Parameter . | Wild type (n=8) . | Tbx20lacZ/+ (n=7) . | Nkx2-5GFP/+ (n=6) . | Tbx20lacZ/+/Nkx2-5GFP/+ (n=7) . | Pvalue* . |
---|---|---|---|---|---|
BW† (g) | 28.9±2.4 | 28.0±1.4 | 28.1±3.0 | 27.3±1.4 | NS |
HW (g) | 0.16±0.03 | 0.15±0.02 | 0.15±0.03 | 0.16±0.03 | NS |
HW/BW | 5.39±0.93 | 5.52±0.81 | 5.29±0.27 | 6.07±0.93 | NS |
LVWT (mm) | 0.63±0.08 | 0.41±0.07‡ | 0.55±0.07‡,§ | 0.38±0.06‡,** | <0.001 |
LVDD (mm) | 3.43±0.08 | 3.68±0.15‡ | 3.57±0.26 | 3.67±0.18‡ | 0.027 |
LVSD (mm) | 1.35±0.05 | 1.92±0.31‡ | 1.71±0.38‡ | 1.98±0.36‡ | 0.001 |
LVFS (%) | 61±1 | 48±6‡ | 53±8‡ | 46±8‡ | <0.001 |
LAD (mm) | 1.61±0.04 | 1.87±0.10‡ | 1.74±0.11‡,§ | 2.10±0.19‡,§,¶,** | <0.001 |
HR (bpm) | 624±26 | 646±20 | 658±30‡ | 604±79 | NS |
Parameter . | Wild type (n=8) . | Tbx20lacZ/+ (n=7) . | Nkx2-5GFP/+ (n=6) . | Tbx20lacZ/+/Nkx2-5GFP/+ (n=7) . | Pvalue* . |
---|---|---|---|---|---|
BW† (g) | 28.9±2.4 | 28.0±1.4 | 28.1±3.0 | 27.3±1.4 | NS |
HW (g) | 0.16±0.03 | 0.15±0.02 | 0.15±0.03 | 0.16±0.03 | NS |
HW/BW | 5.39±0.93 | 5.52±0.81 | 5.29±0.27 | 6.07±0.93 | NS |
LVWT (mm) | 0.63±0.08 | 0.41±0.07‡ | 0.55±0.07‡,§ | 0.38±0.06‡,** | <0.001 |
LVDD (mm) | 3.43±0.08 | 3.68±0.15‡ | 3.57±0.26 | 3.67±0.18‡ | 0.027 |
LVSD (mm) | 1.35±0.05 | 1.92±0.31‡ | 1.71±0.38‡ | 1.98±0.36‡ | 0.001 |
LVFS (%) | 61±1 | 48±6‡ | 53±8‡ | 46±8‡ | <0.001 |
LAD (mm) | 1.61±0.04 | 1.87±0.10‡ | 1.74±0.11‡,§ | 2.10±0.19‡,§,¶,** | <0.001 |
HR (bpm) | 624±26 | 646±20 | 658±30‡ | 604±79 | NS |
BW, body weight; HW, heart weight; LV, left ventricle; WT, wall thickness;DD, end-diastolic diameter; SD, end-systolic diameter; FS, fractional shortening (determined as LVDD-LVSD/LVDD); LAD, left atrial diameter; HR,heart rate; NS, not significant.
P value determined by ANOVA
Mice aged 12-18 weeks
P<0.05 compared with wild type
P<0.05 Tbx20lacZ/+ compared with Nkx2-5GFP/+
P<0.05 Tbx20lacZ/+ compared with Tbx20lacZ/+/Nkx2-5GFP/+
P<0.05 Nkx2-5GFP/+ compared with Tbx20lacZ/+/Nkx2-5GFP/+