Mouse line/genotype . | Pimary fiber/secondary fiber . | Lens clarity/morphology/size . |
---|---|---|
L1 heterozygous/α8S50P/+ α3+/+ | Elongation inhibition/disruption | Whole cataract/posterior rupture/very small |
L1 homozygous/α8S50P/S50P α3+/+ | Normal elongation/disruption | Whole cataract/posterior rupture/very small |
L1 heter w/o α3/α8S50P/+α3–/– | Elongation inhibition/normal | Nuclear cataract/no rupture/small |
L1 heter w/o α8/α8S50P/–α3+/+ | Normal elongation/disruption | Whole cataract/posterior rupture/very small |
L1 heter w/o α3 & α8/α8S50P/–α3–/– | Normal elongation/normal* | Large nuclear cataract/no rupture/small |
Mouse line/genotype . | Pimary fiber/secondary fiber . | Lens clarity/morphology/size . |
---|---|---|
L1 heterozygous/α8S50P/+ α3+/+ | Elongation inhibition/disruption | Whole cataract/posterior rupture/very small |
L1 homozygous/α8S50P/S50P α3+/+ | Normal elongation/disruption | Whole cataract/posterior rupture/very small |
L1 heter w/o α3/α8S50P/+α3–/– | Elongation inhibition/normal | Nuclear cataract/no rupture/small |
L1 heter w/o α8/α8S50P/–α3+/+ | Normal elongation/disruption | Whole cataract/posterior rupture/very small |
L1 heter w/o α3 & α8/α8S50P/–α3–/– | Normal elongation/normal* | Large nuclear cataract/no rupture/small |
Like double homozygous knockout α8–/–α3–/– lenses, α8S50P/–α3–/– lenses display normal peripheral secondary fiber cells, but inner mature fiber cells undergo degeneration to form a large nuclear cataract