The Company of Biologists

Table 1.

Atrial septal dysmorphogenesis in adult mice

Genotype	n	Normal (%)	PFO (%)	ASA (%)	PFO + ASA (%)	ASD (%)
Wild type	21	18 (85.7)	3 (14.3)	0 (0)	0 (0)	0 (0)
Tbx20^lacZ/+	20	9 (45)	6 (30)	1 (5)	4 (20)	0 (0)
Nkx2-5^GFP/+	24	2 (8.3)	12 (50)	1 (4.2)	9 (37.5)	0 (0)
Tbx20^lacZ/+/Nkx2-5^GFP/+	24	3 (12.5)	4 (16.6)	1 (4.2)	12 (50)^{^*}	4 (16.7)^{^†}

Genotype	n	Normal (%)	PFO (%)	ASA (%)	PFO + ASA (%)	ASD (%)
Wild type	21	18 (85.7)	3 (14.3)	0 (0)	0 (0)	0 (0)
Tbx20^lacZ/+	20	9 (45)	6 (30)	1 (5)	4 (20)	0 (0)
Nkx2-5^GFP/+	24	2 (8.3)	12 (50)	1 (4.2)	9 (37.5)	0 (0)
Tbx20^lacZ/+/Nkx2-5^GFP/+	24	3 (12.5)	4 (16.6)	1 (4.2)	12 (50)^{^*}	4 (16.7)^{^†}

PFO, patent foramen ovale; ASA, atrial septal aneurysm; ASD, atrial septal defect.

Increase compared with PFO+ASA in Nkx2-5^GFP/+ not significant

P<0.05 compared with all other genotypes