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Table 4.

Phenotypic exacerbation in Sall4/Sall1 double heterozygous mice

	Sall4+/-	Sall1+/-	Sall4+/- Sall1+/-
Renal agenesis^{^*}	0/43 (0%)	2/61 (3.3%)^‡	16/38 (42.1%)^§
Exencephaly^{^*}	2/43 (4.6%)	0/61 (0%)	17/38 (44.7%)
Anorectal malformations^†	4/14 (28.6%)	0/14 (0%)	11/16 (68.8%)
Ventricular septum defects^†	2/10 (20.0%)	0/10 (0%)	7/10 (70.0%)

	Sall4+/-	Sall1+/-	Sall4+/- Sall1+/-
Renal agenesis^{^*}	0/43 (0%)	2/61 (3.3%)^‡	16/38 (42.1%)^§
Exencephaly^{^*}	2/43 (4.6%)	0/61 (0%)	17/38 (44.7%)
Anorectal malformations^†	4/14 (28.6%)	0/14 (0%)	11/16 (68.8%)
Ventricular septum defects^†	2/10 (20.0%)	0/10 (0%)	7/10 (70.0%)

Examined at E13.5-P0.

Examined at E17.5-18.5.

Two Sall1 heterozygotes had unilateral kidney agenesis.

Six out of 16 double heterozygotes had no kidneys bilaterally, and ten had unilateral kidney agenesis.