The SLC12 family of electroneutral cation-coupled Cl– co-transporters
| Member* . | Co-transport ions . | Tissue distribution . | Disease . |
|---|---|---|---|
| SLC12A1 (NKCC2) | Na+/K+/2Cl- | Kidney-specific (TAL) | Bartter's syndrome type I |
| SLC12A2 (NKCC1) | Na+/K+/2Cl- | Ubiquitous | None |
| SLC12A3 (NCC) | Na+/Cl- | Kidney-specific (DCT); bone? | Gitelman's syndrome |
| SLC12A4 (KCC1) | K+/Cl- | Ubiquitous | None |
| SLC12A5 (KCC2) | K+/Cl- | Neuron-specific | None |
| SLC12A6 (KCC3) | K+/Cl- | Widespread | Anderman's syndrome |
| SLC12A7 (KCC4) | K+/Cl- | Widespread | None |
| SLC12A8 (CCC9) | Unknown | Widespread | Psoriasis |
| SLC12A9 (CIP) | Unknown | Widespread | None |
| Member* . | Co-transport ions . | Tissue distribution . | Disease . |
|---|---|---|---|
| SLC12A1 (NKCC2) | Na+/K+/2Cl- | Kidney-specific (TAL) | Bartter's syndrome type I |
| SLC12A2 (NKCC1) | Na+/K+/2Cl- | Ubiquitous | None |
| SLC12A3 (NCC) | Na+/Cl- | Kidney-specific (DCT); bone? | Gitelman's syndrome |
| SLC12A4 (KCC1) | K+/Cl- | Ubiquitous | None |
| SLC12A5 (KCC2) | K+/Cl- | Neuron-specific | None |
| SLC12A6 (KCC3) | K+/Cl- | Widespread | Anderman's syndrome |
| SLC12A7 (KCC4) | K+/Cl- | Widespread | None |
| SLC12A8 (CCC9) | Unknown | Widespread | Psoriasis |
| SLC12A9 (CIP) | Unknown | Widespread | None |
Names in parentheses indicate the protein symbol.