The Company of Biologists

Table 1.

Sites of erythropoietin (EPO) and EPO receptor expression in the central nervous system

	EPO							EPO receptor
	Rodents			Humans			Rodents			Humans
Cell types	In vitro	In vivo	In vitro	In vivo	In vitro	In vivo	In vitro	In vivo	References
Neurones	+	+	-	+	+	+	+	+	Bernaudin et al. (1999, 2000); Siren et al.(2001b); Morishita et al.(1997); Nagai et al.(2001)
Astrocytes	+	+	+	+	+	+	+	+	Masuda et al. (1994, 1997); Marti et al.(1996); Bernaudin et al.(1999), 2000); Siren et al.(2001b)
Microglial cells	NA	NA	-	NA	NA	NA	+	NA	Nagai et al. (2001)
Oligodendrocytes	+	NA	-	NA	+	NA	-	NA	Nagai et al. (2001); Sugawa et al. (2002)
Endothelial cells	-	?	NA	?	+	+	+	+	Anagnostou et al. (1994);Yamaji et al. (1996); Brines et al. (2000)

	EPO							EPO receptor
	Rodents			Humans			Rodents			Humans
Cell types	In vitro	In vivo	In vitro	In vivo	In vitro	In vivo	In vitro	In vivo	References
Neurones	+	+	-	+	+	+	+	+	Bernaudin et al. (1999, 2000); Siren et al.(2001b); Morishita et al.(1997); Nagai et al.(2001)
Astrocytes	+	+	+	+	+	+	+	+	Masuda et al. (1994, 1997); Marti et al.(1996); Bernaudin et al.(1999), 2000); Siren et al.(2001b)
Microglial cells	NA	NA	-	NA	NA	NA	+	NA	Nagai et al. (2001)
Oligodendrocytes	+	NA	-	NA	+	NA	-	NA	Nagai et al. (2001); Sugawa et al. (2002)
Endothelial cells	-	?	NA	?	+	+	+	+	Anagnostou et al. (1994);Yamaji et al. (1996); Brines et al. (2000)

+, expression detected; -, no expression; NA, not analysed; ?, not proven.