Approaches to antimalarial drug discovery and development
| Approach . | Examples . | References . |
|---|---|---|
| Optimize therapy with existing agents | Amodiaquine/sulfadoxine/pyrimethamine | Staedke et al., 2001; Dorsey et al., 2002; Schellenberg et al., 2002 |
| Amodiaquine/artesunate | Adjuik et al., 2002 | |
| Artesunate/sulfadoxine/pyrimethamine | von Seidlein et al., 2000; Dorsey et al., 2002 | |
| Artesunate/mefloquine | Price et al., 1997 | |
| Artemether/lumefantrine | Lefevre et al., 2001 | |
| Chlorproguanil/dapsone | Nzila et al., 2000; Mutabingwa et al., 2001; Kublin et al., 2002 | |
| Chlorproguanil/dapsone/artesunate | - | |
| Atovaquone/proguanil | Vaidya, 2001 | |
| Develop analogs of existing agents | New aminoquinolines | Raynes et al., 1999; Kaschula et al., 2002 |
| New endoperoxides | Vennerstrom et al., 2000; Posner et al., 2003 | |
| New folate antagonists | Tarnchompoo et al., 2002 | |
| Natural products | New natural products | Tagboto and Townson, 2001 |
| Compounds active against other diseases | Folate antagonists | Plowe, 2001 |
| Antibiotics | Clough and Wilson, 2001 | |
| Atovaquone | Vaidya, 2001 | |
| Iron chelators | Loyevsky and Gordeuk, 2001 | |
| Drug resistance reversers | Verapamil, desipramine, trifluoperazine | van Schalkwyk et al., 2001 |
| Chlorpheniramine | Sowunmi et al., 1997 | |
| Compounds active against new targets | See Table 2 | - |
| Approach . | Examples . | References . |
|---|---|---|
| Optimize therapy with existing agents | Amodiaquine/sulfadoxine/pyrimethamine | Staedke et al., 2001; Dorsey et al., 2002; Schellenberg et al., 2002 |
| Amodiaquine/artesunate | Adjuik et al., 2002 | |
| Artesunate/sulfadoxine/pyrimethamine | von Seidlein et al., 2000; Dorsey et al., 2002 | |
| Artesunate/mefloquine | Price et al., 1997 | |
| Artemether/lumefantrine | Lefevre et al., 2001 | |
| Chlorproguanil/dapsone | Nzila et al., 2000; Mutabingwa et al., 2001; Kublin et al., 2002 | |
| Chlorproguanil/dapsone/artesunate | - | |
| Atovaquone/proguanil | Vaidya, 2001 | |
| Develop analogs of existing agents | New aminoquinolines | Raynes et al., 1999; Kaschula et al., 2002 |
| New endoperoxides | Vennerstrom et al., 2000; Posner et al., 2003 | |
| New folate antagonists | Tarnchompoo et al., 2002 | |
| Natural products | New natural products | Tagboto and Townson, 2001 |
| Compounds active against other diseases | Folate antagonists | Plowe, 2001 |
| Antibiotics | Clough and Wilson, 2001 | |
| Atovaquone | Vaidya, 2001 | |
| Iron chelators | Loyevsky and Gordeuk, 2001 | |
| Drug resistance reversers | Verapamil, desipramine, trifluoperazine | van Schalkwyk et al., 2001 |
| Chlorpheniramine | Sowunmi et al., 1997 | |
| Compounds active against new targets | See Table 2 | - |