Table 1.

Variation in Chrd-/-;Nog+/- neonatal defects

Phenotypic groupRelative frequency
Midline class 14 (53%) 
Single nostril 9 (35%) 
Proboscis and synopthalmia/cyclopia 4 (15%) 
Cleft palate 1 (4%) 
Truncation class 4 (15%) 
Jaw class 8 (31%) 
Phenotypic groupRelative frequency
Midline class 14 (53%) 
Single nostril 9 (35%) 
Proboscis and synopthalmia/cyclopia 4 (15%) 
Cleft palate 1 (4%) 
Truncation class 4 (15%) 
Jaw class 8 (31%) 

Frequency of rostral phenotypes calculated from a subset of 26 affectedChrd;Nog neonates from consecutive outbred litters. Mutant pups containing more than one type of defect were classified according to the most severe defect.

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