. | . | . | Pre-injection (0–5 min) . | . | . | Post-injection (5–30 min) . | . | . | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Peptides . | Doses (pmol) . | N . | fV (breaths min–1) . | VAMP (a.u.) . | VTOT (a.u.) . | ΔfV (breaths min–1) . | ΔVAMP (a.u.) . | ΔVTOT (a.u.) . | ||||
NPγ | 0 (vehicle) | 16 | 71.2±2.5 | 29.4±2.5 | 2210±189 | –1.4±1.1 | –1.1±0.6 | –140.0±66 | ||||
25 | 8 | 71.6±2.6 | 31.6±5.5 | 2203±372 | 15.7±4.2* | –8.4±4.1 | –343±227 | |||||
50 | 9 | 74.2±3.2 | 26.9±2.6 | 2013 + 240 | 18.4±4.1* | –14.6±2.6* | –945±236* | |||||
100 | 8 | 70.2±5.1 | 32.6±4.4 | 2340±424 | 26.9±2.3* | –23.9±3.6* | –14851±369* | |||||
SP | 0 (vehicle) | 16 | 66.2±1.8 | 27.9±2.9 | 2179±339 | –1.6±0.7 | –3.2±1.4 | –178±91 | ||||
250 | 10 | 69.6±3.1 | 28.4±3.7 | 1992±273 | 18.2±4.2* | –16.7±3.5* | –1071±246* | |||||
NKA | 0 (vehicle) | 16 | 68.2±2.6 | 33.9±4.0 | 2353±312 | 1.5±0.6 | 1.8±1.3 | 153±98 | ||||
250 | 9 | 67.8±3.0 | 32.0±3.0 | 2196±244 | 10.6±2.6 | –14.7±3.0* | –898±218* |
. | . | . | Pre-injection (0–5 min) . | . | . | Post-injection (5–30 min) . | . | . | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Peptides . | Doses (pmol) . | N . | fV (breaths min–1) . | VAMP (a.u.) . | VTOT (a.u.) . | ΔfV (breaths min–1) . | ΔVAMP (a.u.) . | ΔVTOT (a.u.) . | ||||
NPγ | 0 (vehicle) | 16 | 71.2±2.5 | 29.4±2.5 | 2210±189 | –1.4±1.1 | –1.1±0.6 | –140.0±66 | ||||
25 | 8 | 71.6±2.6 | 31.6±5.5 | 2203±372 | 15.7±4.2* | –8.4±4.1 | –343±227 | |||||
50 | 9 | 74.2±3.2 | 26.9±2.6 | 2013 + 240 | 18.4±4.1* | –14.6±2.6* | –945±236* | |||||
100 | 8 | 70.2±5.1 | 32.6±4.4 | 2340±424 | 26.9±2.3* | –23.9±3.6* | –14851±369* | |||||
SP | 0 (vehicle) | 16 | 66.2±1.8 | 27.9±2.9 | 2179±339 | –1.6±0.7 | –3.2±1.4 | –178±91 | ||||
250 | 10 | 69.6±3.1 | 28.4±3.7 | 1992±273 | 18.2±4.2* | –16.7±3.5* | –1071±246* | |||||
NKA | 0 (vehicle) | 16 | 68.2±2.6 | 33.9±4.0 | 2353±312 | 1.5±0.6 | 1.8±1.3 | 153±98 | ||||
250 | 9 | 67.8±3.0 | 32.0±3.0 | 2196±244 | 10.6±2.6 | –14.7±3.0* | –898±218* |
fV, ventilation rate; VAMP,ventilation amplitude; VTOT, total ventilation; NPγ,neuropeptide γ; SP, substance P; NKA, neurokinin A; a.u., arbitrary units
All data are presented as means ± s.e.m.; N=number of trout. Values and statistics are from Figs 2, 4 and 5. Changes in ventilatory variables following the action of 5 pmol NPγ and 50 and 100 pmol SP and NKA were omitted since they were not significant (see text and Figs 2, 4 and 5)
P<0.05 vs pre-injection values