Table 1.

Results of microarray analysis for Hr−/−versus wild-type skin

Gene name (GenBank Accession Number)Fold difference (knockout/wild type)
MicroarrayNorthernP
Caspase 14 (AF092997) 7.5 11.8 0 
Filaggrin (J03458) 4.9 5.7 0 
Neuropsin (D30785) 2.5 4.8 0 
Loricrin (U09189) 2.0 2.5 0 
Histidine ammonia lyase (L07645) 2.0 ND 0 
EST (AI854331) 2.0 ND 0 
Major urinary group gene (M17818) 4.9 6.8 1×10−6 
EST (AI836406) 2.5 ND 1×10−6 
Nuclear ribonuc. C1/C2 (AF095257) 2.5 ND 1×10−6 
Calmodulin 4/SCARF (AI119347) 2.3 2.5 1×10−6 
Connexin 43 (M63801) 2.1 1.2 1×10−6 
SAM decarboxylase (D12780) 2.1 1.3 1×10−6 
EST (AI843448) 0.5 1.1 1×10−6 
Keratin 10 (V00830) 2.1 2.0 6×10−6 
Kdap (AA726579) 2.0 2.0 7×10−6 
Gene name (GenBank Accession Number)Fold difference (knockout/wild type)
MicroarrayNorthernP
Caspase 14 (AF092997) 7.5 11.8 0 
Filaggrin (J03458) 4.9 5.7 0 
Neuropsin (D30785) 2.5 4.8 0 
Loricrin (U09189) 2.0 2.5 0 
Histidine ammonia lyase (L07645) 2.0 ND 0 
EST (AI854331) 2.0 ND 0 
Major urinary group gene (M17818) 4.9 6.8 1×10−6 
EST (AI836406) 2.5 ND 1×10−6 
Nuclear ribonuc. C1/C2 (AF095257) 2.5 ND 1×10−6 
Calmodulin 4/SCARF (AI119347) 2.3 2.5 1×10−6 
Connexin 43 (M63801) 2.1 1.2 1×10−6 
SAM decarboxylase (D12780) 2.1 1.3 1×10−6 
EST (AI843448) 0.5 1.1 1×10−6 
Keratin 10 (V00830) 2.1 2.0 6×10−6 
Kdap (AA726579) 2.0 2.0 7×10−6 

Fold difference is expression value for Hr−/− divided by value for wild type. Northern analysis was quantitated by phosphorimager and values normalized toβ-tubulin expression. P value indicates statistical significance of microarray data.

Kdap, keratinocyte differentiation associated protein; EST,expressed sequence tag (gene unknown); SAM, S-adenosylmethionine; ND, not determined.

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