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Table 1.

Recombinant FGF10 rescues placode formation in vitro

Genotype and treatment
Number of glandsControlControl + BSAControl + Fgf10Fgf10–/– + BSAFgf10–/– + Fgf10Gli3Xt-JIXt-JGli3Xt-JIXt-J + BSAGli3Xt-JIXt-J + Fgf10
27 10 
7* 
1* 
Total number of explants: 104         
Genotype and treatment
Number of glandsControlControl + BSAControl + Fgf10Fgf10–/– + BSAFgf10–/– + Fgf10Gli3Xt-JIXt-JGli3Xt-JIXt-J + BSAGli3Xt-JIXt-J + Fgf10
27 10 
7* 
1* 
Total number of explants: 104         

Row 1 lists the genotypes of the flanks cultured with either no bead implanted, or with a bead soaked in BSA or rFGF10. Column 1 lists the total number of developing glands in these flanks as observed by Wnt10b or TOPGAL expression. The body of the table lists the number of flanks in which gland formation was analyzed

*

rFGF10 induced a supernumerary rudiment in ∼30% (7/23) of Fgf10–/– flanks and 9% (1/11) of Gli3Xt-JIXt-J flanks, but never in flanks of control embryos

Abbreviations: n.d., not determined; rFGF10, recombinant FGF10

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