Brain fatty acid characterisation showing the distribution of saturated,monounsaturated, omega-3 and omega-6 polyunsaturated fatty acids plus the contribution to unsaturation index of the major fatty acids within each phospholipid classes
| Phospholipid . | Mouse . | Sheep . | Cow . |
|---|---|---|---|
| Phosphatidylcholine | |||
| ΣSFA | 61.9±3.9 | 58.4±0.9 | 57.4±2.2 |
| ΣMUFA | 27.5±2.0 | 33.9±1.1 | 36.2±3.2 |
| ΣPUFA n-6 | 6.2±0.4s,c | 4.1±0.2m | 3.8±0.2m |
| ΣPUFA n-3 | 4.5±0.4c | 3.6±0.2 | 2.6±0.6m |
| UI | 78.7±1.3s,c | 70.7±0.7m | 67.3±2.6m |
| UI (18:1 n-9) | 25.2±0.2s,c | 29.9±0.5m | 32.3±1.5m |
| UI (18:2 n-6) | 0.5±0.1s,c | 1.1±0.1m,c | 1.5±0.1m,s |
| UI (20:4 n-6) | 22.5±1.1s,c | 13.7±1.0m | 11.3±1.3m |
| UI (22:6 n-3) | 27.1±0.6s | 21.4±1.2m | 16.3±3.5 |
| Phosphatidylethanolamine | |||
| ΣSFA | 45.2±7.7 | 45.1±4.6 | 43.4±4.4 |
| ΣMUFA | 11.4±1.8 | 11.7±1.0 | 16.7±2.8 |
| ΣPUFA n-6 | 13.4±2.9 | 12.7±1.7 | 13.4±1.3 |
| ΣPUFA n-3 | 30.0±4.2 | 30.6±2.9 | 26.5±4.2 |
| UI | 246.1±1.8 | 247.1±1.1 | 230.0±7.9 |
| UI (18:1 n-9) | 11.0±0.3 | 11.5±0.2 | 16.0±2.2 |
| UI (18:2 n-6) | 0±0 | 0±0 | 0±0 |
| UI (20:4 n-6) | 41.9±1.9s | 34.1±2.1m | 34.7±3.2 |
| UI (22:6 n-3) | 187.0±3.9 | 184.6±4.4 | 158.0±13.6 |
| Phosphatidylserine | |||
| ΣSFA | 45.2±7.9 | 47.2±6.2 | 46.5±3.8 |
| ΣMUFA | 18.8±7.6 | 19.4±5.2 | 26.2±5.6 |
| ΣPUFA n-6 | 5.0±1.4 | 5.1±0.6 | 5.5±0.7 |
| ΣPUFA n-3 | 31.1±2.8 | 28.4±1.6 | 21.8±2.7 |
| UI | 230.9±12.0 | 211.3±11.6 | 178.2±19.7 |
| UI (18:1 n-9) | 16.9±3.2 | 17.5±2.3 | 24.1±3.8 |
| UI (18:2 n-6) | 0±0 | 0±0 | 0±0 |
| UI (20:4 n-6) | 16.1±0.9c | 13.5±1.8 | 12.1±1.3m |
| UI (22:6 n-3) | 196.0±11.2 | 175.3±13.3 | 135.0±24.0 |
| Phosphatidic acid | |||
| ΣSFA | 43.6±2.5 | 37.9±3.8 | 44.9±6.4 |
| ΣMUFA | 27.2±2.7 | 42.5±9.9 | 40.2±8.7 |
| ΣPUFA n-6 | 7.0±1.3 | 6.1±0.8 | 2.8±0.7 |
| ΣPUFA n-3 | 22.2±0.7 | 13.6±1.9 | 12.0±2.4 |
| UI | 188.7±2.2 | 150.9±10.9 | 130.3±19.9 |
| UI (18:1 n-9) | 27.0±1.0 | 41.1±4.4 | 39.0±4.4 |
| UI (18:2 n-6) | 0±0 | 0±0 | 0±0 |
| UI (20:4 n-6) | 27.5±3.3c | 26.3±5.8 | 10.7±1.4m |
| UI (22:6 n-3) | 134.2±5.9 | 83.4±10.8 | 80.6±24.4 |
| Phospholipid . | Mouse . | Sheep . | Cow . |
|---|---|---|---|
| Phosphatidylcholine | |||
| ΣSFA | 61.9±3.9 | 58.4±0.9 | 57.4±2.2 |
| ΣMUFA | 27.5±2.0 | 33.9±1.1 | 36.2±3.2 |
| ΣPUFA n-6 | 6.2±0.4s,c | 4.1±0.2m | 3.8±0.2m |
| ΣPUFA n-3 | 4.5±0.4c | 3.6±0.2 | 2.6±0.6m |
| UI | 78.7±1.3s,c | 70.7±0.7m | 67.3±2.6m |
| UI (18:1 n-9) | 25.2±0.2s,c | 29.9±0.5m | 32.3±1.5m |
| UI (18:2 n-6) | 0.5±0.1s,c | 1.1±0.1m,c | 1.5±0.1m,s |
| UI (20:4 n-6) | 22.5±1.1s,c | 13.7±1.0m | 11.3±1.3m |
| UI (22:6 n-3) | 27.1±0.6s | 21.4±1.2m | 16.3±3.5 |
| Phosphatidylethanolamine | |||
| ΣSFA | 45.2±7.7 | 45.1±4.6 | 43.4±4.4 |
| ΣMUFA | 11.4±1.8 | 11.7±1.0 | 16.7±2.8 |
| ΣPUFA n-6 | 13.4±2.9 | 12.7±1.7 | 13.4±1.3 |
| ΣPUFA n-3 | 30.0±4.2 | 30.6±2.9 | 26.5±4.2 |
| UI | 246.1±1.8 | 247.1±1.1 | 230.0±7.9 |
| UI (18:1 n-9) | 11.0±0.3 | 11.5±0.2 | 16.0±2.2 |
| UI (18:2 n-6) | 0±0 | 0±0 | 0±0 |
| UI (20:4 n-6) | 41.9±1.9s | 34.1±2.1m | 34.7±3.2 |
| UI (22:6 n-3) | 187.0±3.9 | 184.6±4.4 | 158.0±13.6 |
| Phosphatidylserine | |||
| ΣSFA | 45.2±7.9 | 47.2±6.2 | 46.5±3.8 |
| ΣMUFA | 18.8±7.6 | 19.4±5.2 | 26.2±5.6 |
| ΣPUFA n-6 | 5.0±1.4 | 5.1±0.6 | 5.5±0.7 |
| ΣPUFA n-3 | 31.1±2.8 | 28.4±1.6 | 21.8±2.7 |
| UI | 230.9±12.0 | 211.3±11.6 | 178.2±19.7 |
| UI (18:1 n-9) | 16.9±3.2 | 17.5±2.3 | 24.1±3.8 |
| UI (18:2 n-6) | 0±0 | 0±0 | 0±0 |
| UI (20:4 n-6) | 16.1±0.9c | 13.5±1.8 | 12.1±1.3m |
| UI (22:6 n-3) | 196.0±11.2 | 175.3±13.3 | 135.0±24.0 |
| Phosphatidic acid | |||
| ΣSFA | 43.6±2.5 | 37.9±3.8 | 44.9±6.4 |
| ΣMUFA | 27.2±2.7 | 42.5±9.9 | 40.2±8.7 |
| ΣPUFA n-6 | 7.0±1.3 | 6.1±0.8 | 2.8±0.7 |
| ΣPUFA n-3 | 22.2±0.7 | 13.6±1.9 | 12.0±2.4 |
| UI | 188.7±2.2 | 150.9±10.9 | 130.3±19.9 |
| UI (18:1 n-9) | 27.0±1.0 | 41.1±4.4 | 39.0±4.4 |
| UI (18:2 n-6) | 0±0 | 0±0 | 0±0 |
| UI (20:4 n-6) | 27.5±3.3c | 26.3±5.8 | 10.7±1.4m |
| UI (22:6 n-3) | 134.2±5.9 | 83.4±10.8 | 80.6±24.4 |
SFA, saturated fatty acid ; MUFA, monounsaturated fatty acid; PUFA,polyunsaturated fatty acid; Σ, total; UI, unsaturation index (the number double bonds per 100 fatty acid molecules)
Superscript letters indicate significant differences between the values derived for mouse (m), sheep (s) and cow (c) at a minimum P<0.05. n-3, n-6, n-9 denote the location of the first double bond from the methyl end of the molecule. Values are mean ± s.e.m. (N=4)