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Table 3.

Distribution of several genes significantly altered after an experimental myocardial infarction in rats, by functional classification (into genes regulating growth, contractility and metabolism)

Number of genes
Day 1 Infarct zone
Day 1 remote zone
Day 28 remote zone
Functional classUpDownUpDownUpDown
Signal transduction 79 186 101 25 10 
Transcription 23 76 21 11 3 
Inflammation 28 66 61 7 
Apoptosis 33 10 3 
Protein synthesis 26 17 10 2 
Growth factors 10 18 15 3 
Metabolism 15 79 27 14 6 
Energy transduction 17 43 10 10 
Calcium regulation 12 29 4 1 
Myocardial contraction 13 2 
ECM remodelling 8 5 3 
Angiogenesis 6 4 1 
Number of genes
Day 1 Infarct zone
Day 1 remote zone
Day 28 remote zone
Functional classUpDownUpDownUpDown
Signal transduction 79 186 101 25 10 
Transcription 23 76 21 11 3 
Inflammation 28 66 61 7 
Apoptosis 33 10 3 
Protein synthesis 26 17 10 2 
Growth factors 10 18 15 3 
Metabolism 15 79 27 14 6 
Energy transduction 17 43 10 10 
Calcium regulation 12 29 4 1 
Myocardial contraction 13 2 
ECM remodelling 8 5 3 
Angiogenesis 6 4 1 

Infarct zone becomes a scar at day 28.

Numbers in bold = major changes.

Day 1 or 28 indicates the time after surgery (rearranged from LaFramboise et al., 2005).

ECM, extra-cellular matrix.

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