The Company of Biologists

Table 3.

Characterization of 87 full-length clones from a cDNA library ofIxodes scapularis salivary glands

Group and sequence name	Best match to NR protein database	E-value	Best CDD match	E-value	Comment	MW^¹	SP^²	MW^³	pI
Group 1
TB103	gi\|15428308\|AF209921_1 (AF209921) 1	2.00E-41			Similar to 14 kDa salivary gland protein	11.4	21	9.3	4.1
ISL1025	gi\|15428308\|AF209921_1 (AF209921) 1	1.00E-34			Similar to 14 kDa salivary gland protein	13.6	21	11.5	9.19
ISL1129	gi\|15428308\|AF209921_1 (AF209921) 1	2.00E-40			Similar to 14 kDa salivary gland protein	13.6	21	11.5	9.14
ISL1342	gi\|15428308\|AF209921_1 (AF209921) 1	4.00E-40			Similar to 14 kDa salivary gland protein	11.4	21	9.3	4.13
ISL932	gi\|15428308\|AF209921_1 (AF209921) 1	1.00E-34			Similar to 14 kDa salivary gland protein	13.7	21	11.6	9.25
TA07	gi\|15428308\|AF209921_1 (AF209921) 1	5.00E-34			Similar to 14 kDa salivary gland protein	13.7	21	11.6	8.87
TA135	gi\|15428308\|AF209921_1 (AF209921) 1	3.00E-36			Similar to 14 kDa salivary gland protein	13.4	21	11.4	8.92
TA170	gi\|15428308\|AF209921_1 (AF209921) 1	3.00E-34			Similar to 14 kDa salivary gland protein	13.6	21	11.6	9.19
TA204	gi\|15428308\|AF209921_1 (AF209921) 1	7.00E-34			Similar to 14 kDa salivary gland protein	13.6	21	11.5	9.19
TA256	gi\|15428308\|AF209921_1 (AF209921) 1	1.00E-34			Similar to 14 kDa salivary gland protein	13.6	21	11.5	9.19
TA260	gi\|15428308\|AF209921_1 (AF209921) 1	1.00E-34			Similar to 14 kDa salivary gland protein	13.7	21	11.6	9.28
ISTB12	gi\|15428308\|AF209921_1 (AF209921) 1	1.00E-32			Similar to 14 kDa salivary gland protein	13.9	21	11.8	9.41
TB131	gi\|15428308\|AF209921_1 (AF209921) 1	3.00E-44			Similar to 14 kDa salivary gland protein	13.4	21	11.4	7.52
TB149	gi\|15428308\|AF209921_1 (AF209921) 1	4.00E-33			Similar to 14 kDa salivary gland protein	13.6	21	11.5	9.34
TB152	gi\|15428308\|AF209921_1 (AF209921) 1	4.00E-34			Similar to 14 kDa salivary gland protein	13.7	21	11.5	9.08
TB179	gi\|15428308\|AF209921_1 (AF209921) 1	3.00E-34			Similar to 14 kDa salivary gland protein	13.7	21	11.5	9.25
TB205	gi\|15428308\|AF209921_1 (AF209921) 1	2.00E-37			Similar to 14 kDa salivary gland protein	13.5	21	11.5	9.28
TB222	gi\|15428308\|AF209921_1 (AF209921) 1	3.00E-42			Similar to 14 kDa salivary gland protein	13.5	21	11.5	9.32
TB223	gi\|15428308\|AF209921_1 (AF209921) 1	3.00E-45			Similar to 14 kDa salivary gland protein	13.3	21	11.3	9.41
TB376	gi\|15428308\|AF209921_1 (AF209921) 1	3.00E-39			Similar to 14 kDa salivary gland protein	11.2	21	9.1	4.67
TB47	gi\|15428308\|AF209921_1 (AF209921) 1	2.00E-50			Similar to 14 kDa salivary gland protein	14	22	11.9	9.65
TB51	gi\|15428308\|AF209921_1 (AF209921) 1	1.00E-42			Similar to 14 kDa salivary gland protein	13.3	21	11.4	5.23
Group 2
TB239_cluster30					Unknown function	8.5	19	6.5	9.89
TA149_cluster48	gi\|7505725\|T23573 hypothetical prot	5.00E-05	pfam00014 Kunitz_BPT1	6.00E-05	Protease inhibitor — Kunitz domain	8.7	27	5.9	9.61
TA340_cluster134	gi\|124810\|IP52_ANESU PROTEASE INHIB	0.004			Protease inhibitor?	8.8	20	6.9	4.68
ISTA464_cluster7	gi\|124810\|IP52_ANESU PROTEASE INHIB	0.004			Protease inhibitor?	8.9	19	7	4.28
ISTB382_cluster51	gi\|10726827\| (AE003765) CG 18436 gen	8.00E-04	Smart smart00131 KU	3.00E-04	Protease inhibitor — Kunitz domain	9	22		5.53
TB192_cluster54	gi\|7500203\|T16210 hypothetical prot	0.047			Unknown function	9	17	7.3	9.33
TA230_cluster124					Unknown function	9.1	20	7.1	4.63
TA304_cluster16	gi\|3881447\| (Z19157) contains simil	0.079			Unknown function	9.2	22	7	8.83
ISTB31_cluster108	gi\|7498832\|T34212 hypothetical prot	0.009			Unknown function	9.2	21	7.1	4.29
TA244_cluster31	gi\|7497910\|T20219 hypothetical prot	9.00E-06	pfam00014 Kunitz_BPT1	1.00E-04	Protease inhibitor — Kunitz domain	9.9	27	7.2	6.48
TB11_cluster26	gi\|7506657\|T32060 hypothetical prot	5.00E-06	Smart smart00131 KU	2.00E-05	Protease inhibitor — Kunitz domain	10.2	27	7.5	9.3
ISTA12_cluster45	gi\|6164595\|AF078161_1 (AF078161) 1a	0.001			Protease inhibitor?	10.3	19	8.2	5.84
TB76B	gi\|6164595\|AF078161_1 (AF078161) 1a	0.058			Unknown function	10.4	19	8.4	10
Group 3
TB135B					Unknown function	5.4	19	3.5	3.9
TA78_cluster2					Unknown function	6.3	19	4.4	6.03
TA37B					Unknown function	6.3	19	4.4	4.83
TB184B					Unknown function	6.3	19	4.4	4.83
TB194B					Unknown function	6.4	19	4.4	4.83
TB07B	gi\|114248\|ASF1_HELAN ANTHER-SPECIFI	5.00E-04			Proline rich peptide	6.5	19	4.6	7.61
TA58_cluster29					Unknown function	6.5	19	4.6	5.51
TB73_cluster15	gi\|114248\|ASF1_HELAN ANTHER-SPECIFI	0.003			Proline rich peptide	6.6	19	4.6	9.78
TA20B					Unknown function	6.6	19	4.6	4.97
TB138B					Unknown function	6.6	19	4.5	5.33
TB111B					Unknown function	6.7	19	4.7	7.61
TB313B	gi\|13751843\| (AL590734) hypothetica	0.029			Unknown function	6.8	19	4.8	9.3
Group 4
TB396B	gi\|15428348\|AF278575_1 (AF278575) S	6.00E-37			Similar to Salp 10	9.9	17	8.1	5.75
TB50B	gi\|15428348\|AF278575_1 (AF278575) S	2.00E-35			Similar to Salp 10	9.9	17	8.1	4.9
ISTA15_cluster42	gi\|15428348\|AF278575_1 (AF278575) S	5.00E-24			Similar to Salp 10	9.9	19	7.9	5.25
TB386B	gi\|15428348\|AF278575_1 (AF278575) S	4.00E-37			Similar to Salp 10	10.2	22	7.9	7.58
TA13	gi\|15428348\|AF278575_1 (AF278575) S	4.00E-27			Similar to Salp 10	10.2	17	8.5	7.47
TB42_cluster20	gi\|15428348\|AF278575_1 (AF278575) S	8.00E-25			Similar to Salp 10	10.4	22	8.1	7.48
TB144B	gi\|15428348\|AF278575_1 (AF278575) S	2.00E-34			Similar to Salp 10	10.4	17	8.7	9.27
TB15B	gi\|15428348\|AF278575_1 (AF278575) S	6.00E-34			Similar to Salp 10	10.4	17	8.7	9.27
Group 5
ISL1022_cluster264	gi\|10726827\| (AE003765) CG18436 gen	3.00E-18			Protease inhibitor	35.7	19	33.7	8.24
ISL1352_cluster68	gi\|10726827\| (AE003765) CG18436 gen	2.00E-14			Protease inhibitor?	36.3	19	34.2	9.29
ISL1228_cluster344	gi\|10726827\| (AE003765) CG18436 gen	3.00E-13	Smart smart00131 KU	6.00E-04	Protease inhibitor—Kunitz domain	38	22	35.5	9.46
Group 6
ISL1040_cluster18			pfam02098 His_binding	3.00E-04	Histamine binding domain	34.2	17	32.6	5.73
ISL1276_cluster363	gi\|8470378\|HBP2_RHIAP FEMALE-SPECIF	2.00E-04			Similar to Rhipicephalushistamine binding ptn	36.6	18	34.6	5.15
Group 7
ISL929_cluster233	gi\|15428290\|AF209912_1 (AF209912) t	2.00E-31			Similar to I. scapularis thrombospondin	12.8	23	10.2	9.24
ISL1373_cluster33	gi\|15428290\|AF209912_1 (AF209912) t	7.00E-26	pfam02853 ACR	5.00E-04	Similar to I. scapularis thrombospondin	13.5	18	11.6	5.45
Remaining sequences
Similar to other salivary proteins
ISL1083_cluster9	gi\|15428310\|AF209922_1 (AF209922) 2	1.00E-117			95% identical to 25 kda salivary antigen	25.3	20	23.3	9.66
TB103_cluster1	gi\|15428308\|AF209921_1 (AF209921) 1	2.00E-39			Similar to 14 kDa salivary gland protein	10.7	15	9.3	4.14
Histamine Binding, not Group 6
ISL868_cluster49		pfam02098 His_binding		3.00E-04	Histamine binding domain	25.4	21	23.3	6.41
Protease inhibitors
ISL 1095_cluster291	gi\|7521905\|T18544 alpha-2-macroglob	1.00E-87	pfam00207 A2M	5.00E-50	Protease inhibitor — A2M partial sequence	42.3			5.67
ISL888_cluster62			pfam00031 cystatin	3.00E-08	Protease inhibitor — Cystatin	14.3	24	11.9	4.93
ISTA397_cluster168	gi\|15077002\|AF286029_1 (AF286029) i	5.00E-59	Smart smart00131 KU	1.00E-11	Protease inhibitor — Ixolaris like	18.7	26	16	5.58
ISL1156_cluster318	gi\|400070\|ISH1_STOHE KUNITZ-TYPE PR	6.00E-15	Smart smart00131 KU	3.00E-15	Protease inhibitor — Kunitz domain	9	23	6.6	10.5
ISL1268_cluster360	gi\|862467\|(D32211) limulus intrace	9.00E-26	pfam00079 serpin	3.00E-30	Protease inhibitor — Serpin type	23.7	25	20.8	5.81
Enzymes
ISL1194_5nuc	gi\|12644305\|5NTD_BOOMI C95	1.00E-107	pfam01009 5_nucleotidase	1.00E-70	5′-nucleotidase\|apyrase secreted	64.6	21	62.5	5.6
ISL1316_cluster379	gi\|12060148\|AF106704_1 (AF106704) p	1.00E-34	pfam00450 serine_carbpept	3.00E-31	Carboxypeptidase — secreted	38.2	29	34.9	6.8
ISL812_cluster188	gi\|3970893\| (AB020544) serin protei	1.00E-14	Smart smart00020 Tryp_SPc	3.00E-23	Serine protease — signal anchor	41.4	SA		4.73
ISL1033_cluster65	gi\|5911708\| (AJ269650) hypothetical	0	pfam01421 Reprolysin	4.00E-13	Zn Metalloprotease Secreted	44.1	49^*	36.7	8.94
ISL1324_cluster383	gi\|5911708\| (AJ269650) hypothetical	1.00E-158	pfam01421 Reprolysin	1.00E-14	Zn Metalloprotease Secreted	46.1	72^*	38.2	9.0
ISL939_cluster238	gi\|12644364\|NUDM_DROME NADH-UBIQUIN	1.00E-82	pfam01712 dNK	2.00E-14	NADH-Ubiquinone oxireductase	47.8	19	45.8	6.11
Unknown function
ISTB418_cluster179	gi\|14733532\| DKFZP564N1362 protein	6.00E-06			Unknown function	7.2	27	4.3	10.1
IS1818					Secreted in saliva	7.8	23	5.3	8.68
ISL1188_cluster39					Unknown function	8.3	18	6.4	4.34
ISL914_cluster14					Unknown function	8.9	19	7	6.34
ISTA482_cluster44					Unknown function	10.3	18	8.4	10.5
ISL1068_cluster5					Unknown function	11.5	20	9.4	8.72
TA310_cluster133					Unknown function	11.1	22	8.9	9.17
ISL1182_cluster23					Unknown function	12.2	19	10.2	9.07
TB277_cluster160					Unknown function	20.7	20	18.7	4.98
ISL942_cluster53	gi\|11496688\| B. burgdorferi predict	7.00E-04			Unknown function	24.7	19	22.5	5.38
ISL1270_cluster22	gi\|8072217\|AF260530_1 (AF260530) Ds	0.043			Unknown function — Adhesion?	24.5	18	22.7	5.54

Group and sequence name	Best match to NR protein database	E-value	Best CDD match	E-value	Comment	MW^¹	SP^²	MW^³	pI
Group 1
TB103	gi\|15428308\|AF209921_1 (AF209921) 1	2.00E-41			Similar to 14 kDa salivary gland protein	11.4	21	9.3	4.1
ISL1025	gi\|15428308\|AF209921_1 (AF209921) 1	1.00E-34			Similar to 14 kDa salivary gland protein	13.6	21	11.5	9.19
ISL1129	gi\|15428308\|AF209921_1 (AF209921) 1	2.00E-40			Similar to 14 kDa salivary gland protein	13.6	21	11.5	9.14
ISL1342	gi\|15428308\|AF209921_1 (AF209921) 1	4.00E-40			Similar to 14 kDa salivary gland protein	11.4	21	9.3	4.13
ISL932	gi\|15428308\|AF209921_1 (AF209921) 1	1.00E-34			Similar to 14 kDa salivary gland protein	13.7	21	11.6	9.25
TA07	gi\|15428308\|AF209921_1 (AF209921) 1	5.00E-34			Similar to 14 kDa salivary gland protein	13.7	21	11.6	8.87
TA135	gi\|15428308\|AF209921_1 (AF209921) 1	3.00E-36			Similar to 14 kDa salivary gland protein	13.4	21	11.4	8.92
TA170	gi\|15428308\|AF209921_1 (AF209921) 1	3.00E-34			Similar to 14 kDa salivary gland protein	13.6	21	11.6	9.19
TA204	gi\|15428308\|AF209921_1 (AF209921) 1	7.00E-34			Similar to 14 kDa salivary gland protein	13.6	21	11.5	9.19
TA256	gi\|15428308\|AF209921_1 (AF209921) 1	1.00E-34			Similar to 14 kDa salivary gland protein	13.6	21	11.5	9.19
TA260	gi\|15428308\|AF209921_1 (AF209921) 1	1.00E-34			Similar to 14 kDa salivary gland protein	13.7	21	11.6	9.28
ISTB12	gi\|15428308\|AF209921_1 (AF209921) 1	1.00E-32			Similar to 14 kDa salivary gland protein	13.9	21	11.8	9.41
TB131	gi\|15428308\|AF209921_1 (AF209921) 1	3.00E-44			Similar to 14 kDa salivary gland protein	13.4	21	11.4	7.52
TB149	gi\|15428308\|AF209921_1 (AF209921) 1	4.00E-33			Similar to 14 kDa salivary gland protein	13.6	21	11.5	9.34
TB152	gi\|15428308\|AF209921_1 (AF209921) 1	4.00E-34			Similar to 14 kDa salivary gland protein	13.7	21	11.5	9.08
TB179	gi\|15428308\|AF209921_1 (AF209921) 1	3.00E-34			Similar to 14 kDa salivary gland protein	13.7	21	11.5	9.25
TB205	gi\|15428308\|AF209921_1 (AF209921) 1	2.00E-37			Similar to 14 kDa salivary gland protein	13.5	21	11.5	9.28
TB222	gi\|15428308\|AF209921_1 (AF209921) 1	3.00E-42			Similar to 14 kDa salivary gland protein	13.5	21	11.5	9.32
TB223	gi\|15428308\|AF209921_1 (AF209921) 1	3.00E-45			Similar to 14 kDa salivary gland protein	13.3	21	11.3	9.41
TB376	gi\|15428308\|AF209921_1 (AF209921) 1	3.00E-39			Similar to 14 kDa salivary gland protein	11.2	21	9.1	4.67
TB47	gi\|15428308\|AF209921_1 (AF209921) 1	2.00E-50			Similar to 14 kDa salivary gland protein	14	22	11.9	9.65
TB51	gi\|15428308\|AF209921_1 (AF209921) 1	1.00E-42			Similar to 14 kDa salivary gland protein	13.3	21	11.4	5.23
Group 2
TB239_cluster30					Unknown function	8.5	19	6.5	9.89
TA149_cluster48	gi\|7505725\|T23573 hypothetical prot	5.00E-05	pfam00014 Kunitz_BPT1	6.00E-05	Protease inhibitor — Kunitz domain	8.7	27	5.9	9.61
TA340_cluster134	gi\|124810\|IP52_ANESU PROTEASE INHIB	0.004			Protease inhibitor?	8.8	20	6.9	4.68
ISTA464_cluster7	gi\|124810\|IP52_ANESU PROTEASE INHIB	0.004			Protease inhibitor?	8.9	19	7	4.28
ISTB382_cluster51	gi\|10726827\| (AE003765) CG 18436 gen	8.00E-04	Smart smart00131 KU	3.00E-04	Protease inhibitor — Kunitz domain	9	22		5.53
TB192_cluster54	gi\|7500203\|T16210 hypothetical prot	0.047			Unknown function	9	17	7.3	9.33
TA230_cluster124					Unknown function	9.1	20	7.1	4.63
TA304_cluster16	gi\|3881447\| (Z19157) contains simil	0.079			Unknown function	9.2	22	7	8.83
ISTB31_cluster108	gi\|7498832\|T34212 hypothetical prot	0.009			Unknown function	9.2	21	7.1	4.29
TA244_cluster31	gi\|7497910\|T20219 hypothetical prot	9.00E-06	pfam00014 Kunitz_BPT1	1.00E-04	Protease inhibitor — Kunitz domain	9.9	27	7.2	6.48
TB11_cluster26	gi\|7506657\|T32060 hypothetical prot	5.00E-06	Smart smart00131 KU	2.00E-05	Protease inhibitor — Kunitz domain	10.2	27	7.5	9.3
ISTA12_cluster45	gi\|6164595\|AF078161_1 (AF078161) 1a	0.001			Protease inhibitor?	10.3	19	8.2	5.84
TB76B	gi\|6164595\|AF078161_1 (AF078161) 1a	0.058			Unknown function	10.4	19	8.4	10
Group 3
TB135B					Unknown function	5.4	19	3.5	3.9
TA78_cluster2					Unknown function	6.3	19	4.4	6.03
TA37B					Unknown function	6.3	19	4.4	4.83
TB184B					Unknown function	6.3	19	4.4	4.83
TB194B					Unknown function	6.4	19	4.4	4.83
TB07B	gi\|114248\|ASF1_HELAN ANTHER-SPECIFI	5.00E-04			Proline rich peptide	6.5	19	4.6	7.61
TA58_cluster29					Unknown function	6.5	19	4.6	5.51
TB73_cluster15	gi\|114248\|ASF1_HELAN ANTHER-SPECIFI	0.003			Proline rich peptide	6.6	19	4.6	9.78
TA20B					Unknown function	6.6	19	4.6	4.97
TB138B					Unknown function	6.6	19	4.5	5.33
TB111B					Unknown function	6.7	19	4.7	7.61
TB313B	gi\|13751843\| (AL590734) hypothetica	0.029			Unknown function	6.8	19	4.8	9.3
Group 4
TB396B	gi\|15428348\|AF278575_1 (AF278575) S	6.00E-37			Similar to Salp 10	9.9	17	8.1	5.75
TB50B	gi\|15428348\|AF278575_1 (AF278575) S	2.00E-35			Similar to Salp 10	9.9	17	8.1	4.9
ISTA15_cluster42	gi\|15428348\|AF278575_1 (AF278575) S	5.00E-24			Similar to Salp 10	9.9	19	7.9	5.25
TB386B	gi\|15428348\|AF278575_1 (AF278575) S	4.00E-37			Similar to Salp 10	10.2	22	7.9	7.58
TA13	gi\|15428348\|AF278575_1 (AF278575) S	4.00E-27			Similar to Salp 10	10.2	17	8.5	7.47
TB42_cluster20	gi\|15428348\|AF278575_1 (AF278575) S	8.00E-25			Similar to Salp 10	10.4	22	8.1	7.48
TB144B	gi\|15428348\|AF278575_1 (AF278575) S	2.00E-34			Similar to Salp 10	10.4	17	8.7	9.27
TB15B	gi\|15428348\|AF278575_1 (AF278575) S	6.00E-34			Similar to Salp 10	10.4	17	8.7	9.27
Group 5
ISL1022_cluster264	gi\|10726827\| (AE003765) CG18436 gen	3.00E-18			Protease inhibitor	35.7	19	33.7	8.24
ISL1352_cluster68	gi\|10726827\| (AE003765) CG18436 gen	2.00E-14			Protease inhibitor?	36.3	19	34.2	9.29
ISL1228_cluster344	gi\|10726827\| (AE003765) CG18436 gen	3.00E-13	Smart smart00131 KU	6.00E-04	Protease inhibitor—Kunitz domain	38	22	35.5	9.46
Group 6
ISL1040_cluster18			pfam02098 His_binding	3.00E-04	Histamine binding domain	34.2	17	32.6	5.73
ISL1276_cluster363	gi\|8470378\|HBP2_RHIAP FEMALE-SPECIF	2.00E-04			Similar to Rhipicephalushistamine binding ptn	36.6	18	34.6	5.15
Group 7
ISL929_cluster233	gi\|15428290\|AF209912_1 (AF209912) t	2.00E-31			Similar to I. scapularis thrombospondin	12.8	23	10.2	9.24
ISL1373_cluster33	gi\|15428290\|AF209912_1 (AF209912) t	7.00E-26	pfam02853 ACR	5.00E-04	Similar to I. scapularis thrombospondin	13.5	18	11.6	5.45
Remaining sequences
Similar to other salivary proteins
ISL1083_cluster9	gi\|15428310\|AF209922_1 (AF209922) 2	1.00E-117			95% identical to 25 kda salivary antigen	25.3	20	23.3	9.66
TB103_cluster1	gi\|15428308\|AF209921_1 (AF209921) 1	2.00E-39			Similar to 14 kDa salivary gland protein	10.7	15	9.3	4.14
Histamine Binding, not Group 6
ISL868_cluster49		pfam02098 His_binding		3.00E-04	Histamine binding domain	25.4	21	23.3	6.41
Protease inhibitors
ISL 1095_cluster291	gi\|7521905\|T18544 alpha-2-macroglob	1.00E-87	pfam00207 A2M	5.00E-50	Protease inhibitor — A2M partial sequence	42.3			5.67
ISL888_cluster62			pfam00031 cystatin	3.00E-08	Protease inhibitor — Cystatin	14.3	24	11.9	4.93
ISTA397_cluster168	gi\|15077002\|AF286029_1 (AF286029) i	5.00E-59	Smart smart00131 KU	1.00E-11	Protease inhibitor — Ixolaris like	18.7	26	16	5.58
ISL1156_cluster318	gi\|400070\|ISH1_STOHE KUNITZ-TYPE PR	6.00E-15	Smart smart00131 KU	3.00E-15	Protease inhibitor — Kunitz domain	9	23	6.6	10.5
ISL1268_cluster360	gi\|862467\|(D32211) limulus intrace	9.00E-26	pfam00079 serpin	3.00E-30	Protease inhibitor — Serpin type	23.7	25	20.8	5.81
Enzymes
ISL1194_5nuc	gi\|12644305\|5NTD_BOOMI C95	1.00E-107	pfam01009 5_nucleotidase	1.00E-70	5′-nucleotidase\|apyrase secreted	64.6	21	62.5	5.6
ISL1316_cluster379	gi\|12060148\|AF106704_1 (AF106704) p	1.00E-34	pfam00450 serine_carbpept	3.00E-31	Carboxypeptidase — secreted	38.2	29	34.9	6.8
ISL812_cluster188	gi\|3970893\| (AB020544) serin protei	1.00E-14	Smart smart00020 Tryp_SPc	3.00E-23	Serine protease — signal anchor	41.4	SA		4.73
ISL1033_cluster65	gi\|5911708\| (AJ269650) hypothetical	0	pfam01421 Reprolysin	4.00E-13	Zn Metalloprotease Secreted	44.1	49^*	36.7	8.94
ISL1324_cluster383	gi\|5911708\| (AJ269650) hypothetical	1.00E-158	pfam01421 Reprolysin	1.00E-14	Zn Metalloprotease Secreted	46.1	72^*	38.2	9.0
ISL939_cluster238	gi\|12644364\|NUDM_DROME NADH-UBIQUIN	1.00E-82	pfam01712 dNK	2.00E-14	NADH-Ubiquinone oxireductase	47.8	19	45.8	6.11
Unknown function
ISTB418_cluster179	gi\|14733532\| DKFZP564N1362 protein	6.00E-06			Unknown function	7.2	27	4.3	10.1
IS1818					Secreted in saliva	7.8	23	5.3	8.68
ISL1188_cluster39					Unknown function	8.3	18	6.4	4.34
ISL914_cluster14					Unknown function	8.9	19	7	6.34
ISTA482_cluster44					Unknown function	10.3	18	8.4	10.5
ISL1068_cluster5					Unknown function	11.5	20	9.4	8.72
TA310_cluster133					Unknown function	11.1	22	8.9	9.17
ISL1182_cluster23					Unknown function	12.2	19	10.2	9.07
TB277_cluster160					Unknown function	20.7	20	18.7	4.98
ISL942_cluster53	gi\|11496688\| B. burgdorferi predict	7.00E-04			Unknown function	24.7	19	22.5	5.38
ISL1270_cluster22	gi\|8072217\|AF260530_1 (AF260530) Ds	0.043			Unknown function — Adhesion?	24.5	18	22.7	5.54

Other headings as in Table 1.

Molecular mass of the putative protein.

Site predicted to occur signal peptide cleavage, according to the SignalP program (^*).

Molecular mass of the putative mature protein.

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