beta | ↑ 2,4 | cytokine | M15330 |
| OSTE | osteonectin | ↑ 2,4 | extracellular matrix | NM_003118 |
| ODC | ornithine decarboxylase 1 | ↑ 2,3 | cell cycle | NM_002539 |
| HSP90A | heat shock 90 kD protein 1 alpha | ↑ 2,3 | defense system | X15183 |
| COL1A1 | collagen 1 alpha-1 | ↑ 2,2 | extracellular matrix | NM_000088 |
| MAX | MAX protein | ↑ 2,2 | cell cycle | NM_002382 |
| CTGF | connective tissue growth factor | ↑ 2,1 | cell cycle | U14750 |
| PCNA | proliferating cell nuclear antigen | ↑ 2,1 | control of DNA replication | NM002592 |
| TPA | plasminogen activator tissue | ↑ 2,1 | extracellular matrix | NM_000930 |
| CCND-1 | cyclin D1 | ↑ 2,1 | cell cycle | NM_053056 |
| MMP-1 | matrix metalloproteinase 1 | ↑ 2,1 | degradation of extracellular matrix | NM_002421 |
| MT2A | metallothionein 2A | ↑ 2 | defense system | V00594 |
| APO J | apolipoprotein J | ↑ 2 | defense system | J02908 |
| COL3A1 | collagen 3 alpha-1 | ↑ 2 | extracellular matrix | NM_000090 |
| HSP40 | heat shock 40 kD protein 1 | ↑ 2 | defense system | D49547 |
| MEK-1 | mitogen activated protein kinase kinase 1 | ↑ 2 | cell cycle | L11284 |
| p21 | cyclin dependent kinase inhibitor 1A | ↑ 1,9 | cell cycle | U03106 |
| NRG-1 | neuregulin | ↑ 1,9 | cell cycle | M94165 |
| FN1 | fibronectin | ↑ 1,9 | extracellular matrix | X02761 |
| TGFβRII | transforming growth factor-beta receptor II | ↑ 1,9 | growth factor | D50685 |
| Il-11 | interleukin 11 | ↑ 1,8 | cytokine | NM_000641 |
| MMP-2 | matrix metalloproteinase 2 | ↑ 1,8 | degradation of extracellular matrix | NM_004530 |
| ANX-1 | annexin 1 | ↑ 1,8 | anti-inflammatory | NM_000700 |
| HSP70B | heat shock 70 kD protein 6 | ↑ 1,8 | defense system | NM_002155 |
| IGF-BP5 | insulin growth factor binding protein 5 | ↑ 1,8 | growth factor | M65062 |
| JNK-2 | mitogen activated protein kinase 9 | ↑ 1,8 | defense system | U09759 |
| CANX | calnexin | ↑ 1,8 | cell cycle | NM_001746 |
| HSP27 | heat shock 27 kD protein 1 | ↑ 1,8 | defense system | AB020027 |
| EF1A | eucaryotic translation elongation factor-alpha | ↑ 1,7 | protein synthesis | AY043301 |
| PRX VI | peroxiredoxin VI | ↑ 1,7 | defense system | NM_004905 |
| MDM2 | MDM2 | ↑ 1,7 | cell cycle | NM_002392 |
| GPX | glutathion peroxidase | ↑ 1,6 | defense system | M21304 |
| H2BS | histone 2B member B/S consensus | ↑ 1,6 | cell cycle | NM_080593 |
| CCNH | cyclin H | ↑ 1,6 | cell cycle | NM_001239 |
| FMOD | fibromodulin | ↓ 0,6 | extracellular matrix | NM_002023 |
| ICAM-1 | intracellular adhesion molecule 1 | ↓ 0,3 | extracellular matrix | J031032 |
Total mRNA was collected at 72 hours after a series of 10 UVB stresses at 250 mJ/cm2.