The Company of Biologists

Table 2.

Relative distribution of nAChR-subunits in brain and small intestine extracts, as determined by liquid-phase RIAs

		[nAChR] (pmol kg^-1 wet tissue)^*
mAb	Specificity	Brain	Small intestine
mAb 210	α3, α5	177±7	140±30
mAb 313	α3	73±23	40±7
mAb 299	α4	254±53	5±3.6
mAb 306	α7	730±80	41±7
mAb 295	β2	775±35	66±6
mAb 337	β4	13±1	1±0.2

		[nAChR] (pmol kg^-1 wet tissue)^*
mAb	Specificity	Brain	Small intestine
mAb 210	α3, α5	177±7	140±30
mAb 313	α3	73±23	40±7
mAb 299	α4	254±53	5±3.6
mAb 306	α7	730±80	41±7
mAb 295	β2	775±35	66±6
mAb 337	β4	13±1	1±0.2

Expressed as either [³H]epibatidine binding sites forα3-nAChRs ± s.d. (N=3) or[¹²⁵I]αBgT binding sites for α7-nAChRs ± s.d. (N=3).