. | N . | fH (beats min-1) . | Q̇pul (ml kg-1min-1) . | Q̇sys (ml kg-1min-1) . | Q̇tot (ml kg-1min-1) . | Vstot (ml kg-1) . | Ppul (kPa) . | Psys (kPa) . | Rpul (kPa ml-1 kg min) . | Rsys (kPa ml-1 kg min) . | Q̇pul/Q̇sys . |
---|---|---|---|---|---|---|---|---|---|---|---|
Group 1 | |||||||||||
Control | 6 | 35.8±2.7 | 74.1±13.8 | 33.9±5.4 | 107.9±16.9 | 3.1±0.5 | 2.29±0.18 | 3.23±0.26 | 0.04±0.01 | 0.12±0.03 | 2.38±0.41 |
Norepinephrine | 6 | 43.5±2.2a | 124.6±18.7a | 25.1±2.3 | 149.7±19.6a | 3.5±0.5 | 3.93±0.26a | 5.27±0.24a | 0.04±0.01 | 0.22±0.02a | 5.05±0.83a |
Phenylephrine | 6 | 36.6±2.6 | 107.7±16.6a | 22.7±2.0 | 130.5±16.5 | 3.7±0.6 | 3.06±0.17a | 4.49±0.21a | 0.03±0.01 | 0.21±0.02a | 4.94±0.86a |
Propanolol | 6 | 23.0±1.8a | 40.5±11.6a | 23.8±5.4 | 64.3±10.6a | 2.9±0.6 | 2.09±0.26 | 3.07±0.32 | 0.09±0.03a | 0.16±0.04 | 2.14±0.73 |
Norepinephrine | 6 | 28.7±2.1b | 64.3±12.7 | 15.6±3.6 | 80.0±12.3 | 2.9±0.6 | 3.52±0.28b | 4.60±0.26b | 0.08±0.02 | 0.40±0.11b | 5.60±1.49b |
Phenylephrine | 6 | 25.1±1.6 | 52.0±10.9 | 20.3±3.3 | 72.3±12.2 | 2.9±0.6 | 2.82±0.38 | 3.73±0.42 | 0.09±0.04 | 0.22±0.05 | 2.84±0.52 |
Phentolamine | 6 | 20.0±1.6 | 11.6±1.8b | 14.9±2.8 | 26.5±3.7b | 1.3±0.1b | 1.22±0.28b | 1.38±0.32b | 0.12±0.04 | 0.11±0.02 | 1.00±0.32 |
Group 2 | |||||||||||
Control | 6 | 35.4±3.4 | 46.6±8.0 | 22.0±2.8 | 68.7±9.1 | 2.0±0.3 | 2.26±0.21 | 3.13±0.26 | 0.05±0.01 | 0.16±0.03 | 2.30±0.43 |
Norepinephrine | 6 | 42.8±2.4a | 102.3±15.1a | 16.0±2.3 | 118.3±13.6a | 2.9±0.4a | 4.43±0.49a | 5.82±0.58a | 0.05±0.01 | 0.41±0.08a | 7.81±2.29b |
Phenylephrine | 6 | 35.6±3.6 | 80.9±10.7a | 17.5±2.9 | 98.4±9.3a | 2.9±0.4a | 3.08±0.26a | 4.47±0.36a | 0.04±0.01 | 0.30±0.06a | 5.62±1.47b |
Phentolamine | 6 | 35.4±3.1 | 26.4±5.2a | 24.6±3.8 | 51.0±7.5 | 1.4±0.2 | 1.39±0.11a | 1.62±0.05a | 0.08±0.03 | 0.08±0.02a | 1.11±0.20 |
Norepinephrine | 6 | 38.0±2.4 | 40.3±12.1 | 27.8±4.0 | 68.0±13.2 | 1.8±0.4 | 1.76±0.09 | 2.30±0.15b | 0.08±0.02 | 0.10±0.02 | 1.51±0.37 |
Phenylephrine | 5 | 36.3±3.4 | 47.4±14.2 | 32.4±5.6 | 79.7±18.4b | 2.3±0.6 | 1.77±0.14 | 2.32±0.13b | 0.05±0.02 | 0.09±0.02 | 1.20±0.33 |
Propanolol | 6 | 23.0±3.0b | 23.3±7.2 | 26.8±7.8 | 50.1±14.0 | 2.1±0.6 | 1.64±0.17 | 2.35±0.21b | 0.13±0.05 | 0.16±0.07 | 0.98±0.22 |
. | N . | fH (beats min-1) . | Q̇pul (ml kg-1min-1) . | Q̇sys (ml kg-1min-1) . | Q̇tot (ml kg-1min-1) . | Vstot (ml kg-1) . | Ppul (kPa) . | Psys (kPa) . | Rpul (kPa ml-1 kg min) . | Rsys (kPa ml-1 kg min) . | Q̇pul/Q̇sys . |
---|---|---|---|---|---|---|---|---|---|---|---|
Group 1 | |||||||||||
Control | 6 | 35.8±2.7 | 74.1±13.8 | 33.9±5.4 | 107.9±16.9 | 3.1±0.5 | 2.29±0.18 | 3.23±0.26 | 0.04±0.01 | 0.12±0.03 | 2.38±0.41 |
Norepinephrine | 6 | 43.5±2.2a | 124.6±18.7a | 25.1±2.3 | 149.7±19.6a | 3.5±0.5 | 3.93±0.26a | 5.27±0.24a | 0.04±0.01 | 0.22±0.02a | 5.05±0.83a |
Phenylephrine | 6 | 36.6±2.6 | 107.7±16.6a | 22.7±2.0 | 130.5±16.5 | 3.7±0.6 | 3.06±0.17a | 4.49±0.21a | 0.03±0.01 | 0.21±0.02a | 4.94±0.86a |
Propanolol | 6 | 23.0±1.8a | 40.5±11.6a | 23.8±5.4 | 64.3±10.6a | 2.9±0.6 | 2.09±0.26 | 3.07±0.32 | 0.09±0.03a | 0.16±0.04 | 2.14±0.73 |
Norepinephrine | 6 | 28.7±2.1b | 64.3±12.7 | 15.6±3.6 | 80.0±12.3 | 2.9±0.6 | 3.52±0.28b | 4.60±0.26b | 0.08±0.02 | 0.40±0.11b | 5.60±1.49b |
Phenylephrine | 6 | 25.1±1.6 | 52.0±10.9 | 20.3±3.3 | 72.3±12.2 | 2.9±0.6 | 2.82±0.38 | 3.73±0.42 | 0.09±0.04 | 0.22±0.05 | 2.84±0.52 |
Phentolamine | 6 | 20.0±1.6 | 11.6±1.8b | 14.9±2.8 | 26.5±3.7b | 1.3±0.1b | 1.22±0.28b | 1.38±0.32b | 0.12±0.04 | 0.11±0.02 | 1.00±0.32 |
Group 2 | |||||||||||
Control | 6 | 35.4±3.4 | 46.6±8.0 | 22.0±2.8 | 68.7±9.1 | 2.0±0.3 | 2.26±0.21 | 3.13±0.26 | 0.05±0.01 | 0.16±0.03 | 2.30±0.43 |
Norepinephrine | 6 | 42.8±2.4a | 102.3±15.1a | 16.0±2.3 | 118.3±13.6a | 2.9±0.4a | 4.43±0.49a | 5.82±0.58a | 0.05±0.01 | 0.41±0.08a | 7.81±2.29b |
Phenylephrine | 6 | 35.6±3.6 | 80.9±10.7a | 17.5±2.9 | 98.4±9.3a | 2.9±0.4a | 3.08±0.26a | 4.47±0.36a | 0.04±0.01 | 0.30±0.06a | 5.62±1.47b |
Phentolamine | 6 | 35.4±3.1 | 26.4±5.2a | 24.6±3.8 | 51.0±7.5 | 1.4±0.2 | 1.39±0.11a | 1.62±0.05a | 0.08±0.03 | 0.08±0.02a | 1.11±0.20 |
Norepinephrine | 6 | 38.0±2.4 | 40.3±12.1 | 27.8±4.0 | 68.0±13.2 | 1.8±0.4 | 1.76±0.09 | 2.30±0.15b | 0.08±0.02 | 0.10±0.02 | 1.51±0.37 |
Phenylephrine | 5 | 36.3±3.4 | 47.4±14.2 | 32.4±5.6 | 79.7±18.4b | 2.3±0.6 | 1.77±0.14 | 2.32±0.13b | 0.05±0.02 | 0.09±0.02 | 1.20±0.33 |
Propanolol | 6 | 23.0±3.0b | 23.3±7.2 | 26.8±7.8 | 50.1±14.0 | 2.1±0.6 | 1.64±0.17 | 2.35±0.21b | 0.13±0.05 | 0.16±0.07 | 0.98±0.22 |
Values are means ± S.E.M.
Norepinephrine and phenylephrine, 5 μg kg-1; propanolol and phentolamine, 3 mg kg-1.
fH, heart rate; Q̇pul, pulmonary bloodflow; Q̇sys, systemic bloodflow; Q̇tot, total bloodflow; Vstot, stroke volume; Ppul, mean pulmonary blood pressure; Psys, mean systemic blood pressure; Rpul, pulmonary resistance; Rsys, systemic resistance; Q̇pul/Q̇sys;ratio of pulmonary and systemic blood flow.
signifies a significant difference from the control and bsignifies a significant difference following injection of the first antagonist. Statistical significance is taken at the level of P<0.05.