Table 1.

Hemizygosity for a cnir deficiency causes specific synthetic lethality in cni mutant flies

(A) Df(2L)JS7 b cniAR55 pr cn/SM6a × b cniAA12 pr cn bw/CyO     
Genotype scored N (mut) N (total) P (mut) P (expected) 
Df(2L)JS7 b cniAR55 pr cn/b cniAA12 pr cn bw 246 0.01 0.33 
(B) Df(2L)JS7 b cniAR55 pr cn/SM6a × b cniAR55 pr cn bw/CyO     
Df(2L)JS7 b cniAR55 pr cn/b cniAR55 pr cn bw 193 0.33 
(C) Df(2L)JS7 b cniAR55 pr cn/SM6a × b cniAR55 pr cn bw/CyO; pcni::Cnir/pcni::Cnir     
Df(2L)JS7 b cniAR55 pr cn/b cniAR55 pr cn bw;pcni::Cnir/+ 117 386 0.30 0.33 
(A) Df(2L)JS7 b cniAR55 pr cn/SM6a × b cniAA12 pr cn bw/CyO     
Genotype scored N (mut) N (total) P (mut) P (expected) 
Df(2L)JS7 b cniAR55 pr cn/b cniAA12 pr cn bw 246 0.01 0.33 
(B) Df(2L)JS7 b cniAR55 pr cn/SM6a × b cniAR55 pr cn bw/CyO     
Df(2L)JS7 b cniAR55 pr cn/b cniAR55 pr cn bw 193 0.33 
(C) Df(2L)JS7 b cniAR55 pr cn/SM6a × b cniAR55 pr cn bw/CyO; pcni::Cnir/pcni::Cnir     
Df(2L)JS7 b cniAR55 pr cn/b cniAR55 pr cn bw;pcni::Cnir/+ 117 386 0.30 0.33 

N (mut), observed number of hatching flies mutant for cni and hemizygous for the tested deficiency; N (total), total number of hatching flies; P (mut), observed frequency of flies mutant for cniand hemizygous for the tested deficiency; P (expected), expected frequency of flies mutant for cni and hemizygous for the tested deficiency under the assumption that there is no synthetic lethality (A and B)or that the rescue construct is fully functional (C).

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