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Table 2.

Inhibition of the V-ATPase activity and cell growth by apicularen

Compound	V₁V_O holoenzyme Manduca sexta^aIC₅₀ (μmol l^–1)	Growth inhibition Murine cell line L-929^b IC₅₀ (μmol l^–1)
Apicularen A	0.02	0.005
Apicularen B	0.06	0.6
N-methyl-apicularen	0.2	0.8
11-deoxy-apicularen	0.02	0.02
Open apicularen	0.02	0.2
Oxime apicularen	0.2	2
Enyne apicularen	1	5

Compound	V₁V_O holoenzyme Manduca sexta^aIC₅₀ (μmol l^–1)	Growth inhibition Murine cell line L-929^b IC₅₀ (μmol l^–1)
Apicularen A	0.02	0.005
Apicularen B	0.06	0.6
N-methyl-apicularen	0.2	0.8
11-deoxy-apicularen	0.02	0.02
Open apicularen	0.02	0.2
Oxime apicularen	0.2	2
Enyne apicularen	1	5

Data taken from ^aHuss et al.(Huss et al., 2005), M.H., M. E. Maier and H.W. (unpublished observations), and ^bPetri et al.(Petri et al., 2005)