. | . | Monoamines and monoamine metabolites (pg mg−1 tissue) . | . | . | . | |||
---|---|---|---|---|---|---|---|---|
Brain region and exposure duration . | NH4Cl treatments (μmol 1−1) . | 5-HT . | 5-HIAA . | DA . | DOPAC . | |||
24 h | ||||||||
HYP | 0 | 1168.7±109.7a | 159.1±8.9a | |||||
500 | 104.7±125.2a | 186.2±15.8a | ||||||
750 | 995.2±48.4a | 225.1±17.4a | ||||||
1000 | 857.4±105.3a | 222.2±21.7a | ||||||
TEL | 0 | 403.9±19.7a | 104.3±5.3a | |||||
500 | 347.6±65.4a | 94.6±10.0a | ||||||
750 | 254.7±25.1b | 79.5±8.8a | ||||||
1000 | 270.4±22.4b | 92.9±9.72a | ||||||
PB | 0 | 129.7±16.4a | 45.5±4.7a | 70.1±5.9a,b | 10.0±0.8a | |||
500 | 148.5±25.5a | 60.0±8.8a | 79.6±11.6a | 13.7±1.9a | ||||
750 | 104.6±14.7a | 46.3±7.1a | 44.7±4.8b | 13.7±2.1a | ||||
1000 | 97.4±7.9a | 49.5±5.6a | 44.3±4.4b | 13.0±1.3a | ||||
96 h | ||||||||
HYP | 0 | 1428.6±92.1a | 194.6±17.3a | |||||
500 | 1071.5±104.1b | 177.4±21.4a | ||||||
750 | 1119.1±101.0a,b | 192.0±19.4a | ||||||
1000 | 888.9±39.5b | 177.4±9.8a | ||||||
TEL | 0 | 324.4±24.7a | 98.1±7.7a,b | |||||
500 | 237.0±23.9a | 83.5±6.2a | ||||||
750 | 284.4±30.3a | 113.6±7.9b | ||||||
263.9±42.5a | 99.6±8.8a,b | |||||||
PB | 0 | 137.8±16.7a | 54.8±4.3a | 76.7±5.0a | 12.6±0.7a | |||
500 | 103.8±11.9a | 46.8±4.6a | 58.9±7.2a,b | 14.1±2.0a | ||||
750 | 94.3±9.3a,b | 55.3±8.5a | 50.0±5.0b,c | 12.3±1.6a | ||||
1000 | 82.3±7.6b | 47.5±3.8a | 38.7±3.1c | 12.5±1.4a |
. | . | Monoamines and monoamine metabolites (pg mg−1 tissue) . | . | . | . | |||
---|---|---|---|---|---|---|---|---|
Brain region and exposure duration . | NH4Cl treatments (μmol 1−1) . | 5-HT . | 5-HIAA . | DA . | DOPAC . | |||
24 h | ||||||||
HYP | 0 | 1168.7±109.7a | 159.1±8.9a | |||||
500 | 104.7±125.2a | 186.2±15.8a | ||||||
750 | 995.2±48.4a | 225.1±17.4a | ||||||
1000 | 857.4±105.3a | 222.2±21.7a | ||||||
TEL | 0 | 403.9±19.7a | 104.3±5.3a | |||||
500 | 347.6±65.4a | 94.6±10.0a | ||||||
750 | 254.7±25.1b | 79.5±8.8a | ||||||
1000 | 270.4±22.4b | 92.9±9.72a | ||||||
PB | 0 | 129.7±16.4a | 45.5±4.7a | 70.1±5.9a,b | 10.0±0.8a | |||
500 | 148.5±25.5a | 60.0±8.8a | 79.6±11.6a | 13.7±1.9a | ||||
750 | 104.6±14.7a | 46.3±7.1a | 44.7±4.8b | 13.7±2.1a | ||||
1000 | 97.4±7.9a | 49.5±5.6a | 44.3±4.4b | 13.0±1.3a | ||||
96 h | ||||||||
HYP | 0 | 1428.6±92.1a | 194.6±17.3a | |||||
500 | 1071.5±104.1b | 177.4±21.4a | ||||||
750 | 1119.1±101.0a,b | 192.0±19.4a | ||||||
1000 | 888.9±39.5b | 177.4±9.8a | ||||||
TEL | 0 | 324.4±24.7a | 98.1±7.7a,b | |||||
500 | 237.0±23.9a | 83.5±6.2a | ||||||
750 | 284.4±30.3a | 113.6±7.9b | ||||||
263.9±42.5a | 99.6±8.8a,b | |||||||
PB | 0 | 137.8±16.7a | 54.8±4.3a | 76.7±5.0a | 12.6±0.7a | |||
500 | 103.8±11.9a | 46.8±4.6a | 58.9±7.2a,b | 14.1±2.0a | ||||
750 | 94.3±9.3a,b | 55.3±8.5a | 50.0±5.0b,c | 12.3±1.6a | ||||
1000 | 82.3±7.6b | 47.5±3.8a | 38.7±3.1c | 12.5±1.4a |
Values are means ± 1 s.e.m.(N=8-12). Values for a given brain region and exposure duration that do not share a common letter are significantly different from each other(P<0.05).
HYP, hypothalamus; TEL, telencephalon; PB, posterior brain; 5-HT,serotonin; 5-HIAA, 5-hydroxyindole acetic acid; DA, dopamine; DOPAC,3,4-dihydroxyphenylacetic acid.