Inhibition of the V-ATPase activity and cell growth by archazolids
| Compound . | V1VO holoenzyme Manduca sexta IC50(μmol l–1) . | Growth inhibition murine cell line L-929 IC50 (μmol l–1) . |
|---|---|---|
| Archazolid A | 0.02 | 0.001 |
| Archazolid B | 0.02 | 0.001 |
| Archazolid C | 5 | 2 |
| Archazolid D | 15 | 0.3 |
| 15-dehydro-archazolid A | 0.3 | >5 |
| 1′-descarbamoyl-archazolid A | 0.1 | 0.01 |
| 7-O-p-Nitrobenzoate-archazolid A | 6 | 0.3 |
| 7-O-TBS-archazolid A | 4 | 0.9 |
| Compound . | V1VO holoenzyme Manduca sexta IC50(μmol l–1) . | Growth inhibition murine cell line L-929 IC50 (μmol l–1) . |
|---|---|---|
| Archazolid A | 0.02 | 0.001 |
| Archazolid B | 0.02 | 0.001 |
| Archazolid C | 5 | 2 |
| Archazolid D | 15 | 0.3 |
| 15-dehydro-archazolid A | 0.3 | >5 |
| 1′-descarbamoyl-archazolid A | 0.1 | 0.01 |
| 7-O-p-Nitrobenzoate-archazolid A | 6 | 0.3 |
| 7-O-TBS-archazolid A | 4 | 0.9 |
Data taken from Huss et al. (Huss et al., 2005) and Menche et al.(Menche et al., 2007a; Menche et al., 2007b; Menche et al., 2007c)