The Rab family
| Rab . | Localization . | Function . | References . | |||
|---|---|---|---|---|---|---|
| (1) Rab23 Rab23 | Plasma membrane and endosomes | Trafficking of sonic hedgehog signaling components; embryogenesis; ciliary trafficking | Evans et al., 2003 | |||
| (2) Rab29, Rab32, Rab38, Rab7L1 | ||||||
| Rab32 | Perinuclear vesicles; mitochondria | Post-Golgi trafficking of melanogenic enzymes; binds PKA and regulates mitochondrial dynamics | Alto et al., 2002; Wasmeier et al., 2006 | |||
| Rab38 | Tyrosinase-positive vesicles | Post-Golgi biogenesis of melanosomes | Wasmeier et al., 2006 | |||
| (3) RabL2, RabL3, RabL5 | ||||||
| (4) Ran | ||||||
| Ran | Nucleus, cytoplasm | Nucleocytoplasmic transport | Joseph, 2006 | |||
| (5) Rab7, Rab7b, Rab9 | ||||||
| Rab7, Rab7b | Late endosomes, lysosomes | Transport from early to late endosomes; lysosome biogenesis; b) transport to lysosomes, TLR4 signaling | Feng et al., 2001; Bucci et al., 2000; Wang et al., 2007 | |||
| Rab9a,b,c | Late endosomes | Lysosomal enzyme and cholesterol trafficking; late endosome to trans-Golgi transport | Ganley et al., 2004; Lombardi et al., 1993; Narita et al., 2005 | |||
| (6) Rab28, RabL4 | ||||||
| (7) Rab34, Rab36 | ||||||
| Rab34 | Cell surface membrane ruffles, lysosomes | Regulation of spatial distribution of lysosomes; Formation of macropinosomes | Colucci et al., 2005; Sun and Endo, 2005; Sun et al., 2003; Wu et al., 2005 | |||
| (8) Rab6, Rab41 | ||||||
| Rab6a,a′,b,c | (a,a′,b) Golgi, (b) ERGIC-53-positive vesicles and neuronal cell specific | Retrograde transport; (a,b) Golgi to ER and intra-Golgi tranport, Golgi stress response (a′) endosome to Golgi transport; (c) multi-drug resistance regulation | Jiang and Storrie, 2005; Martinez et al., 1994; Del Nery et al., 2006; Opdam et al., 2000; Shan et al., 2000 | |||
| (9) Rab5, Rab17, Rab20, Rab21, Rab22a/Rab31, Rab24 | ||||||
| Rab5a,b,c | Clathrin coated vesicles, caveosomes, and early endosomes. | Endocytosis, early endosome fusion, caveolar vesicle targeting to early endosomes; (a) EGF receptor activation; (b) neuroprotection | Pelkmans et al., 2004; Barbieri et al., 2000; Arnett et al., 2004; Bucci et al., 1995 | |||
| Rab17 | Epithelial specific; apical recycling endosome | Transport through apical recycling endosomes; polarized sorting | Zacchi et al., 1998 | |||
| Rab20 | Epithelial specific; kidney dense apical tubules | V-ATPase trafficking | Curtis and Gluck, 2005 | |||
| Rab21 | Early endosomes | Endocytosis of integrins, cell-extracellular matrix adhesion and motility | Pellinen et al., 2006 | |||
| Rab22a,b,c/Rab31 | Early endosomes and trans-Golgi | Biosynthetic pathway; (a) endosome to Golgi transport; phagosome maturation (b) trans-Golgi to endosome transport | Kauppi et al., 2002; Mesa et al., 2001; Roberts et al., 2006; Rodriguez-Gabin et al., 2001 | |||
| Rab24 | Autophagosomes, nuclear inclusions | Induction of autophagy, tyrosine phosphorylated | Munafó and Colombo, 2002; Overmeyer and Maltese, 2005 | |||
| (10) Rab18 | ||||||
| Rab18 | Dense apical tubules (kidney) and basolateral membrane (intestine); ER/lipid droplets; neuroendocrine secretory granules | Formation of lipid droplets from ER; negative regulator of neuroendocrine secretion | Lütcke et al., 1994; Ozeki et al., 2005; Vazquez-Martinez et al., 2007 | |||
| (11) Rab2, Rab4, Rab11, Rab14, Rab25, Rab39, Rab42 | ||||||
| Rab2a,b | Endoplasmic reticulum | ER to Golgi transport | Tisdale et al., 1992 | |||
| Rab4a,b,c | Early and recycling endosomes | Rapid endocytic recycling to plasma membrane; (a) adherens junction disassembly | van der Sluijs et al., 1992; Mruk et al., 2007; Bottger et al., 1996 | |||
| Rab11a,b | (a) Golgi and recycling endosomes; (b) neuronal specific | (a) Transport from Golgi to apical endocytic recycling endosomes; phagocytosis in macrophages; (b) Ca2+-dependent secretion | Ullrich et al., 1996; Wilcke et al., 2000; Khvotchev et al., 2003 | |||
| Rab14 | Rough ER; Golgi/trans-Golgi and early endosomes | Phagosome and early endosome fusion; trafficking between early endosomes and Golgi | Junutula et al., 2004; Kyei et al., 2006; Proikas-Cezanne et al., 2006 | |||
| Rab25 | Epithelial specific; apical recycling endosome | Transport of apical recycling endosomes | Casanova et al., 1999; Wang et al., 2000 | |||
| (12) Rab19, Rab30, Rab33, Rab43 | ||||||
| Rab33a,b | Medial Golgi | Retrograde Golgi transport to ER | Valsdottir et al., 2001 | |||
| (13) Rab1, Rab3, Rab8, Rab10, Rab12, Rab13, Rab15, Rab40 | ||||||
| Rab1a,b | Endoplasmic reticulum | ER to Golgi transport | Tisdale et al., 1992; Allan et al., 2000 | |||
| Rab3a,b,c,d | Synaptic and secretory vesicles. | Regulated exocytosis; (a-d) Ca2+-dependent secretion and vesicle docking; dense-core vesicle docking to the plasma membrane (with Rab27) | Rupnik et al., 2007; Schlüter et al., 2002; Tsuboi and Fukuda, 2006 | |||
| Rab8a,b | Golgi region, endosomes, dendrites, basolateral plasma membrane | Trafficking between Golgi, endosomes and plasma membrane; cholesterol degradation; Extension of primary ciliary membrane (a) basolateral transport in epithelia and dendritic transport in neurons; (b) adherens junction assembly | Nachury et al., 2007; Peränen et al., 1996; Chen et al., 2001; Chen and Wandinger-Ness, 2001; Hattula et al., 2006; Linder et al., 2007 | |||
| Rab10 | Golgi | Polarized membrane transport from Golgi to basolateral membrane, may co-operate with Rab8 | Babbey et al., 2006; Chen et al., 1993; Schuck et al., 2007 | |||
| Rab12 | Centrosomes | Transport from cell periphery to perinuclear centrosomes | Iida et al., 2005 | |||
| Rab13 | Tight junctions and endosomes | Tight junction biogenesis | Marzesco et al., 2002 | |||
| Rab15 | Early/sorting and recycling endosomes | Trafficking through recycling endosomes; coordinates rapid and slow recycling; attenuates Rab5 function | Elferink and Strick, 2005; Zuk and Elferink, 2000 | |||
| (14) Rab26, Rab27, Rab37, Rab44, Rasef | ||||||
| Rab26 | Secretory granules | Regulated secretion of granules | Yoshie et al., 2000 | |||
| Rab27a,b | Epithelial specific; melanosomes | Exocytosis; (a) Transport of secretory granules, dense-core vesicles (with Rab3a) and lysosome-related organelles; myosin recruitment to melanosomes; (b) platelet specific, regulated secretion | Barral et al., 2002; Futter, 2006; Tolmachova et al., 2007; Tsuboi and Fukuda, 2006 | |||
| Rab37 | Secretory granules (insulin and mast cell granules) | Mast cell degranulation | Masuda et al., 2000; Brunner et al., 2007 | |||
| Rab . | Localization . | Function . | References . | |||
|---|---|---|---|---|---|---|
| (1) Rab23 Rab23 | Plasma membrane and endosomes | Trafficking of sonic hedgehog signaling components; embryogenesis; ciliary trafficking | Evans et al., 2003 | |||
| (2) Rab29, Rab32, Rab38, Rab7L1 | ||||||
| Rab32 | Perinuclear vesicles; mitochondria | Post-Golgi trafficking of melanogenic enzymes; binds PKA and regulates mitochondrial dynamics | Alto et al., 2002; Wasmeier et al., 2006 | |||
| Rab38 | Tyrosinase-positive vesicles | Post-Golgi biogenesis of melanosomes | Wasmeier et al., 2006 | |||
| (3) RabL2, RabL3, RabL5 | ||||||
| (4) Ran | ||||||
| Ran | Nucleus, cytoplasm | Nucleocytoplasmic transport | Joseph, 2006 | |||
| (5) Rab7, Rab7b, Rab9 | ||||||
| Rab7, Rab7b | Late endosomes, lysosomes | Transport from early to late endosomes; lysosome biogenesis; b) transport to lysosomes, TLR4 signaling | Feng et al., 2001; Bucci et al., 2000; Wang et al., 2007 | |||
| Rab9a,b,c | Late endosomes | Lysosomal enzyme and cholesterol trafficking; late endosome to trans-Golgi transport | Ganley et al., 2004; Lombardi et al., 1993; Narita et al., 2005 | |||
| (6) Rab28, RabL4 | ||||||
| (7) Rab34, Rab36 | ||||||
| Rab34 | Cell surface membrane ruffles, lysosomes | Regulation of spatial distribution of lysosomes; Formation of macropinosomes | Colucci et al., 2005; Sun and Endo, 2005; Sun et al., 2003; Wu et al., 2005 | |||
| (8) Rab6, Rab41 | ||||||
| Rab6a,a′,b,c | (a,a′,b) Golgi, (b) ERGIC-53-positive vesicles and neuronal cell specific | Retrograde transport; (a,b) Golgi to ER and intra-Golgi tranport, Golgi stress response (a′) endosome to Golgi transport; (c) multi-drug resistance regulation | Jiang and Storrie, 2005; Martinez et al., 1994; Del Nery et al., 2006; Opdam et al., 2000; Shan et al., 2000 | |||
| (9) Rab5, Rab17, Rab20, Rab21, Rab22a/Rab31, Rab24 | ||||||
| Rab5a,b,c | Clathrin coated vesicles, caveosomes, and early endosomes. | Endocytosis, early endosome fusion, caveolar vesicle targeting to early endosomes; (a) EGF receptor activation; (b) neuroprotection | Pelkmans et al., 2004; Barbieri et al., 2000; Arnett et al., 2004; Bucci et al., 1995 | |||
| Rab17 | Epithelial specific; apical recycling endosome | Transport through apical recycling endosomes; polarized sorting | Zacchi et al., 1998 | |||
| Rab20 | Epithelial specific; kidney dense apical tubules | V-ATPase trafficking | Curtis and Gluck, 2005 | |||
| Rab21 | Early endosomes | Endocytosis of integrins, cell-extracellular matrix adhesion and motility | Pellinen et al., 2006 | |||
| Rab22a,b,c/Rab31 | Early endosomes and trans-Golgi | Biosynthetic pathway; (a) endosome to Golgi transport; phagosome maturation (b) trans-Golgi to endosome transport | Kauppi et al., 2002; Mesa et al., 2001; Roberts et al., 2006; Rodriguez-Gabin et al., 2001 | |||
| Rab24 | Autophagosomes, nuclear inclusions | Induction of autophagy, tyrosine phosphorylated | Munafó and Colombo, 2002; Overmeyer and Maltese, 2005 | |||
| (10) Rab18 | ||||||
| Rab18 | Dense apical tubules (kidney) and basolateral membrane (intestine); ER/lipid droplets; neuroendocrine secretory granules | Formation of lipid droplets from ER; negative regulator of neuroendocrine secretion | Lütcke et al., 1994; Ozeki et al., 2005; Vazquez-Martinez et al., 2007 | |||
| (11) Rab2, Rab4, Rab11, Rab14, Rab25, Rab39, Rab42 | ||||||
| Rab2a,b | Endoplasmic reticulum | ER to Golgi transport | Tisdale et al., 1992 | |||
| Rab4a,b,c | Early and recycling endosomes | Rapid endocytic recycling to plasma membrane; (a) adherens junction disassembly | van der Sluijs et al., 1992; Mruk et al., 2007; Bottger et al., 1996 | |||
| Rab11a,b | (a) Golgi and recycling endosomes; (b) neuronal specific | (a) Transport from Golgi to apical endocytic recycling endosomes; phagocytosis in macrophages; (b) Ca2+-dependent secretion | Ullrich et al., 1996; Wilcke et al., 2000; Khvotchev et al., 2003 | |||
| Rab14 | Rough ER; Golgi/trans-Golgi and early endosomes | Phagosome and early endosome fusion; trafficking between early endosomes and Golgi | Junutula et al., 2004; Kyei et al., 2006; Proikas-Cezanne et al., 2006 | |||
| Rab25 | Epithelial specific; apical recycling endosome | Transport of apical recycling endosomes | Casanova et al., 1999; Wang et al., 2000 | |||
| (12) Rab19, Rab30, Rab33, Rab43 | ||||||
| Rab33a,b | Medial Golgi | Retrograde Golgi transport to ER | Valsdottir et al., 2001 | |||
| (13) Rab1, Rab3, Rab8, Rab10, Rab12, Rab13, Rab15, Rab40 | ||||||
| Rab1a,b | Endoplasmic reticulum | ER to Golgi transport | Tisdale et al., 1992; Allan et al., 2000 | |||
| Rab3a,b,c,d | Synaptic and secretory vesicles. | Regulated exocytosis; (a-d) Ca2+-dependent secretion and vesicle docking; dense-core vesicle docking to the plasma membrane (with Rab27) | Rupnik et al., 2007; Schlüter et al., 2002; Tsuboi and Fukuda, 2006 | |||
| Rab8a,b | Golgi region, endosomes, dendrites, basolateral plasma membrane | Trafficking between Golgi, endosomes and plasma membrane; cholesterol degradation; Extension of primary ciliary membrane (a) basolateral transport in epithelia and dendritic transport in neurons; (b) adherens junction assembly | Nachury et al., 2007; Peränen et al., 1996; Chen et al., 2001; Chen and Wandinger-Ness, 2001; Hattula et al., 2006; Linder et al., 2007 | |||
| Rab10 | Golgi | Polarized membrane transport from Golgi to basolateral membrane, may co-operate with Rab8 | Babbey et al., 2006; Chen et al., 1993; Schuck et al., 2007 | |||
| Rab12 | Centrosomes | Transport from cell periphery to perinuclear centrosomes | Iida et al., 2005 | |||
| Rab13 | Tight junctions and endosomes | Tight junction biogenesis | Marzesco et al., 2002 | |||
| Rab15 | Early/sorting and recycling endosomes | Trafficking through recycling endosomes; coordinates rapid and slow recycling; attenuates Rab5 function | Elferink and Strick, 2005; Zuk and Elferink, 2000 | |||
| (14) Rab26, Rab27, Rab37, Rab44, Rasef | ||||||
| Rab26 | Secretory granules | Regulated secretion of granules | Yoshie et al., 2000 | |||
| Rab27a,b | Epithelial specific; melanosomes | Exocytosis; (a) Transport of secretory granules, dense-core vesicles (with Rab3a) and lysosome-related organelles; myosin recruitment to melanosomes; (b) platelet specific, regulated secretion | Barral et al., 2002; Futter, 2006; Tolmachova et al., 2007; Tsuboi and Fukuda, 2006 | |||
| Rab37 | Secretory granules (insulin and mast cell granules) | Mast cell degranulation | Masuda et al., 2000; Brunner et al., 2007 | |||
Uncharacterized Rab family members are highlighted in red.