Accessory factors implicated in MSL targeting
| Factor . | Protein type . | Relevant mutant/RNAi phenotype . | References . |
|---|---|---|---|
| SET2 | H3K36 methyltransferase | Mutation/RNAi reduces MSL binding at active genes on X chromosome, not CES(ChIP of third instar larvae, SL2 cells) | (Larschan et al., 2007; Bell et al., 2008) |
| GAF (TRL) | GAGA-binding factor | Mutation is associated with an increased number of MSL sites on autosomes and the loss of a single CES (immunostaining of polytenes) | (Greenberg et al., 2004) |
| UNR | RNA-binding protein | Mutation/RNAi decreases MSL staining on X chromosome (immunostaining of polytenes, SL2 cells) | (Patalano et al., 2009) |
| NUP153 | Nuclear pore protein | ||
| MTOR | Nuclear pore-associated protein | RNAi depletion disrupts MSL localization to the X chromosome (immunostaining of SL2 cells) | (Mendjan et al., 2006) |
| Factor . | Protein type . | Relevant mutant/RNAi phenotype . | References . |
|---|---|---|---|
| SET2 | H3K36 methyltransferase | Mutation/RNAi reduces MSL binding at active genes on X chromosome, not CES(ChIP of third instar larvae, SL2 cells) | (Larschan et al., 2007; Bell et al., 2008) |
| GAF (TRL) | GAGA-binding factor | Mutation is associated with an increased number of MSL sites on autosomes and the loss of a single CES (immunostaining of polytenes) | (Greenberg et al., 2004) |
| UNR | RNA-binding protein | Mutation/RNAi decreases MSL staining on X chromosome (immunostaining of polytenes, SL2 cells) | (Patalano et al., 2009) |
| NUP153 | Nuclear pore protein | ||
| MTOR | Nuclear pore-associated protein | RNAi depletion disrupts MSL localization to the X chromosome (immunostaining of SL2 cells) | (Mendjan et al., 2006) |
CES, chromatin entry site; ChIP, chromatin immunoprecipitation; RNAi, RNA interference.