. | Number of genes . | . | . | . | . | . | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
. | Day 1 Infarct zone . | . | Day 1 remote zone . | . | Day 28 remote zone . | . | |||||
Functional class . | Up . | Down . | Up . | Down . | Up . | Down . | |||||
Signal transduction | 79 | 186 | 101 | 25 | 10 | 0 | |||||
Transcription | 23 | 76 | 21 | 11 | 3 | 2 | |||||
Inflammation | 28 | 66 | 61 | 4 | 7 | 0 | |||||
Apoptosis | 4 | 33 | 10 | 2 | 3 | 0 | |||||
Protein synthesis | 4 | 26 | 17 | 10 | 2 | 1 | |||||
Growth factors | 10 | 18 | 15 | 2 | 3 | 0 | |||||
Metabolism | 15 | 79 | 27 | 14 | 6 | 2 | |||||
Energy transduction | 17 | 43 | 10 | 10 | 1 | 1 | |||||
Calcium regulation | 12 | 29 | 4 | 1 | 1 | 0 | |||||
Myocardial contraction | 1 | 13 | 2 | 1 | / | / | |||||
ECM remodelling | 5 | 8 | 5 | 1 | 3 | 2 | |||||
Angiogenesis | 1 | 6 | 4 | 2 | 1 | 0 |
. | Number of genes . | . | . | . | . | . | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
. | Day 1 Infarct zone . | . | Day 1 remote zone . | . | Day 28 remote zone . | . | |||||
Functional class . | Up . | Down . | Up . | Down . | Up . | Down . | |||||
Signal transduction | 79 | 186 | 101 | 25 | 10 | 0 | |||||
Transcription | 23 | 76 | 21 | 11 | 3 | 2 | |||||
Inflammation | 28 | 66 | 61 | 4 | 7 | 0 | |||||
Apoptosis | 4 | 33 | 10 | 2 | 3 | 0 | |||||
Protein synthesis | 4 | 26 | 17 | 10 | 2 | 1 | |||||
Growth factors | 10 | 18 | 15 | 2 | 3 | 0 | |||||
Metabolism | 15 | 79 | 27 | 14 | 6 | 2 | |||||
Energy transduction | 17 | 43 | 10 | 10 | 1 | 1 | |||||
Calcium regulation | 12 | 29 | 4 | 1 | 1 | 0 | |||||
Myocardial contraction | 1 | 13 | 2 | 1 | / | / | |||||
ECM remodelling | 5 | 8 | 5 | 1 | 3 | 2 | |||||
Angiogenesis | 1 | 6 | 4 | 2 | 1 | 0 |
Infarct zone becomes a scar at day 28.
Numbers in bold = major changes.
Day 1 or 28 indicates the time after surgery (rearranged from LaFramboise et al., 2005).
ECM, extra-cellular matrix.