Table 7.

Effect of ethylisopropylamiloride (EIPA), ethoxzolamide (ETOX) and bafilomycin on unidirectional Na+ efflux and net flux in snails under un-bled and bled conditions

DrugCondition (N)Efflux (nmol g–1 h–1)Net flux (nmol g–1 h–1)
Control Un-bled (10) –559±30 –257±49 
 Bled (8) –136±23 505±58 
1% DMSO control Un-bled (10) –440±27 –249±35 
 Bled (10) –384±38 411±97 
EIPA Un-bled (5) –552±68 –424±62 
 Bled (10) –266±64 230±29§ 
ETOX Un-bled (10) –2534±195* –2057±209 
 Bled (10) –208±36 360±44 
Bafilomycin Un-bled (7) –890±147* –767±164 
 Bled (10) –125±57 256±40 
DrugCondition (N)Efflux (nmol g–1 h–1)Net flux (nmol g–1 h–1)
Control Un-bled (10) –559±30 –257±49 
 Bled (8) –136±23 505±58 
1% DMSO control Un-bled (10) –440±27 –249±35 
 Bled (10) –384±38 411±97 
EIPA Un-bled (5) –552±68 –424±62 
 Bled (10) –266±64 230±29§ 
ETOX Un-bled (10) –2534±195* –2057±209 
 Bled (10) –208±36 360±44 
Bafilomycin Un-bled (7) –890±147* –767±164 
 Bled (10) –125±57 256±40 

Values are presented as mean ± s.e.m.

*

Significantly greater unidirectional Na+ efflux compared with un-bled DMSO vehicle control

Significantly greater net Na+ loss compared with un-bled DMSO vehicle control

Significantly less unidirectional Na+ efflux compared with bled DMSO vehicle control

§

Significantly less net Na+ uptake compared with bled DMSO vehicle control

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