The Company of Biologists

Table 1.

The diuretic activity and potency of N- and C-terminal deletion analogues of Tenmo-ADFb

Sequence	Analogue	EC₅₀ (μmol l^–1)	95% CL (μmol l^–1)	Response maximum (%)
YDDGSYKPHIYGF–OH	ADFb	0.59	0.44–0.80	90±9
DDGSYKPHIYGF–OH	ADFb[2–13]	0.79	0.40–1.54	87±8
KPHIYGF–OH	ADFb[7–13]	0.14	0.07–0.32	92±8
PHIYGF–OH	ADFb[8–13]	Not active	Not active
YDDGSYKPHIYG –OH	ADFb[1–12]	0.50	0.06–4.41	87±11

Sequence	Analogue	EC₅₀ (μmol l^–1)	95% CL (μmol l^–1)	Response maximum (%)
YDDGSYKPHIYGF–OH	ADFb	0.59	0.44–0.80	90±9
DDGSYKPHIYGF–OH	ADFb[2–13]	0.79	0.40–1.54	87±8
KPHIYGF–OH	ADFb[7–13]	0.14	0.07–0.32	92±8
PHIYGF–OH	ADFb[8–13]	Not active	Not active
YDDGSYKPHIYG –OH	ADFb[1–12]	0.50	0.06–4.41	87±11