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Table 4.

Phenotypic exacerbation in Sall4/Sall1 double heterozygous mice

Sall4+/-Sall1+/-Sall4+/- Sall1+/-
Renal agenesis* 0/43 (0%) 2/61 (3.3%) 16/38 (42.1%)§ 
Exencephaly* 2/43 (4.6%) 0/61 (0%) 17/38 (44.7%) 
Anorectal malformations 4/14 (28.6%) 0/14 (0%) 11/16 (68.8%) 
Ventricular septum defects 2/10 (20.0%) 0/10 (0%) 7/10 (70.0%) 
Sall4+/-Sall1+/-Sall4+/- Sall1+/-
Renal agenesis* 0/43 (0%) 2/61 (3.3%) 16/38 (42.1%)§ 
Exencephaly* 2/43 (4.6%) 0/61 (0%) 17/38 (44.7%) 
Anorectal malformations 4/14 (28.6%) 0/14 (0%) 11/16 (68.8%) 
Ventricular septum defects 2/10 (20.0%) 0/10 (0%) 7/10 (70.0%) 
*

Examined at E13.5-P0.

Examined at E17.5-18.5.

Two Sall1 heterozygotes had unilateral kidney agenesis.

§

Six out of 16 double heterozygotes had no kidneys bilaterally, and ten had unilateral kidney agenesis.

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