Glycolysis/gluconeogenesis genes (PC1, 54.12%; PC2, 15.55%) | |||||||||||||||
Number | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
E.C. # | 1.1.1.27 | 1.2.1.12 | 1.2.1.3 | 2.4.1.1 | 2.7.1.11 | 2.7.1.40 | 2.7.2.3 | 3.1.3.11 | 4.1.2.13 | 4.2.1.11 | 5.3.1.1 | 5.3.1.9 | 5.3.1.9 | 5.4.2.1 | 5.4.2.2 |
Abbrev. | LDHB | GAPD | ALDH9A1 | PYGM | PFKM | PKM2 | PGK1 | FBP1 | ALDOA | ENO1 | TPI1 | GPI | GPI | PGAM1 | PGM1 |
PC1 | 0.15 | –0.63 | 0.37 | 0.01 | –0.33 | –0.26 | 0.26 | 0.09 | 0.12 | 0.18 | 0.1 | –0.05 | 0.09 | –0.17 | 0.3 |
PC2 | –0.11 | 0.13 | 0.02 | –0.02 | 0.45 | –0.19 | 0.02 | 0.75 | 0.24 | 0.05 | 0.04 | –0.2 | –0.1 | –0.04 | 0.22 |
TCA genes (PC1, 44.40%; PC2, 35.16%) | |||||||||||||||
Number | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | ||
E.C. # | 1.1.1.41 | 1.1.1.41 | 1.2.4.1 | 1.2.4.1 | 1.2.4.2 | 1.3.5.1? | 1.8.1.4 | 2.3.1.12 | 4.1.1.32 | 4.1.3.7 | 4.2.1.2 | 6.2.1.1 | 6.2.1.4 | ||
Abbrev. | IDH2 | IDH3A | PDHA1 | PDHB | OGDH | SDHC | DLD | DLST | PCK2 | CS | FH | ACAS2 | SUCLG1 | ||
PC1 | –0.12 | 0.36 | 0.12 | 0.04 | 0.18 | –0.29 | 0.01 | 0.25 | 0.33 | 0.07 | –0.64 | 0.3 | –0.23 | ||
PC2 | 0.06 | –0.28 | –0.14 | –0.06 | 0 | 0.34 | –0.05 | –0.21 | –0.22 | –0.15 | –0.75 | –0.2 | 0.23 | ||
Oxidative phosphorylation genes (PC1, 48.76%; PC2, 16.30%) | |||||||||||||||
Number | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
E.C. # | 1.10.2.2 | 1.10.2.2 | 1.10.2.2 | 1.10.2.2 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 |
Abbrev. | UQCRC2 | UQCR10 | UQCRC1 | UQCRFS1 | NDUFA4 | NDUFA1 | NDUFA10 | NDUFA9 | NDUFB6 | MTND2 | NDUFAB1 | NDUFS4 | NUFS1 | NUOG | NDUFV2 |
PC1 | 0.12 | –0.22 | –0.07 | 0.2 | –0.15 | –0.11 | 0.01 | –0.07 | 0 | –0.2 | 0.14 | 0.11 | 0.17 | 0.31 | –0.07 |
PC2 | –0.04 | 0.01 | –0.03 | 0.02 | –0.03 | –0.08 | –0.07 | –0.07 | –0.08 | 0 | –0.04 | –0.14 | –0.08 | 0.17 | –0.04 |
Number | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
E.C. # | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.9.3.1 | 1.9.3.1 | 1.9.3.1 | 1.9.3.1 | 1.9.3.1 | 1.9.3.1 |
Abbrev. | NDUFA4 | MTND5 | NDUFS3 | NDUFA8 | NDUFB2 | NDUFB8 | NDUFB9 | NDUFB1 | NDUFB10 | COXII | COX4I1 | COX4I2 | COX5A | COX6A1 | COX6B |
PC1 | –0.22 | –0.01 | –0.07 | –0.17 | –0.24 | –0.2 | –0.21 | –0.07 | 0.04 | –0.13 | 0.06 | 0 | 0.03 | –0.2 | 0.09 |
PC2 | 0.12 | 0 | 0.02 | 0.02 | –0.29 | 0.04 | 0.05 | –0.44 | –0.09 | 0.08 | –0.26 | –0.11 | –0.12 | –0.06 | 0.01 |
Number | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | |
E.C. # | 1.9.3.1 | 1.9.3.1 | 1.9.3.1 | 1.9.3.1 | 3.6.1.34 | 3.6.1.34 | 3.6.1.34 | 3.6.1.34 | 3.6.1.34 | 3.6.1.34 | 3.6.1.34 | 3.6.1.34 | 3.6.1.34 | 3.6.1.35 | |
Abbrev. | COX7A2 | COX8H | COX7C | COX8L | ATP5B | MTATP6 | ATP5H | ATP5A2 | ATP5D | ATP5C1 | ATP5F1 | ATP6V0C | ATP6V0D1 | ATP6V1C1 | |
PC1 | –0.06 | –0.18 | 0.05 | 0.22 | –0.25 | –0.21 | –0.15 | 0.15 | 0.01 | –0.23 | 0.12 | 5.00% | 8.00% | 18.00% | |
PC2 | –0.07 | –0.03 | –0.11 | 0.15 | 0.02 | 0.25 | –0.02 | –0.14 | –0.05 | –0.07 | –0.57 |
Glycolysis/gluconeogenesis genes (PC1, 54.12%; PC2, 15.55%) | |||||||||||||||
Number | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
E.C. # | 1.1.1.27 | 1.2.1.12 | 1.2.1.3 | 2.4.1.1 | 2.7.1.11 | 2.7.1.40 | 2.7.2.3 | 3.1.3.11 | 4.1.2.13 | 4.2.1.11 | 5.3.1.1 | 5.3.1.9 | 5.3.1.9 | 5.4.2.1 | 5.4.2.2 |
Abbrev. | LDHB | GAPD | ALDH9A1 | PYGM | PFKM | PKM2 | PGK1 | FBP1 | ALDOA | ENO1 | TPI1 | GPI | GPI | PGAM1 | PGM1 |
PC1 | 0.15 | –0.63 | 0.37 | 0.01 | –0.33 | –0.26 | 0.26 | 0.09 | 0.12 | 0.18 | 0.1 | –0.05 | 0.09 | –0.17 | 0.3 |
PC2 | –0.11 | 0.13 | 0.02 | –0.02 | 0.45 | –0.19 | 0.02 | 0.75 | 0.24 | 0.05 | 0.04 | –0.2 | –0.1 | –0.04 | 0.22 |
TCA genes (PC1, 44.40%; PC2, 35.16%) | |||||||||||||||
Number | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | ||
E.C. # | 1.1.1.41 | 1.1.1.41 | 1.2.4.1 | 1.2.4.1 | 1.2.4.2 | 1.3.5.1? | 1.8.1.4 | 2.3.1.12 | 4.1.1.32 | 4.1.3.7 | 4.2.1.2 | 6.2.1.1 | 6.2.1.4 | ||
Abbrev. | IDH2 | IDH3A | PDHA1 | PDHB | OGDH | SDHC | DLD | DLST | PCK2 | CS | FH | ACAS2 | SUCLG1 | ||
PC1 | –0.12 | 0.36 | 0.12 | 0.04 | 0.18 | –0.29 | 0.01 | 0.25 | 0.33 | 0.07 | –0.64 | 0.3 | –0.23 | ||
PC2 | 0.06 | –0.28 | –0.14 | –0.06 | 0 | 0.34 | –0.05 | –0.21 | –0.22 | –0.15 | –0.75 | –0.2 | 0.23 | ||
Oxidative phosphorylation genes (PC1, 48.76%; PC2, 16.30%) | |||||||||||||||
Number | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
E.C. # | 1.10.2.2 | 1.10.2.2 | 1.10.2.2 | 1.10.2.2 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 |
Abbrev. | UQCRC2 | UQCR10 | UQCRC1 | UQCRFS1 | NDUFA4 | NDUFA1 | NDUFA10 | NDUFA9 | NDUFB6 | MTND2 | NDUFAB1 | NDUFS4 | NUFS1 | NUOG | NDUFV2 |
PC1 | 0.12 | –0.22 | –0.07 | 0.2 | –0.15 | –0.11 | 0.01 | –0.07 | 0 | –0.2 | 0.14 | 0.11 | 0.17 | 0.31 | –0.07 |
PC2 | –0.04 | 0.01 | –0.03 | 0.02 | –0.03 | –0.08 | –0.07 | –0.07 | –0.08 | 0 | –0.04 | –0.14 | –0.08 | 0.17 | –0.04 |
Number | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
E.C. # | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.6.5.3 | 1.9.3.1 | 1.9.3.1 | 1.9.3.1 | 1.9.3.1 | 1.9.3.1 | 1.9.3.1 |
Abbrev. | NDUFA4 | MTND5 | NDUFS3 | NDUFA8 | NDUFB2 | NDUFB8 | NDUFB9 | NDUFB1 | NDUFB10 | COXII | COX4I1 | COX4I2 | COX5A | COX6A1 | COX6B |
PC1 | –0.22 | –0.01 | –0.07 | –0.17 | –0.24 | –0.2 | –0.21 | –0.07 | 0.04 | –0.13 | 0.06 | 0 | 0.03 | –0.2 | 0.09 |
PC2 | 0.12 | 0 | 0.02 | 0.02 | –0.29 | 0.04 | 0.05 | –0.44 | –0.09 | 0.08 | –0.26 | –0.11 | –0.12 | –0.06 | 0.01 |
Number | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | |
E.C. # | 1.9.3.1 | 1.9.3.1 | 1.9.3.1 | 1.9.3.1 | 3.6.1.34 | 3.6.1.34 | 3.6.1.34 | 3.6.1.34 | 3.6.1.34 | 3.6.1.34 | 3.6.1.34 | 3.6.1.34 | 3.6.1.34 | 3.6.1.35 | |
Abbrev. | COX7A2 | COX8H | COX7C | COX8L | ATP5B | MTATP6 | ATP5H | ATP5A2 | ATP5D | ATP5C1 | ATP5F1 | ATP6V0C | ATP6V0D1 | ATP6V1C1 | |
PC1 | –0.06 | –0.18 | 0.05 | 0.22 | –0.25 | –0.21 | –0.15 | 0.15 | 0.01 | –0.23 | 0.12 | 5.00% | 8.00% | 18.00% | |
PC2 | –0.07 | –0.03 | –0.11 | 0.15 | 0.02 | 0.25 | –0.02 | –0.14 | –0.05 | –0.07 | –0.57 |
Factor coefficients for each gene for the first two principal components are listed in parentheses. `%' is the percentage variance in gene expression explained by each PC. Many enzymes have more than one protein subunit, and numbers are used to identify these subunits. Full names of all genes are provided in Table S1 in supplementary material. Data from Oleksiak et al.(Oleksiak et al., 2005)