Integrin chains that mediate phagocytosis
| Integrin . | Ligand . | Cell type . | Function . | References . | ||||
|---|---|---|---|---|---|---|---|---|
| Physiological phagocytosis in mammals | ||||||||
| αMβ2 | C3bi, fibrinogen | Phagocytes | Innate immunity | (Beller et al., 1982) | ||||
| αVβ3, αVβ5 | MFG-E8 | Phagocytes | Clearance of apoptotic cells | (Hanayama et al., 2002; Savill et al., 1990) | ||||
| αVβ5 | MFG-E8 | RPE | Circadian rhythm of RPE | (Finnemann et al., 1997; Nandrot et al., 2007) | ||||
| α2β1 | Collagen | Fibroblasts | ECM remodelling | (Arora et al., 2000; Lee et al., 1996) | ||||
| α6β1* | fAβ peptide | Phagocytes | Removal of fAβ deposits | (Koenigsknecht and Landreth, 2004) | ||||
| Pathological phagocytosis-like process in mammals | ||||||||
| β1 | Yersinia spp. invasin | Epithelial cells | Yersinia spp. entry | (Tran Van Nhieu and Isberg, 1993) | ||||
| α5β1 | Fibronectin | Many† | S. aureus entry | (Fowler et al., 2000; Sinha et al., 1999) | ||||
| α5β1, αVβ3? | Glycoproteins | Many† | Herpes virus entry | (Akula et al., 2002; Garrigues et al., 2008) | ||||
| αVβ3, αVβ5 | Capside protein | Epithelial cells | Adenovirus entry | (Li et al., 1998; Wickham et al., 1993) | ||||
| Physiological phagocytosis in insects | ||||||||
| A. gambia | ||||||||
| BIMP2 | Unknown | Haemocyte | Immunity | (Moita et al., 2006; Moita et al., 2005) | ||||
| D. melanogaster | ||||||||
| hβ3-like | Unknown | Haemocyte | Immunity | (Foukas et al., 1998) | ||||
| Integrin . | Ligand . | Cell type . | Function . | References . | ||||
|---|---|---|---|---|---|---|---|---|
| Physiological phagocytosis in mammals | ||||||||
| αMβ2 | C3bi, fibrinogen | Phagocytes | Innate immunity | (Beller et al., 1982) | ||||
| αVβ3, αVβ5 | MFG-E8 | Phagocytes | Clearance of apoptotic cells | (Hanayama et al., 2002; Savill et al., 1990) | ||||
| αVβ5 | MFG-E8 | RPE | Circadian rhythm of RPE | (Finnemann et al., 1997; Nandrot et al., 2007) | ||||
| α2β1 | Collagen | Fibroblasts | ECM remodelling | (Arora et al., 2000; Lee et al., 1996) | ||||
| α6β1* | fAβ peptide | Phagocytes | Removal of fAβ deposits | (Koenigsknecht and Landreth, 2004) | ||||
| Pathological phagocytosis-like process in mammals | ||||||||
| β1 | Yersinia spp. invasin | Epithelial cells | Yersinia spp. entry | (Tran Van Nhieu and Isberg, 1993) | ||||
| α5β1 | Fibronectin | Many† | S. aureus entry | (Fowler et al., 2000; Sinha et al., 1999) | ||||
| α5β1, αVβ3? | Glycoproteins | Many† | Herpes virus entry | (Akula et al., 2002; Garrigues et al., 2008) | ||||
| αVβ3, αVβ5 | Capside protein | Epithelial cells | Adenovirus entry | (Li et al., 1998; Wickham et al., 1993) | ||||
| Physiological phagocytosis in insects | ||||||||
| A. gambia | ||||||||
| BIMP2 | Unknown | Haemocyte | Immunity | (Moita et al., 2006; Moita et al., 2005) | ||||
| D. melanogaster | ||||||||
| hβ3-like | Unknown | Haemocyte | Immunity | (Foukas et al., 1998) | ||||
Several integrins have been involved in phagocytosis in metazoa. For each integrin, the ligand involved, the cell type that mediates uptake and the relevant biological function are indicated. The term phagocyte refers to cells that are classically associated with phagocytic uptake, i.e. neutrophils, macrophages, DCs and microglial cells in mammals. See text for details
Necessary but not sufficient
epithelial, endothelial, fibroblast