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Table 1.

Quantification of neural plate size, mitosis and nuclear shape in wild-type and lulu embryos

Total neural cellsMitotic index (%)Ectopic pH3+ nuclei (%)Average L/W ratio
Wild type 25,315 5.35 (390/7295) 5.45 (27/495) 2.33±0.45 (n=100) 
lulu 23,205 5.32 (373/7013) 19.92 (47/236) 1.44±0.29 (n=78) 
Total neural cellsMitotic index (%)Ectopic pH3+ nuclei (%)Average L/W ratio
Wild type 25,315 5.35 (390/7295) 5.45 (27/495) 2.33±0.45 (n=100) 
lulu 23,205 5.32 (373/7013) 19.92 (47/236) 1.44±0.29 (n=78) 

Total anterior neural cells at E8.5 were counted and averaged for two wild-type and three lulu mutant embryos. The mitotic index[phospho-histone-H3-positive (pH3+) nuclei/total nuclei] was unchanged in lulu mutants. However, there was a 3.6-fold increase in ectopic mitotic nuclei in lulu embryos. Nuclear length:width (L/W)ratio was defined as the longest axis of the nucleus (L) divided by the orthogonal axis (W). ±, 1 standard deviation.

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