Table 2.

Activity profile of TMOF and its analogues on mosquito larvae

TMOF analoguesLC50 (mmol l-1)Activity (%)
YDPAPPPPPP 0.2±0.015ab 100 
YDPAPPPPPPR >71.6 0 
(H)6 IEGRYDPAPPPPPP 0.34±0.032b 59 
YDPAPPPP 0.44±0.05b 45 
YDPAPP 0.64±0.032b 31 
YDPAP 0.64±0.028b 31 
YDPAPR 0.24±0.01a 80 
YDPAPK ≫2.9 0 
YDPA 0.21±0.01a 95 
YDPAR 0.12±0.017a 166 
(YDPAR)4 0.095±0.007b 210 
YDP 2.3±0.36b 9 
YDPR 0.24±0.02a 80 
YD 1.24±0.05b 16 
DPA 0.4±0.03b 50 
DPAR 0.46±0.011b 43 
(DPAR)4 0.048±0.002b 417 
DPAP 0.98±0.017b 20 
DPAPPPPPP 0.44±0.015b 45 
PAPPPPPP 0.58±0.029b 34 
APPPPPP 1.18±0.065b 17 
PPPPPP 1.1±0.025b 18 
PPPP 1.5±0.085b 13 
PP 1.83±0.07b 11 
PAP 6.4±0.23b 3 
TMOF analoguesLC50 (mmol l-1)Activity (%)
YDPAPPPPPP 0.2±0.015ab 100 
YDPAPPPPPPR >71.6 0 
(H)6 IEGRYDPAPPPPPP 0.34±0.032b 59 
YDPAPPPP 0.44±0.05b 45 
YDPAPP 0.64±0.032b 31 
YDPAP 0.64±0.028b 31 
YDPAPR 0.24±0.01a 80 
YDPAPK ≫2.9 0 
YDPA 0.21±0.01a 95 
YDPAR 0.12±0.017a 166 
(YDPAR)4 0.095±0.007b 210 
YDP 2.3±0.36b 9 
YDPR 0.24±0.02a 80 
YD 1.24±0.05b 16 
DPA 0.4±0.03b 50 
DPAR 0.46±0.011b 43 
(DPAR)4 0.048±0.002b 417 
DPAP 0.98±0.017b 20 
DPAPPPPPP 0.44±0.015b 45 
PAPPPPPP 0.58±0.029b 34 
APPPPPP 1.18±0.065b 17 
PPPPPP 1.1±0.025b 18 
PPPP 1.5±0.085b 13 
PP 1.83±0.07b 11 
PAP 6.4±0.23b 3 

TMOF and its analogues were fed to first instar mosquito larvae (three groups of 12 larvae per group) as described in Table 1. Larval mortality was followed for 6 days. Lethal concentrations at 50% mortality (LC50)were obtained by Probit analyses and are expressed as means of three determinations ± s.e.m. Statistical analyses were done using two-tailed Student's t-test of paired samples. Mortality in control wells containing Brewer's yeast and without TMOF and its analogues was 0-5%.

a

No significant difference between analogues and TMOF (LC50)(P>0.05).

b

Significant difference between analogues and TMOF (LC50) at 0.001<P<0.05.

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