Chemical compounds used for in vivo studies on isolated vela and in vitro studies on intact larvae
| . | . | . | . | . | Concentration tested (mol 1−1) . | . | |
|---|---|---|---|---|---|---|---|
| Chemical . | Common name . | Distributor . | Action in vertebrates . | Effectiveness in molluscs . | On isolated velum . | In intact larvae . | |
| 5-Hydroxy-tryptamine hydrochloride | Serotonin | Sigma | 10−6-10−9 | 10−4-10−6 | |||
| Arterenol bitartrate salt | Nor-epinephrine | Sigma | 10−6-10−9 | 10−4-10−6 | |||
| Dopamine hydrochloride | Dopamine | Sigma | 10−6-10−9 | 10−4-10−6 | |||
| Mianserin hydrochloride | Mianserin | Sigma | 5-HT2 receptor antagonist(Willins et al., 1999) | (Diefenbach et al., 1991; Uhler et al., 2000) | NA | 10−5 | |
| Fluoxetine hydrochloride | Fluoxetine | Eli Lillya | Serotonin re-uptake inhibitor (Fuller,1996) | (Couper and Leise, 1996; Fong et al., 1998; Uhler et al., 2000) | NA | 10−5 | |
| Spiperone hydrochloride | Spiperone | Sigma | D2 antagonist (Amenta et al.,1999); alpha-adrenergic antagonist(Testa et al., 1993);5-HT2/5-HT1 (Geerts et al.,1999) | (Green et al., 1996; Pechenik et al., 2002) | NA | 10−5 | |
| Haloperidol | Haloperidol | Sigma | D2-4 receptor antagonist with possible action on 5-HT receptors(Seeman, 2002) | (Heiss et al., 1976; Voronezhskaya et al., 1993) | NA | 10−5 | |
| Alprenolol | Alprenolol | Sigma | β-adrenergic antagonist (Surman and Doggrell, 1993) | (Marsden and Hassessian, 1986)(polychaete) | NA | 10−5 | |
| FMRFamide | FMRFamide | Sigma | 10−6-10−9 | 10−6 | |||
| Leu-enkephalin | Leu-enkephalin | Sigma | 10−6-10−9 | 10−6 | |||
| . | . | . | . | . | Concentration tested (mol 1−1) . | . | |
|---|---|---|---|---|---|---|---|
| Chemical . | Common name . | Distributor . | Action in vertebrates . | Effectiveness in molluscs . | On isolated velum . | In intact larvae . | |
| 5-Hydroxy-tryptamine hydrochloride | Serotonin | Sigma | 10−6-10−9 | 10−4-10−6 | |||
| Arterenol bitartrate salt | Nor-epinephrine | Sigma | 10−6-10−9 | 10−4-10−6 | |||
| Dopamine hydrochloride | Dopamine | Sigma | 10−6-10−9 | 10−4-10−6 | |||
| Mianserin hydrochloride | Mianserin | Sigma | 5-HT2 receptor antagonist(Willins et al., 1999) | (Diefenbach et al., 1991; Uhler et al., 2000) | NA | 10−5 | |
| Fluoxetine hydrochloride | Fluoxetine | Eli Lillya | Serotonin re-uptake inhibitor (Fuller,1996) | (Couper and Leise, 1996; Fong et al., 1998; Uhler et al., 2000) | NA | 10−5 | |
| Spiperone hydrochloride | Spiperone | Sigma | D2 antagonist (Amenta et al.,1999); alpha-adrenergic antagonist(Testa et al., 1993);5-HT2/5-HT1 (Geerts et al.,1999) | (Green et al., 1996; Pechenik et al., 2002) | NA | 10−5 | |
| Haloperidol | Haloperidol | Sigma | D2-4 receptor antagonist with possible action on 5-HT receptors(Seeman, 2002) | (Heiss et al., 1976; Voronezhskaya et al., 1993) | NA | 10−5 | |
| Alprenolol | Alprenolol | Sigma | β-adrenergic antagonist (Surman and Doggrell, 1993) | (Marsden and Hassessian, 1986)(polychaete) | NA | 10−5 | |
| FMRFamide | FMRFamide | Sigma | 10−6-10−9 | 10−6 | |||
| Leu-enkephalin | Leu-enkephalin | Sigma | 10−6-10−9 | 10−6 | |||
Additional references to transmitters are given in the text or involve common knowledge. NA, not applicable.
Eli Lilly, Toronto, ON, Canada.