Effects of verapamil and cyanide on endolymph Ca2+ supply during Ca-loading experiments
| Endolymph [Ca] (mmol l-1) . | Proximal endolymph . | Distal endolymph . |
|---|---|---|
| Control (0 min) | 1.66±0.07 (8) | 0.79±0.07 (8) |
| Control (35 min) | 2.33±0.11 (8) | 1.38±0.10 (8) |
| Verapamil (35 min) | 2.49±0.12 (8) NS | 1.24±0.10 (8) NS |
| CN (35 min) | 2.21±0.11 (8) NS | 1.29±0.07 (8) NS |
| Endolymph [Ca] (mmol l-1) . | Proximal endolymph . | Distal endolymph . |
|---|---|---|
| Control (0 min) | 1.66±0.07 (8) | 0.79±0.07 (8) |
| Control (35 min) | 2.33±0.11 (8) | 1.38±0.10 (8) |
| Verapamil (35 min) | 2.49±0.12 (8) NS | 1.24±0.10 (8) NS |
| CN (35 min) | 2.21±0.11 (8) NS | 1.29±0.07 (8) NS |
Verapamil, 10-5 mol l-1; CN, 1 mmol l-1.
Values are means ± S.E.M., number of measurements in parentheses.
At t=0 the inner ear was perfused with a Ringer solution containing 2.8-3.2 mmol l-1 [Ca] and endolymph was sampled 35 min later.
Inhibitors, where used, were added to the Ringer solution at t=0 and endolymph was sampled 35 min later.
NS, no significant difference at 35 min between values obtained in controls and with inhibitors.