. | Saline (N=7) . | . | . | 5% CO2 (N=6) . | . | . | 10% CO2 (N=6) . | . | . | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
. | Pre . | Peak . | P . | Pre . | Peak . | P . | Pre . | Peak . | P . | ||||||
Pda (cmH2O) | 35.5±1.6 | 38.7±1.7 | 0.021 | 35.6±1.4 | 39.4±1.6 | 0.09 | 35.5±1.4 | 38.1±1.6 | 0.32 | ||||||
V̇b (ml min−1kg−1) | 20.4±2.0 | 26.9±2.8 | <0.001 | 23.9±2.9 | 28.4±3.2 | 0.015 | 24.1±2.5 | 30.1±3.6 | 0.016 | ||||||
Rs (cm H2O min kg ml−1) | 1.82±0.13 | 1.87±0.16 | 0.012 | 1.61±0.20 | 1.77±0.19 | 0.013 | 1.50±0.13 | 1.59±0.15 | 0.008 | ||||||
fh (min−1) | 34.5±3.9 | 26.9±2.8 | 0.003 | 33.1±4.7 | 25.9±3.2 | 0.74 | 32.0±4.1 | 27.9±3.6 | 0.67 | ||||||
VAMP (cm) | 0.30±0.06 | 0.40±0.07 | 0.008 | 0.35±0.08 | 0.41±0.08 | 0.11 | 0.34±0.08 | 0.39±0.05 | 0.43 |
. | Saline (N=7) . | . | . | 5% CO2 (N=6) . | . | . | 10% CO2 (N=6) . | . | . | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
. | Pre . | Peak . | P . | Pre . | Peak . | P . | Pre . | Peak . | P . | ||||||
Pda (cmH2O) | 35.5±1.6 | 38.7±1.7 | 0.021 | 35.6±1.4 | 39.4±1.6 | 0.09 | 35.5±1.4 | 38.1±1.6 | 0.32 | ||||||
V̇b (ml min−1kg−1) | 20.4±2.0 | 26.9±2.8 | <0.001 | 23.9±2.9 | 28.4±3.2 | 0.015 | 24.1±2.5 | 30.1±3.6 | 0.016 | ||||||
Rs (cm H2O min kg ml−1) | 1.82±0.13 | 1.87±0.16 | 0.012 | 1.61±0.20 | 1.77±0.19 | 0.013 | 1.50±0.13 | 1.59±0.15 | 0.008 | ||||||
fh (min−1) | 34.5±3.9 | 26.9±2.8 | 0.003 | 33.1±4.7 | 25.9±3.2 | 0.74 | 32.0±4.1 | 27.9±3.6 | 0.67 | ||||||
VAMP (cm) | 0.30±0.06 | 0.40±0.07 | 0.008 | 0.35±0.08 | 0.41±0.08 | 0.11 | 0.34±0.08 | 0.39±0.05 | 0.43 |
Pda, arterial blood pressure; V̇b, cardiac output; Rs, systemic vascular resistance; fh,heart rate; VAMP, ventilation amplitude.
Saline was enriched with either 5% or 10% CO2.
`Pre', data compiled for 10 s prior to the injection; `Peak', the 10 s interval during the 100 s post injection, for which the greatest response was detected; `P', the P value for the one-way RM-ANOVA carried out on the full data set (i.e. the values for the 20 s prior to and 100 s post saline injection).
Values are means ± 1 s.e.m.