Effect of signaling pathways on L-mutant phenotype of ventral eye loss
| . | Genotype . | Strong suppression (%) . | Strong enhancement (%) . |
|---|---|---|---|
| Control | L2/+ | 0 (0/1000+) | 0 (0/1000+) |
| Cell-death genes | L2/+;ey>P35 | 40 (33/82) | |
| L2/+;ey>diap1 | 27 (12/44) | ||
| L2/+;H99/+ | 38 (21/55) | ||
| Wg pathway | L2/+;ey>wg | 92 (23/25) | |
| L2/+;ey>arm | 74 (29/36) | ||
| L2/+;ey>dsh | 70 (31/44) | ||
| L2/+;ey>SggS9A | 26 (9/35) | ||
| L2/+;ey>dTCFDN | 23 (7/34) | ||
| L2,wg1/+ | 35 (19/54) | ||
| JNK pathway | L2/+;ey>puc | 36 (20/56) | |
| hepr75/+;L2/+ | 32 (23/73) | ||
| L2/+;ey>bskDN | 34 (21/62) | ||
| L2/+;ey>bskAct | 39 (26/67) | ||
| L2/+;ey>Jun | 36 (19/53) | ||
| L2/+;ey>puc+P35 | 69 (49/71) |
| . | Genotype . | Strong suppression (%) . | Strong enhancement (%) . |
|---|---|---|---|
| Control | L2/+ | 0 (0/1000+) | 0 (0/1000+) |
| Cell-death genes | L2/+;ey>P35 | 40 (33/82) | |
| L2/+;ey>diap1 | 27 (12/44) | ||
| L2/+;H99/+ | 38 (21/55) | ||
| Wg pathway | L2/+;ey>wg | 92 (23/25) | |
| L2/+;ey>arm | 74 (29/36) | ||
| L2/+;ey>dsh | 70 (31/44) | ||
| L2/+;ey>SggS9A | 26 (9/35) | ||
| L2/+;ey>dTCFDN | 23 (7/34) | ||
| L2,wg1/+ | 35 (19/54) | ||
| JNK pathway | L2/+;ey>puc | 36 (20/56) | |
| hepr75/+;L2/+ | 32 (23/73) | ||
| L2/+;ey>bskDN | 34 (21/62) | ||
| L2/+;ey>bskAct | 39 (26/67) | ||
| L2/+;ey>Jun | 36 (19/53) | ||
| L2/+;ey>puc+P35 | 69 (49/71) |
In these genetic tests, the flies showing strong suppression (75-100% of wild-type eye size) or enhancement (0-25% of wild-type eye size) could be easily scored. The majority of the remaining flies also showed a range of mild suppression (or enhancement), but some weak phenotypes were too subtle to categorize. To avoid subjective characterization of these phenotypes, only the strong phenotypes were scored for a minimum estimate of genetic interactions.