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Table 2.

Correlation between somitic Fgf10 expression and mammary development

Development of mammary placodes
GenotypeFgf10 expression in somitic subdomainsHistology of mammary line at E11.5 (±45 seconds)12345
Wild type Entire somites 11-18, high hypaxial and epaxial expression Cylindrical s.g., cylindrical s.i., covered with periderm 
Pax3ILZ/ILZ No hypaxial and epaxial expression, normal central expression in somites 11-18 Cylindrical s.g., reduced cylindrical s.i., covered with periderm Late 
Fgf10–/– None Cuboidal s.g., no s.i., periderm impaired – – – – 
Fgfr2b–/– As wild type (absent receptor for somitic FGFf10) As Fgf10–/– – – – – 
Gli3Xt-J/Xt-J Only hypaxial somites 11-16, low expression levels Cylindrical s.g., no s.i., covered with periderm – – 
Fgf10hypomorph Pattern as in wild type, but lower expression levels As Gil3Xt-J/Xt-J – 
Development of mammary placodes
GenotypeFgf10 expression in somitic subdomainsHistology of mammary line at E11.5 (±45 seconds)12345
Wild type Entire somites 11-18, high hypaxial and epaxial expression Cylindrical s.g., cylindrical s.i., covered with periderm 
Pax3ILZ/ILZ No hypaxial and epaxial expression, normal central expression in somites 11-18 Cylindrical s.g., reduced cylindrical s.i., covered with periderm Late 
Fgf10–/– None Cuboidal s.g., no s.i., periderm impaired – – – – 
Fgfr2b–/– As wild type (absent receptor for somitic FGFf10) As Fgf10–/– – – – – 
Gli3Xt-J/Xt-J Only hypaxial somites 11-16, low expression levels Cylindrical s.g., no s.i., covered with periderm – – 
Fgf10hypomorph Pattern as in wild type, but lower expression levels As Gil3Xt-J/Xt-J – 

For each mutant used in this study (column 1), the Fgf10expression pattern in the somites (column 2) and the histology of the mammary line at around E11.5 (column 3) are described. The formation (+) or the absence (–) of each of the five placode pairs is also indicated (columns 4-8)

Abbreviations: s.g., stratum germinativum; s.i., stratum intermedium

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