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Table 1.

Hemizygosity for a cnir deficiency causes specific synthetic lethality in cni mutant flies

(A) Df(2L)JS7 b cni^AR55 pr cn/SM6a × b cni^AA12 pr cn bw/CyO

Genotype scored

N (mut)

N (total)

P (mut)

P (expected)

Df(2L)JS7 b cni^AR55 pr cn/b cni^AA12 pr cn bw

246

0.01

0.33

(B) Df(2L)JS7 b cni^AR55 pr cn/SM6a × b cni^AR55 pr cn bw/CyO

Df(2L)JS7 b cni^AR55 pr cn/b cni^AR55 pr cn bw

193

0.33

Df(2L)JS7 b cni^AR55 pr cn/b cni^AR55 pr cn bw;pcni::Cnir/+

117

386

0.30

0.33

N (mut), observed number of hatching flies mutant for cni and hemizygous for the tested deficiency; N (total), total number of hatching flies; P (mut), observed frequency of flies mutant for cniand hemizygous for the tested deficiency; P (expected), expected frequency of flies mutant for cni and hemizygous for the tested deficiency under the assumption that there is no synthetic lethality (A and B)or that the rescue construct is fully functional (C).

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