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Table 1.

Regeneration response of fetal digit tips

GenotypeExperimentTotal amputatedRegenerates% Regeneration
Wild type and Msx1+/- Organ culture 77 70 90.9 
Msx1-/- Organ culture 36 10 27.8 
Msx2-/- Organ culture 21 17 81.0 
Wild type and Msx2+/- Organ culture 50 43 86.0 
Wild type and Msx1+/- exo utero (in vivo) 33 28 88.9 
Msx1-/- exo utero (in vivo) 8 3 37.5 
Msx1-/- BMP4 (200 ng/ml) 15 11 73.0 
Msx1-/- BMP4 (1000 ng/ml) 21 18 86.0 
Msx1-/- BMP2 (200 ng/ml) 18 5 27.8 
Msx1-/- Noggin (200 ng/ml) 23 2 8.7 
Wild type and Msx1+/- Noggin (200 ng/ml) 82 15 18.3 
GenotypeExperimentTotal amputatedRegenerates% Regeneration
Wild type and Msx1+/- Organ culture 77 70 90.9 
Msx1-/- Organ culture 36 10 27.8 
Msx2-/- Organ culture 21 17 81.0 
Wild type and Msx2+/- Organ culture 50 43 86.0 
Wild type and Msx1+/- exo utero (in vivo) 33 28 88.9 
Msx1-/- exo utero (in vivo) 8 3 37.5 
Msx1-/- BMP4 (200 ng/ml) 15 11 73.0 
Msx1-/- BMP4 (1000 ng/ml) 21 18 86.0 
Msx1-/- BMP2 (200 ng/ml) 18 5 27.8 
Msx1-/- Noggin (200 ng/ml) 23 2 8.7 
Wild type and Msx1+/- Noggin (200 ng/ml) 82 15 18.3 
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