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Table 1.

Integrin chains that mediate phagocytosis

Integrin Ligand Cell type Function References
Physiological phagocytosis in mammals     
αMβ2   C3bi, fibrinogen   Phagocytes   Innate immunity   (Beller et al., 1982)  
αVβ3, αVβ5   MFG-E8   Phagocytes   Clearance of apoptotic cells   (Hanayama et al., 2002; Savill et al., 1990)  
αVβ5   MFG-E8   RPE   Circadian rhythm of RPE   (Finnemann et al., 1997; Nandrot et al., 2007)  
α2β1   Collagen   Fibroblasts   ECM remodelling   (Arora et al., 2000; Lee et al., 1996)  
α6β1*  fAβ peptide   Phagocytes   Removal of fAβ deposits   (Koenigsknecht and Landreth, 2004)  
Pathological phagocytosis-like process in mammals     
β1  Yersinia spp. invasin   Epithelial cells  Yersinia spp. entry   (Tran Van Nhieu and Isberg, 1993)  
α5β1   Fibronectin   Many S. aureus entry   (Fowler et al., 2000; Sinha et al., 1999)  
α5β1, αVβ3?   Glycoproteins   Many  Herpes virus entry   (Akula et al., 2002; Garrigues et al., 2008)  
αVβ3, αVβ5   Capside protein   Epithelial cells   Adenovirus entry   (Li et al., 1998; Wickham et al., 1993)  
Physiological phagocytosis in insects     
A. gambia     
BIMP2   Unknown   Haemocyte   Immunity   (Moita et al., 2006; Moita et al., 2005)  
D. melanogaster     
3-like   Unknown   Haemocyte   Immunity   (Foukas et al., 1998)  
Integrin Ligand Cell type Function References
Physiological phagocytosis in mammals     
αMβ2   C3bi, fibrinogen   Phagocytes   Innate immunity   (Beller et al., 1982)  
αVβ3, αVβ5   MFG-E8   Phagocytes   Clearance of apoptotic cells   (Hanayama et al., 2002; Savill et al., 1990)  
αVβ5   MFG-E8   RPE   Circadian rhythm of RPE   (Finnemann et al., 1997; Nandrot et al., 2007)  
α2β1   Collagen   Fibroblasts   ECM remodelling   (Arora et al., 2000; Lee et al., 1996)  
α6β1*  fAβ peptide   Phagocytes   Removal of fAβ deposits   (Koenigsknecht and Landreth, 2004)  
Pathological phagocytosis-like process in mammals     
β1  Yersinia spp. invasin   Epithelial cells  Yersinia spp. entry   (Tran Van Nhieu and Isberg, 1993)  
α5β1   Fibronectin   Many S. aureus entry   (Fowler et al., 2000; Sinha et al., 1999)  
α5β1, αVβ3?   Glycoproteins   Many  Herpes virus entry   (Akula et al., 2002; Garrigues et al., 2008)  
αVβ3, αVβ5   Capside protein   Epithelial cells   Adenovirus entry   (Li et al., 1998; Wickham et al., 1993)  
Physiological phagocytosis in insects     
A. gambia     
BIMP2   Unknown   Haemocyte   Immunity   (Moita et al., 2006; Moita et al., 2005)  
D. melanogaster     
3-like   Unknown   Haemocyte   Immunity   (Foukas et al., 1998)  

Several integrins have been involved in phagocytosis in metazoa. For each integrin, the ligand involved, the cell type that mediates uptake and the relevant biological function are indicated. The term phagocyte refers to cells that are classically associated with phagocytic uptake, i.e. neutrophils, macrophages, DCs and microglial cells in mammals. See text for details

*

Necessary but not sufficient

epithelial, endothelial, fibroblast

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